PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Ocimum tenuiflorum
bHLH Family
Species TF ID Description
Ote100002730131bHLH family protein
Ote100003020021bHLH family protein
Ote100003020041bHLH family protein
Ote100003900031bHLH family protein
Ote100008900001bHLH family protein
Ote100011930021bHLH family protein
Ote100018280011bHLH family protein
Ote100021640121bHLH family protein
Ote100022230071bHLH family protein
Ote100023860031bHLH family protein
Ote100023940131bHLH family protein
Ote100026100061bHLH family protein
Ote100028950011bHLH family protein
Ote100028950021bHLH family protein
Ote100029421111bHLH family protein
Ote100030740011bHLH family protein
Ote100037740011bHLH family protein
Ote100050320051bHLH family protein
Ote100050780031bHLH family protein
Ote100058770071bHLH family protein
Ote100058770121bHLH family protein
Ote100061790101bHLH family protein
Ote100061800021bHLH family protein
Ote100065340071bHLH family protein
Ote100065340111bHLH family protein
Ote100066420021bHLH family protein
Ote100068500161bHLH family protein
Ote100071510191bHLH family protein
Ote100072620171bHLH family protein
Ote100073310021bHLH family protein
Ote100073880031bHLH family protein
Ote100073880032bHLH family protein
Ote100074990011bHLH family protein
Ote100074990012bHLH family protein
Ote100077310101bHLH family protein
Ote100079200021bHLH family protein
Ote100079950001bHLH family protein
Ote100082030041bHLH family protein
Ote100084400041bHLH family protein
Ote100086320041bHLH family protein
Ote100087930001bHLH family protein
Ote100091510011bHLH family protein
Ote100092570011bHLH family protein
Ote100093840041bHLH family protein
Ote100093910031bHLH family protein
Ote100094140091bHLH family protein
Ote100094140191bHLH family protein
Ote100094960051bHLH family protein
Ote100095100081bHLH family protein
Ote100095340071bHLH family protein
Ote100095340191bHLH family protein
Ote100098130121bHLH family protein
Ote100098470011bHLH family protein
Ote100098800091bHLH family protein
Ote100106800021bHLH family protein
Ote100109180071bHLH family protein
Ote100109180262bHLH family protein
Ote100111190071bHLH family protein
Ote100111190081bHLH family protein
Ote100111190082bHLH family protein
Ote100112080011bHLH family protein
Ote100118870131bHLH family protein
Ote100120410021bHLH family protein
Ote100120410061bHLH family protein
Ote100120600101bHLH family protein
Ote100122340001bHLH family protein
Ote100124420051bHLH family protein
Ote100124650011bHLH family protein
Ote100127090141bHLH family protein
Ote100129680091bHLH family protein
Ote100129680141bHLH family protein
Ote100129990021bHLH family protein
Ote100131300001bHLH family protein
Ote100131300011bHLH family protein
Ote100132900001bHLH family protein
Ote100134140101bHLH family protein
Ote100140760001bHLH family protein
Ote100143370031bHLH family protein
Ote100147490081bHLH family protein
Ote100149350041bHLH family protein
Ote100149350111bHLH family protein
Ote100150500011bHLH family protein
Ote100152750061bHLH family protein
Ote100153320031bHLH family protein
Ote100154470011bHLH family protein
Ote100156430051bHLH family protein
Ote100156470051bHLH family protein
Ote100164110031bHLH family protein
Ote100164500051bHLH family protein
Ote100164580021bHLH family protein
Ote100165210021bHLH family protein
Ote100168040081bHLH family protein
Ote100168600061bHLH family protein
Ote100168600071bHLH family protein
Ote100172060001bHLH family protein
Ote100175130071bHLH family protein
Ote100175130072bHLH family protein
Ote100175210041bHLH family protein
Ote100184580021bHLH family protein
Ote100187700041bHLH family protein
Ote100187700071bHLH family protein
Ote100190040111bHLH family protein
Ote100191900061bHLH family protein
Ote100192690001bHLH family protein
Ote100193460031bHLH family protein
Ote100194770131bHLH family protein
Ote100199080091bHLH family protein
Ote100202600021bHLH family protein
Ote100205000051bHLH family protein
Ote100211160141bHLH family protein
Ote100214790021bHLH family protein
Ote100218550061bHLH family protein
Ote100218900011bHLH family protein
Ote100220670011bHLH family protein
Ote100221470051bHLH family protein
Ote100221470052bHLH family protein
Ote100222360031bHLH family protein
Ote100222520021bHLH family protein
Ote100224720081bHLH family protein
Ote100224730021bHLH family protein
Ote100224730031bHLH family protein
Ote100226270011bHLH family protein
Ote100227130021bHLH family protein
Ote100227420081bHLH family protein
Ote100227480071bHLH family protein
Ote100227500191bHLH family protein
Ote100230010081bHLH family protein
Ote100237790041bHLH family protein
Ote100238850151bHLH family protein
Ote100238850152bHLH family protein
Ote100239600001bHLH family protein
Ote100240600091bHLH family protein
Ote100243370041bHLH family protein
Ote100243370051bHLH family protein
Ote100243370211bHLH family protein
Ote100247590261bHLH family protein
Ote100247590262bHLH family protein
Ote100249890081bHLH family protein
Ote100250060031bHLH family protein
Ote100250190031bHLH family protein
Ote100252220031bHLH family protein
Ote100254190111bHLH family protein
Ote100256130001bHLH family protein
Ote100259380011bHLH family protein
Ote100261710021bHLH family protein
Ote100261710051bHLH family protein
Ote100262240031bHLH family protein
Ote100262240071bHLH family protein
Ote100263660011bHLH family protein
Ote100266660081bHLH family protein
Ote100267040011bHLH family protein
Ote100267040051bHLH family protein
Ote100268410001bHLH family protein
Ote100268410021bHLH family protein
Ote100270430041bHLH family protein
Ote100275570031bHLH family protein
Ote100275780021bHLH family protein
Ote100275780041bHLH family protein
Ote100278360041bHLH family protein
Ote234846540001bHLH family protein
Ote237540160011bHLH family protein
Ote237759810011bHLH family protein
Ote237894910041bHLH family protein
Ote237894910042bHLH family protein
Ote237918370011bHLH family protein
Ote237954130021bHLH family protein
Ote238045830041bHLH family protein
Ote238055620031bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250