PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza meridionalis
bHLH Family
Species TF ID Description
OMERI01G00060.1bHLH family protein
OMERI01G00100.1bHLH family protein
OMERI01G00290.1bHLH family protein
OMERI01G03850.1bHLH family protein
OMERI01G06280.1bHLH family protein
OMERI01G06290.1bHLH family protein
OMERI01G06300.1bHLH family protein
OMERI01G06300.2bHLH family protein
OMERI01G06310.1bHLH family protein
OMERI01G07330.1bHLH family protein
OMERI01G07330.2bHLH family protein
OMERI01G08610.1bHLH family protein
OMERI01G16690.1bHLH family protein
OMERI01G18460.1bHLH family protein
OMERI01G18730.1bHLH family protein
OMERI01G18770.1bHLH family protein
OMERI01G18860.1bHLH family protein
OMERI01G29650.1bHLH family protein
OMERI01G30260.1bHLH family protein
OMERI01G33130.1bHLH family protein
OMERI01G35270.1bHLH family protein
OMERI01G35270.2bHLH family protein
OMERI01G35270.3bHLH family protein
OMERI01G35270.4bHLH family protein
OMERI01G37660.1bHLH family protein
OMERI01G37660.2bHLH family protein
OMERI01G38640.1bHLH family protein
OMERI01G39590.1bHLH family protein
OMERI01G40940.1bHLH family protein
OMERI02G00630.1bHLH family protein
OMERI02G00890.1bHLH family protein
OMERI02G00890.3bHLH family protein
OMERI02G00890.4bHLH family protein
OMERI02G01640.1bHLH family protein
OMERI02G01640.2bHLH family protein
OMERI02G10300.1bHLH family protein
OMERI02G10300.2bHLH family protein
OMERI02G10940.1bHLH family protein
OMERI02G11850.1bHLH family protein
OMERI02G20700.1bHLH family protein
OMERI02G22740.1bHLH family protein
OMERI02G28340.1bHLH family protein
OMERI02G28660.1bHLH family protein
OMERI02G29850.1bHLH family protein
OMERI02G29850.2bHLH family protein
OMERI02G31120.1bHLH family protein
OMERI02G31750.1bHLH family protein
OMERI02G33790.1bHLH family protein
OMERI02G34410.1bHLH family protein
OMERI03G01350.1bHLH family protein
OMERI03G01680.1bHLH family protein
OMERI03G02800.1bHLH family protein
OMERI03G02800.2bHLH family protein
OMERI03G04020.1bHLH family protein
OMERI03G04040.1bHLH family protein
OMERI03G04040.2bHLH family protein
OMERI03G04040.3bHLH family protein
OMERI03G05000.2bHLH family protein
OMERI03G05020.1bHLH family protein
OMERI03G06350.1bHLH family protein
OMERI03G07360.1bHLH family protein
OMERI03G08710.1bHLH family protein
OMERI03G08820.1bHLH family protein
OMERI03G10610.1bHLH family protein
OMERI03G11830.1bHLH family protein
OMERI03G11830.2bHLH family protein
OMERI03G11830.3bHLH family protein
OMERI03G17430.2bHLH family protein
OMERI03G17460.1bHLH family protein
OMERI03G18290.1bHLH family protein
OMERI03G23570.1bHLH family protein
OMERI03G25360.1bHLH family protein
OMERI03G29350.1bHLH family protein
OMERI03G29530.1bHLH family protein
OMERI03G31010.1bHLH family protein
OMERI03G31980.1bHLH family protein
OMERI03G32400.1bHLH family protein
OMERI03G33580.1bHLH family protein
OMERI03G34570.2bHLH family protein
OMERI03G34570.3bHLH family protein
OMERI03G34570.4bHLH family protein
OMERI03G35020.1bHLH family protein
OMERI03G35360.1bHLH family protein
OMERI04G07880.1bHLH family protein
OMERI04G11480.1bHLH family protein
OMERI04G14260.1bHLH family protein
