PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Ocimum tenuiflorum
HD-ZIP Family
Species TF ID Description
Ote100176570111HD-ZIP family protein
Ote100199080181HD-ZIP family protein
Ote100009180061HD-ZIP family protein
Ote100085400061HD-ZIP family protein
Ote100088950061HD-ZIP family protein
Ote100267110011HD-ZIP family protein
Ote100064780151HD-ZIP family protein
Ote100200940031HD-ZIP family protein
Ote100019740001HD-ZIP family protein
Ote100175460201HD-ZIP family protein
Ote100150770061HD-ZIP family protein
Ote100113030061HD-ZIP family protein
Ote100165240031HD-ZIP family protein
Ote100263870011HD-ZIP family protein
Ote100048360111HD-ZIP family protein
Ote100246550041HD-ZIP family protein
Ote100019310001HD-ZIP family protein
Ote100124950071HD-ZIP family protein
Ote100080620021HD-ZIP family protein
Ote100237740061HD-ZIP family protein
Ote100000360031HD-ZIP family protein
Ote100060960001HD-ZIP family protein
Ote100075920071HD-ZIP family protein
Ote100209940031HD-ZIP family protein
Ote100014550041HD-ZIP family protein
Ote100135270001HD-ZIP family protein
Ote100253700041HD-ZIP family protein
Ote100184950081HD-ZIP family protein
Ote100204610001HD-ZIP family protein
Ote100084360001HD-ZIP family protein
Ote100268650011HD-ZIP family protein
Ote100065610001HD-ZIP family protein
Ote100104420031HD-ZIP family protein
Ote100224380001HD-ZIP family protein
Ote100224380011HD-ZIP family protein
Ote100087710001HD-ZIP family protein
Ote100040361011HD-ZIP family protein
Ote100272800011HD-ZIP family protein
Ote100078770001HD-ZIP family protein
Ote100055140101HD-ZIP family protein
Ote100258520041HD-ZIP family protein
Ote100079250021HD-ZIP family protein
Ote237979190031HD-ZIP family protein
Ote237979190021HD-ZIP family protein
Ote100228980001HD-ZIP family protein
Ote100246860151HD-ZIP family protein
Ote100093940021HD-ZIP family protein
Ote100208680011HD-ZIP family protein
Ote100265120171HD-ZIP family protein
Ote100197660071HD-ZIP family protein
Ote100174200072HD-ZIP family protein
Ote100174200071HD-ZIP family protein
Ote100192440101HD-ZIP family protein
Ote100254230031HD-ZIP family protein
Ote100228250231HD-ZIP family protein
Ote100227770081HD-ZIP family protein
Ote100149170011HD-ZIP family protein
Ote100036140061HD-ZIP family protein
Ote100028870051HD-ZIP family protein
Ote100047670021HD-ZIP family protein
Ote100200850061HD-ZIP family protein
Ote100180970021HD-ZIP family protein
Ote100180970011HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401