PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza rufipogon
MIKC_MADS Family
Species TF ID Description
ORUFI01G07080.1MIKC_MADS family protein
ORUFI01G07080.2MIKC_MADS family protein
ORUFI01G07080.3MIKC_MADS family protein
ORUFI01G32600.1MIKC_MADS family protein
ORUFI01G43090.1MIKC_MADS family protein
ORUFI01G43090.2MIKC_MADS family protein
ORUFI02G00390.1MIKC_MADS family protein
ORUFI02G00390.2MIKC_MADS family protein
ORUFI02G05500.1MIKC_MADS family protein
ORUFI02G05500.2MIKC_MADS family protein
ORUFI02G22950.1MIKC_MADS family protein
ORUFI02G22950.2MIKC_MADS family protein
ORUFI02G29550.1MIKC_MADS family protein
ORUFI02G32980.1MIKC_MADS family protein
ORUFI02G32980.2MIKC_MADS family protein
ORUFI02G32980.3MIKC_MADS family protein
ORUFI02G34940.1MIKC_MADS family protein
ORUFI03G01510.2MIKC_MADS family protein
ORUFI03G06210.1MIKC_MADS family protein
ORUFI03G06210.2MIKC_MADS family protein
ORUFI03G08410.1MIKC_MADS family protein
ORUFI03G35930.1MIKC_MADS family protein
ORUFI03G35930.2MIKC_MADS family protein
ORUFI03G35940.1MIKC_MADS family protein
ORUFI04G08040.1MIKC_MADS family protein
ORUFI04G15060.1MIKC_MADS family protein
ORUFI04G16410.1MIKC_MADS family protein
ORUFI04G24470.1MIKC_MADS family protein
ORUFI04G24470.2MIKC_MADS family protein
ORUFI04G26810.1MIKC_MADS family protein
ORUFI05G05970.1MIKC_MADS family protein
ORUFI05G07090.1MIKC_MADS family protein
ORUFI05G07100.1MIKC_MADS family protein
ORUFI05G07100.2MIKC_MADS family protein
ORUFI05G18270.1MIKC_MADS family protein
ORUFI06G00550.1MIKC_MADS family protein
ORUFI06G04180.1MIKC_MADS family protein
ORUFI06G14980.1MIKC_MADS family protein
ORUFI06G25880.1MIKC_MADS family protein
ORUFI06G29170.1MIKC_MADS family protein
ORUFI07G00610.1MIKC_MADS family protein
ORUFI07G00610.2MIKC_MADS family protein
ORUFI07G22480.1MIKC_MADS family protein
ORUFI07G22480.2MIKC_MADS family protein
ORUFI07G22480.3MIKC_MADS family protein
ORUFI08G00950.1MIKC_MADS family protein
ORUFI08G24040.1MIKC_MADS family protein
ORUFI08G24040.2MIKC_MADS family protein
ORUFI08G24040.3MIKC_MADS family protein
ORUFI08G24040.4MIKC_MADS family protein
ORUFI08G24040.5MIKC_MADS family protein
ORUFI08G24040.6MIKC_MADS family protein
ORUFI08G24040.7MIKC_MADS family protein
ORUFI09G17010.1MIKC_MADS family protein
ORUFI10G17990.1MIKC_MADS family protein
ORUFI10G17990.2MIKC_MADS family protein
ORUFI10G17990.3MIKC_MADS family protein
ORUFI12G06790.1MIKC_MADS family protein
ORUFI12G06810.1MIKC_MADS family protein
ORUFI12G06810.2MIKC_MADS family protein
ORUFI12G06810.3MIKC_MADS family protein
ORUFI12G06810.4MIKC_MADS family protein
ORUFI12G06810.5MIKC_MADS family protein
ORUFI12G14120.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513