PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza sativa subsp. indica
bHLH Family
Species TF ID Description
BGIOSGA000097-PAbHLH family protein
BGIOSGA000206-PAbHLH family protein
BGIOSGA000262-PAbHLH family protein
BGIOSGA000686-PAbHLH family protein
BGIOSGA000939-PAbHLH family protein
BGIOSGA001324-PAbHLH family protein
BGIOSGA001389-PAbHLH family protein
BGIOSGA001523-PAbHLH family protein
BGIOSGA001526-PAbHLH family protein
BGIOSGA001870-PAbHLH family protein
BGIOSGA002533-PAbHLH family protein
BGIOSGA002535-PAbHLH family protein
BGIOSGA002600-PAbHLH family protein
BGIOSGA002618-PAbHLH family protein
BGIOSGA002619-PAbHLH family protein
BGIOSGA002833-PAbHLH family protein
BGIOSGA002940-PAbHLH family protein
BGIOSGA002941-PAbHLH family protein
BGIOSGA002943-PAbHLH family protein
BGIOSGA003013-PAbHLH family protein
BGIOSGA003814-PAbHLH family protein
BGIOSGA003819-PAbHLH family protein
BGIOSGA003821-PAbHLH family protein
BGIOSGA004292-PAbHLH family protein
BGIOSGA004540-PAbHLH family protein
BGIOSGA004544-PAbHLH family protein
BGIOSGA004736-PAbHLH family protein
BGIOSGA004859-PAbHLH family protein
BGIOSGA004992-PAbHLH family protein
BGIOSGA005178-PAbHLH family protein
BGIOSGA005408-PAbHLH family protein
BGIOSGA005582-PAbHLH family protein
BGIOSGA005623-PAbHLH family protein
BGIOSGA005697-PAbHLH family protein
BGIOSGA005771-PAbHLH family protein
BGIOSGA006236-PAbHLH family protein
BGIOSGA006748-PAbHLH family protein
BGIOSGA006833-PAbHLH family protein
BGIOSGA006856-PAbHLH family protein
BGIOSGA007229-PAbHLH family protein
BGIOSGA007247-PAbHLH family protein
BGIOSGA008112-PAbHLH family protein
BGIOSGA008398-PAbHLH family protein
BGIOSGA008400-PAbHLH family protein
BGIOSGA008576-PAbHLH family protein
BGIOSGA008846-PAbHLH family protein
BGIOSGA008903-PAbHLH family protein
BGIOSGA009202-PAbHLH family protein
BGIOSGA009622-PAbHLH family protein
BGIOSGA010080-PAbHLH family protein
BGIOSGA010239-PAbHLH family protein
BGIOSGA010315-PAbHLH family protein
BGIOSGA010604-PAbHLH family protein
BGIOSGA010986-PAbHLH family protein
BGIOSGA010988-PAbHLH family protein
BGIOSGA011172-PAbHLH family protein
BGIOSGA011179-PAbHLH family protein
BGIOSGA011251-PAbHLH family protein
BGIOSGA011363-PAbHLH family protein
BGIOSGA011499-PAbHLH family protein
BGIOSGA011741-PAbHLH family protein
BGIOSGA011954-PAbHLH family protein
BGIOSGA012015-PAbHLH family protein
BGIOSGA012265-PAbHLH family protein
BGIOSGA012750-PAbHLH family protein
BGIOSGA013197-PAbHLH family protein
BGIOSGA013293-PAbHLH family protein
BGIOSGA013493-PAbHLH family protein
BGIOSGA013533-PAbHLH family protein
BGIOSGA013600-PAbHLH family protein
BGIOSGA013618-PAbHLH family protein
BGIOSGA013672-PAbHLH family protein
BGIOSGA013729-PAbHLH family protein
BGIOSGA013800-PAbHLH family protein
BGIOSGA014246-PAbHLH family protein
BGIOSGA014424-PAbHLH family protein
BGIOSGA014565-PAbHLH family protein
BGIOSGA014566-PAbHLH family protein
BGIOSGA014567-PAbHLH family protein
BGIOSGA015290-PAbHLH family protein
BGIOSGA015389-PAbHLH family protein
BGIOSGA015472-PAbHLH family protein
BGIOSGA015604-PAbHLH family protein
