PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Populus euphratica
HD-ZIP Family
Species TF ID Description
CCG032962.1HD-ZIP family protein
CCG023527.2HD-ZIP family protein
CCG000858.1HD-ZIP family protein
CCG020034.1HD-ZIP family protein
CCG022455.1HD-ZIP family protein
CCG022841.1HD-ZIP family protein
CCG004828.1HD-ZIP family protein
CCG006147.1HD-ZIP family protein
CCG030883.1HD-ZIP family protein
CCG002655.1HD-ZIP family protein
CCG024586.1HD-ZIP family protein
CCG029931.1HD-ZIP family protein
CCG023040.1HD-ZIP family protein
CCG011815.1HD-ZIP family protein
CCG010396.1HD-ZIP family protein
CCG003660.1HD-ZIP family protein
CCG010842.1HD-ZIP family protein
CCG027858.1HD-ZIP family protein
CCG032251.1HD-ZIP family protein
CCG023659.1HD-ZIP family protein
CCG018924.1HD-ZIP family protein
CCG023660.1HD-ZIP family protein
CCG027540.1HD-ZIP family protein
CCG011194.1HD-ZIP family protein
CCG026680.1HD-ZIP family protein
CCG027654.1HD-ZIP family protein
CCG007530.1HD-ZIP family protein
CCG023796.1HD-ZIP family protein
CCG000699.1HD-ZIP family protein
CCG003790.1HD-ZIP family protein
CCG006719.1HD-ZIP family protein
CCG029627.1HD-ZIP family protein
CCG032421.1HD-ZIP family protein
CCG028530.1HD-ZIP family protein
CCG022190.1HD-ZIP family protein
CCG010050.1HD-ZIP family protein
CCG012995.1HD-ZIP family protein
CCG029426.1HD-ZIP family protein
CCG002783.1HD-ZIP family protein
CCG032061.1HD-ZIP family protein
CCG016852.1HD-ZIP family protein
CCG003566.1HD-ZIP family protein
CCG008904.1HD-ZIP family protein
CCG019102.1HD-ZIP family protein
CCG010605.1HD-ZIP family protein
CCG002826.1HD-ZIP family protein
CCG009505.1HD-ZIP family protein
CCG005953.1HD-ZIP family protein
CCG025755.2HD-ZIP family protein
CCG008945.1HD-ZIP family protein
CCG003054.1HD-ZIP family protein
CCG024223.2HD-ZIP family protein
CCG001343.1HD-ZIP family protein
CCG033678.2HD-ZIP family protein
CCG003168.2HD-ZIP family protein
CCG007219.1HD-ZIP family protein
CCG024759.1HD-ZIP family protein
CCG028260.1HD-ZIP family protein
CCG014412.1HD-ZIP family protein
CCG019143.1HD-ZIP family protein
CCG004141.1HD-ZIP family protein
CCG028185.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401