PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Pyrus bretschneideri
HD-ZIP Family
Species TF ID Description
Pbr039116.1HD-ZIP family protein
Pbr017942.1HD-ZIP family protein
Pbr008217.1HD-ZIP family protein
Pbr006330.2HD-ZIP family protein
Pbr034174.1HD-ZIP family protein
Pbr011488.1HD-ZIP family protein
Pbr001571.1HD-ZIP family protein
Pbr040636.1HD-ZIP family protein
Pbr041852.1HD-ZIP family protein
Pbr036101.1HD-ZIP family protein
Pbr035756.1HD-ZIP family protein
Pbr029399.1HD-ZIP family protein
Pbr035813.1HD-ZIP family protein
Pbr039143.1HD-ZIP family protein
Pbr004979.1HD-ZIP family protein
Pbr029884.1HD-ZIP family protein
Pbr023774.1HD-ZIP family protein
Pbr024282.1HD-ZIP family protein
Pbr024283.1HD-ZIP family protein
Pbr040074.1HD-ZIP family protein
Pbr019804.1HD-ZIP family protein
Pbr013533.1HD-ZIP family protein
Pbr029255.1HD-ZIP family protein
Pbr013425.1HD-ZIP family protein
Pbr013429.1HD-ZIP family protein
Pbr014724.1HD-ZIP family protein
Pbr028712.1HD-ZIP family protein
Pbr030778.1HD-ZIP family protein
Pbr033717.1HD-ZIP family protein
Pbr025453.1HD-ZIP family protein
Pbr032408.1HD-ZIP family protein
Pbr018403.1HD-ZIP family protein
Pbr007829.1HD-ZIP family protein
Pbr030226.1HD-ZIP family protein
Pbr038266.1HD-ZIP family protein
Pbr017259.1HD-ZIP family protein
Pbr028628.1HD-ZIP family protein
Pbr019166.1HD-ZIP family protein
Pbr018089.3HD-ZIP family protein
Pbr034468.1HD-ZIP family protein
Pbr000180.1HD-ZIP family protein
Pbr031858.8HD-ZIP family protein
Pbr032434.9HD-ZIP family protein
Pbr028309.1HD-ZIP family protein
Pbr013948.1HD-ZIP family protein
Pbr008785.1HD-ZIP family protein
Pbr037485.1HD-ZIP family protein
Pbr042103.1HD-ZIP family protein
Pbr019133.1HD-ZIP family protein
Pbr016310.4HD-ZIP family protein
Pbr008410.2HD-ZIP family protein
Pbr008477.1HD-ZIP family protein
Pbr005447.1HD-ZIP family protein
Pbr012633.1HD-ZIP family protein
Pbr008476.1HD-ZIP family protein
Pbr012632.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401