PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Phoenix dactylifera
bHLH Family
Species TF ID Description
PDK_30s1001281g002bHLH family protein
PDK_30s1007061g002bHLH family protein
PDK_30s1008141g001bHLH family protein
PDK_30s1009141g004bHLH family protein
PDK_30s1012891g001bHLH family protein
PDK_30s1026291g001bHLH family protein
PDK_30s1030181g010bHLH family protein
PDK_30s1034021g002bHLH family protein
PDK_30s1038011g001bHLH family protein
PDK_30s1042771g006bHLH family protein
PDK_30s1050941g001bHLH family protein
PDK_30s1052321g004bHLH family protein
PDK_30s1060091g001bHLH family protein
PDK_30s1062821g001bHLH family protein
PDK_30s1065481g001bHLH family protein
PDK_30s1075261g004bHLH family protein
PDK_30s1077681g001bHLH family protein
PDK_30s1082161g001bHLH family protein
PDK_30s1085741g001bHLH family protein
PDK_30s1086881g001bHLH family protein
PDK_30s1089221g008bHLH family protein
PDK_30s1089541g005bHLH family protein
PDK_30s1089941g001bHLH family protein
PDK_30s1094891g003bHLH family protein
PDK_30s1097831g002bHLH family protein
PDK_30s1098031g002bHLH family protein
PDK_30s1103751g030bHLH family protein
PDK_30s1116821g001bHLH family protein
PDK_30s1122501g011bHLH family protein
PDK_30s1135241g002bHLH family protein
PDK_30s1139301g001bHLH family protein
PDK_30s1143761g001bHLH family protein
PDK_30s1166341g001bHLH family protein
PDK_30s1183851g002bHLH family protein
PDK_30s1190441g011bHLH family protein
PDK_30s1207141g005bHLH family protein
PDK_30s65509157g005bHLH family protein
PDK_30s65509157g006bHLH family protein
PDK_30s6550926g027bHLH family protein
PDK_30s6550926g038bHLH family protein
PDK_30s65509416g003bHLH family protein
PDK_30s656261g003bHLH family protein
PDK_30s657001g004bHLH family protein
PDK_30s664571g001bHLH family protein
PDK_30s664641g001bHLH family protein
PDK_30s668421g002bHLH family protein
PDK_30s668471g003bHLH family protein
PDK_30s670321g008bHLH family protein
PDK_30s671191g001bHLH family protein
PDK_30s672321g006bHLH family protein
PDK_30s680151g004bHLH family protein
PDK_30s680181g002bHLH family protein
PDK_30s682431g001bHLH family protein
PDK_30s684311g002bHLH family protein
PDK_30s691361g001bHLH family protein
PDK_30s693171g003bHLH family protein
PDK_30s701111g001bHLH family protein
PDK_30s703171g006bHLH family protein
PDK_30s704581g001bHLH family protein
PDK_30s704941g001bHLH family protein
PDK_30s710201g001bHLH family protein
PDK_30s711561g001bHLH family protein
PDK_30s715151g001bHLH family protein
PDK_30s717121g001bHLH family protein
PDK_30s718521g005bHLH family protein
PDK_30s728681g004bHLH family protein
PDK_30s730711g001bHLH family protein
PDK_30s731031g006bHLH family protein
PDK_30s732391g001bHLH family protein
PDK_30s733332g003bHLH family protein
PDK_30s737611g001bHLH family protein
PDK_30s738391g001bHLH family protein
PDK_30s747271g001bHLH family protein
PDK_30s751961g001bHLH family protein
PDK_30s756321g001bHLH family protein
PDK_30s758201g002bHLH family protein
PDK_30s760301g004bHLH family protein
PDK_30s761451g004bHLH family protein
PDK_30s763151g002bHLH family protein
PDK_30s765181g004bHLH family protein
PDK_30s766981g005bHLH family protein
PDK_30s770491g001bHLH family protein
PDK_30s770951g001bHLH family protein
PDK_30s774131g011bHLH family protein
PDK_30s779621g008bHLH family protein
PDK_30s783041g012bHLH family protein
PDK_30s790251g005bHLH family protein
PDK_30s792411g001bHLH family protein
PDK_30s804031g001bHLH family protein
PDK_30s813151g001bHLH family protein
PDK_30s819571g004bHLH family protein
PDK_30s837171g001bHLH family protein
PDK_30s840231g002bHLH family protein
PDK_30s841271g002bHLH family protein
PDK_30s846221g001bHLH family protein
PDK_30s849551g004bHLH family protein
PDK_30s854621g001bHLH family protein
PDK_30s864051g004bHLH family protein
PDK_30s867271g011bHLH family protein
PDK_30s868711g002bHLH family protein
PDK_30s873901g001bHLH family protein
PDK_30s873901g002bHLH family protein
PDK_30s891671g001bHLH family protein
PDK_30s909501g001bHLH family protein
PDK_30s909501g002bHLH family protein
PDK_30s910961g001bHLH family protein
PDK_30s918321g001bHLH family protein
PDK_30s919471g001bHLH family protein
PDK_30s920981g003bHLH family protein
PDK_30s925571g003bHLH family protein
PDK_30s935001g001bHLH family protein
PDK_30s936561g006bHLH family protein
PDK_30s939121g001bHLH family protein
PDK_30s940741g004bHLH family protein
PDK_30s942371g001bHLH family protein
PDK_30s953031g001bHLH family protein
PDK_30s953231g002bHLH family protein
PDK_30s959551g002bHLH family protein
PDK_30s963251g002bHLH family protein
PDK_30s969931g006bHLH family protein
PDK_30s972611g004bHLH family protein
PDK_30s975801g005bHLH family protein
PDK_30s977061g001bHLH family protein
PDK_30s987991g011bHLH family protein
PDK_30s989101g001bHLH family protein
PDK_30s992571g002bHLH family protein
PDK_30s993871g006bHLH family protein
PDK_30s996831g001bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250