OMERI04G14260.2bHLH family protein
OMERI04G14260.3bHLH family protein
OMERI04G14260.4bHLH family protein
OMERI04G17790.1bHLH family protein
OMERI04G17810.1bHLH family protein
OMERI04G17820.1bHLH family protein
OMERI04G19830.1bHLH family protein
OMERI04G19830.2bHLH family protein
OMERI04G21140.1bHLH family protein
OMERI04G21930.1bHLH family protein
OMERI04G22430.1bHLH family protein
OMERI05G02570.1bHLH family protein
OMERI05G02570.2bHLH family protein
OMERI05G02570.3bHLH family protein
OMERI05G02570.4bHLH family protein
OMERI05G03980.1bHLH family protein
OMERI05G04410.1bHLH family protein
OMERI05G07470.1bHLH family protein
OMERI05G15760.1bHLH family protein
OMERI05G21560.1bHLH family protein
OMERI05G23490.1bHLH family protein
OMERI06G05090.1bHLH family protein
OMERI06G05430.1bHLH family protein
OMERI06G07190.1bHLH family protein
OMERI06G08170.1bHLH family protein
OMERI06G09660.1bHLH family protein
OMERI06G12470.1bHLH family protein
OMERI06G12470.2bHLH family protein
OMERI06G13890.1bHLH family protein
OMERI06G16990.1bHLH family protein
OMERI06G17780.1bHLH family protein
OMERI06G19340.1bHLH family protein
OMERI06G21500.1bHLH family protein
OMERI06G24090.1bHLH family protein
OMERI06G27810.1bHLH family protein
OMERI07G01290.1bHLH family protein
OMERI07G01290.2bHLH family protein
OMERI07G01290.3bHLH family protein
OMERI07G01290.4bHLH family protein
OMERI07G04150.1bHLH family protein
OMERI07G04600.1bHLH family protein
OMERI07G05880.1bHLH family protein
OMERI07G14510.1bHLH family protein
OMERI07G17220.1bHLH family protein
OMERI07G19420.1bHLH family protein
OMERI07G19420.2bHLH family protein
OMERI07G19420.3bHLH family protein
OMERI07G19420.4bHLH family protein
OMERI08G00980.1bHLH family protein
OMERI08G04810.1bHLH family protein
OMERI08G04810.2bHLH family protein
OMERI08G04810.3bHLH family protein
OMERI08G12930.1bHLH family protein
OMERI08G14480.1bHLH family protein
OMERI08G14790.1bHLH family protein
OMERI08G14850.1bHLH family protein
OMERI08G16700.1bHLH family protein
OMERI08G17270.1bHLH family protein
OMERI09G07780.1bHLH family protein
OMERI09G08190.1bHLH family protein
OMERI09G10060.1bHLH family protein
OMERI09G10230.1bHLH family protein
OMERI09G10430.1bHLH family protein
OMERI09G10560.2bHLH family protein
OMERI09G10560.3bHLH family protein
OMERI09G10560.4bHLH family protein
OMERI09G10560.5bHLH family protein
OMERI09G10560.6bHLH family protein
OMERI09G10560.7bHLH family protein
OMERI09G11370.6bHLH family protein
OMERI09G11370.7bHLH family protein
OMERI09G11890.1bHLH family protein
OMERI10G06540.1bHLH family protein
OMERI10G06590.1bHLH family protein
OMERI10G08610.4bHLH family protein
OMERI10G08610.5bHLH family protein
OMERI10G13920.1bHLH family protein
OMERI10G14830.1bHLH family protein
OMERI11G02310.1bHLH family protein
OMERI11G03460.1bHLH family protein
OMERI11G10380.1bHLH family protein
OMERI11G10380.2bHLH family protein
OMERI11G10380.3bHLH family protein
OMERI11G12580.1bHLH family protein
OMERI12G12030.1bHLH family protein
OMERI12G12400.1bHLH family protein
OMERI12G12420.1bHLH family protein
OMERI12G13210.1bHLH family protein
OMERI12G15000.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250