PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Picea abies
HD-ZIP Family
Species TF ID Description
MA_19453g0040HD-ZIP family protein
MA_169305g0010HD-ZIP family protein
MA_238039g0010HD-ZIP family protein
MA_13587g0010HD-ZIP family protein
MA_3688g0010HD-ZIP family protein
MA_60543g0010HD-ZIP family protein
MA_57689g0010HD-ZIP family protein
MA_60457g0010HD-ZIP family protein
MA_12174g0010HD-ZIP family protein
MA_130615g0020HD-ZIP family protein
MA_10434389g0010HD-ZIP family protein
MA_9241385g0010HD-ZIP family protein
MA_12053g0010HD-ZIP family protein
MA_126021g0010HD-ZIP family protein
MA_132936g0010HD-ZIP family protein
MA_194299g0010HD-ZIP family protein
MA_3951g0010HD-ZIP family protein
MA_12866g0010HD-ZIP family protein
MA_128g0010HD-ZIP family protein
MA_10428916g0010HD-ZIP family protein
MA_21460g0010HD-ZIP family protein
MA_78381g0010HD-ZIP family protein
MA_441783g0010HD-ZIP family protein
MA_93471g0010HD-ZIP family protein
MA_122121g0010HD-ZIP family protein
MA_38472g0010HD-ZIP family protein
MA_305431g0010HD-ZIP family protein
MA_10427484g0010HD-ZIP family protein
MA_19520g0020HD-ZIP family protein
MA_112057g0010HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401