PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza brachyantha
bHLH Family
Species TF ID Description
OB0081G10010.1bHLH family protein
OB0197G10010.1bHLH family protein
OB01G10340.1bHLH family protein
OB01G10560.1bHLH family protein
OB01G10850.1bHLH family protein
OB01G13800.1bHLH family protein
OB01G16120.1bHLH family protein
OB01G17480.1bHLH family protein
OB01G18800.1bHLH family protein
OB01G21830.1bHLH family protein
OB01G22030.1bHLH family protein
OB01G30040.1bHLH family protein
OB01G30110.1bHLH family protein
OB01G37310.1bHLH family protein
OB01G42230.1bHLH family protein
OB01G47090.1bHLH family protein
OB01G49420.1bHLH family protein
OB01G50400.1bHLH family protein
OB01G53300.1bHLH family protein
OB02G18580.1bHLH family protein
OB02G19900.1bHLH family protein
OB02G27530.1bHLH family protein
OB02G28530.1bHLH family protein
OB02G30670.1bHLH family protein
OB02G35790.1bHLH family protein
OB02G36640.1bHLH family protein
OB02G36990.1bHLH family protein
OB02G38020.1bHLH family protein
OB02G39450.1bHLH family protein
OB02G40170.1bHLH family protein
OB02G42630.1bHLH family protein
OB02G43130.1bHLH family protein
OB03G11710.1bHLH family protein
OB03G12820.1bHLH family protein
OB03G15440.1bHLH family protein
OB03G15490.1bHLH family protein
OB03G16590.1bHLH family protein
OB03G17860.1bHLH family protein
OB03G19470.1bHLH family protein
OB03G19600.1bHLH family protein
OB03G21490.1bHLH family protein
OB03G22680.1bHLH family protein
OB03G28630.1bHLH family protein
OB03G29280.1bHLH family protein
OB03G34210.1bHLH family protein
OB03G34880.1bHLH family protein
OB03G36500.1bHLH family protein
OB03G36530.1bHLH family protein
OB03G39890.1bHLH family protein
OB03G40700.1bHLH family protein
OB03G41880.1bHLH family protein
OB03G42180.1bHLH family protein
OB03G43250.1bHLH family protein
OB03G44670.1bHLH family protein
OB03G45440.1bHLH family protein
OB04G15330.1bHLH family protein
OB04G16610.1bHLH family protein
OB04G17410.1bHLH family protein
OB04G19930.1bHLH family protein
OB04G19940.1bHLH family protein
OB04G24170.1bHLH family protein
OB04G28350.1bHLH family protein
OB04G28380.1bHLH family protein
OB04G28390.1bHLH family protein
OB04G28860.1bHLH family protein
OB04G30380.1bHLH family protein
OB04G30880.1bHLH family protein
OB04G32400.1bHLH family protein
OB04G33270.1bHLH family protein
OB04G33830.1bHLH family protein
OB05G10240.1bHLH family protein
OB05G12600.1bHLH family protein
OB05G13810.1bHLH family protein
OB05G14140.1bHLH family protein
OB05G15870.1bHLH family protein
OB05G26550.1bHLH family protein
OB05G29420.1bHLH family protein
OB05G31840.1bHLH family protein
OB05G34990.1bHLH family protein
OB05G35750.1bHLH family protein
OB06G13990.1bHLH family protein
OB06G14990.1bHLH family protein
OB06G15580.1bHLH family protein
OB06G17570.1bHLH family protein
OB06G19820.1bHLH family protein
OB06G24700.1bHLH family protein
OB06G28840.1bHLH family protein
OB06G35590.1bHLH family protein
OB07G10150.1bHLH family protein
OB07G12160.1bHLH family protein
OB07G13990.1bHLH family protein
OB07G14260.1bHLH family protein
OB07G14580.1bHLH family protein
OB07G15330.1bHLH family protein
OB07G23510.1bHLH family protein
OB07G23820.1bHLH family protein
OB07G26210.1bHLH family protein
OB07G28610.1bHLH family protein
OB08G10720.1bHLH family protein
OB08G12550.1bHLH family protein
OB08G14900.1bHLH family protein
OB08G25230.1bHLH family protein
OB08G25610.1bHLH family protein
OB08G25860.1bHLH family protein
OB08G25940.1bHLH family protein
OB08G26810.1bHLH family protein
OB08G27870.1bHLH family protein
OB08G28640.1bHLH family protein
OB09G16590.1bHLH family protein
OB09G16940.1bHLH family protein
OB09G19960.1bHLH family protein
OB09G20330.1bHLH family protein
OB09G20380.1bHLH family protein
OB09G21960.1bHLH family protein
OB09G22630.1bHLH family protein
OB10G13050.1bHLH family protein
OB10G16200.1bHLH family protein
OB10G17210.1bHLH family protein
OB10G17240.1bHLH family protein
OB10G25310.1bHLH family protein
OB11G13170.1bHLH family protein
OB11G19520.1bHLH family protein
OB11G24570.1bHLH family protein
OB11G24670.1bHLH family protein
OB11G25500.1bHLH family protein
OB12G20560.1bHLH family protein
OB12G24200.1bHLH family protein
OB12G24620.1bHLH family protein
OB12G24630.1bHLH family protein
OB12G24640.1bHLH family protein
OB12G25120.1bHLH family protein
OB12G26450.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250