PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Petunia axillaris
MIKC_MADS Family
Species TF ID Description
Peaxi162Scf00013g00725.1MIKC_MADS family protein
Peaxi162Scf00016g03458.1MIKC_MADS family protein
Peaxi162Scf00017g03246.1MIKC_MADS family protein
Peaxi162Scf00017g03265.1MIKC_MADS family protein
Peaxi162Scf00020g02337.1MIKC_MADS family protein
Peaxi162Scf00020g02338.1MIKC_MADS family protein
Peaxi162Scf00021g00015.1MIKC_MADS family protein
Peaxi162Scf00021g00117.1MIKC_MADS family protein
Peaxi162Scf00022g00098.1MIKC_MADS family protein
Peaxi162Scf00023g02913.1MIKC_MADS family protein
Peaxi162Scf00066g00133.1MIKC_MADS family protein
Peaxi162Scf00083g01812.1MIKC_MADS family protein
Peaxi162Scf00089g00129.1MIKC_MADS family protein
Peaxi162Scf00128g01417.1MIKC_MADS family protein
Peaxi162Scf00130g00423.1MIKC_MADS family protein
Peaxi162Scf00154g00516.1MIKC_MADS family protein
Peaxi162Scf00175g00918.1MIKC_MADS family protein
Peaxi162Scf00191g00114.1MIKC_MADS family protein
Peaxi162Scf00269g01618.1MIKC_MADS family protein
Peaxi162Scf00299g00717.1MIKC_MADS family protein
Peaxi162Scf00365g00212.1MIKC_MADS family protein
Peaxi162Scf00454g00519.1MIKC_MADS family protein
Peaxi162Scf00481g00721.1MIKC_MADS family protein
Peaxi162Scf00591g00074.1MIKC_MADS family protein
Peaxi162Scf00620g00624.1MIKC_MADS family protein
Peaxi162Scf00688g00218.1MIKC_MADS family protein
Peaxi162Scf00688g00335.1MIKC_MADS family protein
Peaxi162Scf00703g00011.1MIKC_MADS family protein
Peaxi162Scf00848g00319.1MIKC_MADS family protein
Peaxi162Scf00922g00026.1MIKC_MADS family protein
Peaxi162Scf01084g00119.1MIKC_MADS family protein
Peaxi162Scf01108g00332.1MIKC_MADS family protein
Peaxi162Scf01294g00240.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513