BGIOSGA016251-PAbHLH family protein
BGIOSGA016426-PAbHLH family protein
BGIOSGA016427-PAbHLH family protein
BGIOSGA016651-PAbHLH family protein
BGIOSGA017025-PAbHLH family protein
BGIOSGA017139-PAbHLH family protein
BGIOSGA017200-PAbHLH family protein
BGIOSGA017471-PAbHLH family protein
BGIOSGA018982-PAbHLH family protein
BGIOSGA019157-PAbHLH family protein
BGIOSGA019218-PAbHLH family protein
BGIOSGA019238-PAbHLH family protein
BGIOSGA020126-PAbHLH family protein
BGIOSGA020128-PAbHLH family protein
BGIOSGA020285-PAbHLH family protein
BGIOSGA020491-PAbHLH family protein
BGIOSGA020891-PAbHLH family protein
BGIOSGA021743-PAbHLH family protein
BGIOSGA021777-PAbHLH family protein
BGIOSGA022375-PAbHLH family protein
BGIOSGA022533-PAbHLH family protein
BGIOSGA022576-PAbHLH family protein
BGIOSGA022687-PAbHLH family protein
BGIOSGA022967-PAbHLH family protein
BGIOSGA023024-PAbHLH family protein
BGIOSGA023114-PAbHLH family protein
BGIOSGA023624-PAbHLH family protein
BGIOSGA023869-PAbHLH family protein
BGIOSGA023988-PAbHLH family protein
BGIOSGA024146-PAbHLH family protein
BGIOSGA024674-PAbHLH family protein
BGIOSGA025137-PAbHLH family protein
BGIOSGA025266-PAbHLH family protein
BGIOSGA025388-PAbHLH family protein
BGIOSGA025912-PAbHLH family protein
BGIOSGA026551-PAbHLH family protein
BGIOSGA026577-PAbHLH family protein
BGIOSGA026775-PAbHLH family protein
BGIOSGA026779-PAbHLH family protein
BGIOSGA026828-PAbHLH family protein
BGIOSGA026937-PAbHLH family protein
BGIOSGA027551-PAbHLH family protein
BGIOSGA027691-PAbHLH family protein
BGIOSGA027780-PAbHLH family protein
BGIOSGA028855-PAbHLH family protein
BGIOSGA028884-PAbHLH family protein
BGIOSGA028888-PAbHLH family protein
BGIOSGA028963-PAbHLH family protein
BGIOSGA029027-PAbHLH family protein
BGIOSGA029426-PAbHLH family protein
BGIOSGA029460-PAbHLH family protein
BGIOSGA029497-PAbHLH family protein
BGIOSGA029658-PAbHLH family protein
BGIOSGA029759-PAbHLH family protein
BGIOSGA029777-PAbHLH family protein
BGIOSGA030896-PAbHLH family protein
BGIOSGA030928-PAbHLH family protein
BGIOSGA030936-PAbHLH family protein
BGIOSGA030954-PAbHLH family protein
BGIOSGA030958-PAbHLH family protein
BGIOSGA031008-PAbHLH family protein
BGIOSGA031426-PAbHLH family protein
BGIOSGA031474-PAbHLH family protein
BGIOSGA031957-PAbHLH family protein
BGIOSGA032415-PAbHLH family protein
BGIOSGA032814-PAbHLH family protein
BGIOSGA032878-PAbHLH family protein
BGIOSGA033493-PAbHLH family protein
BGIOSGA033733-PAbHLH family protein
BGIOSGA033734-PAbHLH family protein
BGIOSGA033976-PAbHLH family protein
BGIOSGA035358-PAbHLH family protein
BGIOSGA035534-PAbHLH family protein
BGIOSGA035596-PAbHLH family protein
BGIOSGA035894-PAbHLH family protein
BGIOSGA035917-PAbHLH family protein
BGIOSGA037431-PAbHLH family protein
BGIOSGA037460-PAbHLH family protein
BGIOSGA037731-PAbHLH family protein
BGIOSGA037732-PAbHLH family protein
BGIOSGA037733-PAbHLH family protein
BGIOSGA037734-PAbHLH family protein
BGIOSGA037772-PAbHLH family protein
BGIOSGA037775-PAbHLH family protein
BGIOSGA037855-PAbHLH family protein
BGIOSGA040642-PAbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250