PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza meridionalis
MIKC_MADS Family
Species TF ID Description
OMERI01G06630.1MIKC_MADS family protein
OMERI01G06630.2MIKC_MADS family protein
OMERI01G06630.3MIKC_MADS family protein
OMERI01G06630.4MIKC_MADS family protein
OMERI01G06630.5MIKC_MADS family protein
OMERI01G36400.1MIKC_MADS family protein
OMERI01G36640.1MIKC_MADS family protein
OMERI01G36640.2MIKC_MADS family protein
OMERI02G06250.1MIKC_MADS family protein
OMERI02G09250.1MIKC_MADS family protein
OMERI02G21410.1MIKC_MADS family protein
OMERI02G27210.1MIKC_MADS family protein
OMERI02G27210.2MIKC_MADS family protein
OMERI02G27210.3MIKC_MADS family protein
OMERI02G27210.4MIKC_MADS family protein
OMERI02G30060.1MIKC_MADS family protein
OMERI02G30060.2MIKC_MADS family protein
OMERI02G31880.1MIKC_MADS family protein
OMERI03G01730.1MIKC_MADS family protein
OMERI03G01730.2MIKC_MADS family protein
OMERI03G01730.4MIKC_MADS family protein
OMERI03G06190.1MIKC_MADS family protein
OMERI03G08080.1MIKC_MADS family protein
OMERI03G08080.2MIKC_MADS family protein
OMERI03G31620.1MIKC_MADS family protein
OMERI03G31620.2MIKC_MADS family protein
OMERI03G31620.3MIKC_MADS family protein
OMERI03G31620.4MIKC_MADS family protein
OMERI03G31620.5MIKC_MADS family protein
OMERI03G31620.6MIKC_MADS family protein
OMERI04G12400.1MIKC_MADS family protein
OMERI04G12420.1MIKC_MADS family protein
OMERI04G19060.1MIKC_MADS family protein
OMERI04G19060.2MIKC_MADS family protein
OMERI04G19060.3MIKC_MADS family protein
OMERI04G20840.2MIKC_MADS family protein
OMERI04G20840.3MIKC_MADS family protein
OMERI05G05900.1MIKC_MADS family protein
OMERI05G05900.2MIKC_MADS family protein
OMERI05G14780.1MIKC_MADS family protein
OMERI05G14780.2MIKC_MADS family protein
OMERI06G00470.1MIKC_MADS family protein
OMERI06G04850.1MIKC_MADS family protein
OMERI06G08590.1MIKC_MADS family protein
OMERI06G08590.2MIKC_MADS family protein
OMERI06G08590.3MIKC_MADS family protein
OMERI06G08590.4MIKC_MADS family protein
OMERI06G13620.1MIKC_MADS family protein
OMERI06G13620.2MIKC_MADS family protein
OMERI06G13620.3MIKC_MADS family protein
OMERI06G13620.4MIKC_MADS family protein
OMERI06G13620.5MIKC_MADS family protein
OMERI06G13650.1MIKC_MADS family protein
OMERI06G13650.2MIKC_MADS family protein
OMERI06G24380.1MIKC_MADS family protein
OMERI06G27290.1MIKC_MADS family protein
OMERI07G00180.1MIKC_MADS family protein
OMERI07G04970.1MIKC_MADS family protein
OMERI07G17960.1MIKC_MADS family protein
OMERI07G17960.2MIKC_MADS family protein
OMERI07G17960.3MIKC_MADS family protein
OMERI07G17960.4MIKC_MADS family protein
OMERI08G12880.1MIKC_MADS family protein
OMERI10G13430.1MIKC_MADS family protein
OMERI12G04030.1MIKC_MADS family protein
OMERI12G04040.1MIKC_MADS family protein
OMERI12G08970.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513