PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza sativa subsp. japonica
HD-ZIP Family
Species TF ID Description
LOC_Os08g37580.1HD-ZIP family protein
LOC_Os02g49700.2HD-ZIP family protein
LOC_Os02g49700.3HD-ZIP family protein
LOC_Os08g32080.1HD-ZIP family protein
LOC_Os08g32085.1HD-ZIP family protein
LOC_Os02g49700.1HD-ZIP family protein
LOC_Os09g29460.1HD-ZIP family protein
LOC_Os03g07450.1HD-ZIP family protein
LOC_Os04g46350.1HD-ZIP family protein
LOC_Os08g36220.1HD-ZIP family protein
LOC_Os03g08960.1HD-ZIP family protein
LOC_Os10g26500.1HD-ZIP family protein
LOC_Os09g27450.1HD-ZIP family protein
LOC_Os10g41230.1HD-ZIP family protein
LOC_Os10g01470.1HD-ZIP family protein
LOC_Os02g35770.1HD-ZIP family protein
LOC_Os10g23090.2HD-ZIP family protein
LOC_Os10g23090.1HD-ZIP family protein
LOC_Os04g45810.1HD-ZIP family protein
LOC_Os06g04850.1HD-ZIP family protein
LOC_Os03g12860.1HD-ZIP family protein
LOC_Os06g04870.1HD-ZIP family protein
LOC_Os02g43330.1HD-ZIP family protein
LOC_Os09g35910.1HD-ZIP family protein
LOC_Os09g21180.1HD-ZIP family protein
LOC_Os01g45570.1HD-ZIP family protein
LOC_Os06g48290.1HD-ZIP family protein
LOC_Os07g39320.1HD-ZIP family protein
LOC_Os02g05640.1HD-ZIP family protein
LOC_Os03g10210.1HD-ZIP family protein
LOC_Os08g08820.1HD-ZIP family protein
LOC_Os08g08820.2HD-ZIP family protein
LOC_Os04g53540.4HD-ZIP family protein
LOC_Os04g53540.1HD-ZIP family protein
LOC_Os04g53540.2HD-ZIP family protein
LOC_Os04g53540.3HD-ZIP family protein
LOC_Os08g04190.1HD-ZIP family protein
LOC_Os02g45250.1HD-ZIP family protein
LOC_Os09g35760.1HD-ZIP family protein
LOC_Os09g35760.2HD-ZIP family protein
LOC_Os03g43930.1HD-ZIP family protein
LOC_Os03g43930.2HD-ZIP family protein
LOC_Os01g55549.1HD-ZIP family protein
LOC_Os12g41860.1HD-ZIP family protein
LOC_Os03g01890.2HD-ZIP family protein
LOC_Os03g01890.1HD-ZIP family protein
LOC_Os04g48070.2HD-ZIP family protein
LOC_Os10g33960.4HD-ZIP family protein
LOC_Os10g33960.3HD-ZIP family protein
LOC_Os10g33960.1HD-ZIP family protein
LOC_Os10g33960.2HD-ZIP family protein
LOC_Os04g48070.3HD-ZIP family protein
LOC_Os04g48070.1HD-ZIP family protein
LOC_Os10g42490.1HD-ZIP family protein
LOC_Os10g42490.2HD-ZIP family protein
LOC_Os06g10600.1HD-ZIP family protein
LOC_Os08g19590.1HD-ZIP family protein
LOC_Os08g19590.2HD-ZIP family protein
LOC_Os08g19590.3HD-ZIP family protein
LOC_Os01g57890.2HD-ZIP family protein
LOC_Os01g57890.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401