PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Oryza barthii
MIKC_MADS Family
Species TF ID Description
OBART01G06520.1MIKC_MADS family protein
OBART01G29490.1MIKC_MADS family protein
OBART01G29490.2MIKC_MADS family protein
OBART01G39540.1MIKC_MADS family protein
OBART01G39740.1MIKC_MADS family protein
OBART01G39740.2MIKC_MADS family protein
OBART02G00360.1MIKC_MADS family protein
OBART02G05380.1MIKC_MADS family protein
OBART02G05380.2MIKC_MADS family protein
OBART02G21870.1MIKC_MADS family protein
OBART02G21870.2MIKC_MADS family protein
OBART02G28030.1MIKC_MADS family protein
OBART02G31280.1MIKC_MADS family protein
OBART02G31280.2MIKC_MADS family protein
OBART02G33400.1MIKC_MADS family protein
OBART02G33400.2MIKC_MADS family protein
OBART03G06320.1MIKC_MADS family protein
OBART03G08330.2MIKC_MADS family protein
OBART03G34520.1MIKC_MADS family protein
OBART03G34520.2MIKC_MADS family protein
OBART03G34530.1MIKC_MADS family protein
OBART04G07050.1MIKC_MADS family protein
OBART04G13770.1MIKC_MADS family protein
OBART04G13800.1MIKC_MADS family protein
OBART04G22790.1MIKC_MADS family protein
OBART04G22790.2MIKC_MADS family protein
OBART04G25610.1MIKC_MADS family protein
OBART05G06590.1MIKC_MADS family protein
OBART05G06600.1MIKC_MADS family protein
OBART05G17040.1MIKC_MADS family protein
OBART06G04180.1MIKC_MADS family protein
OBART06G24100.1MIKC_MADS family protein
OBART06G27230.1MIKC_MADS family protein
OBART07G00700.1MIKC_MADS family protein
OBART07G00700.2MIKC_MADS family protein
OBART07G21550.1MIKC_MADS family protein
OBART08G00930.1MIKC_MADS family protein
OBART08G15610.1MIKC_MADS family protein
OBART08G15610.3MIKC_MADS family protein
OBART08G21550.1MIKC_MADS family protein
OBART08G21550.2MIKC_MADS family protein
OBART08G21550.3MIKC_MADS family protein
OBART08G21550.4MIKC_MADS family protein
OBART08G21560.1MIKC_MADS family protein
OBART09G15760.1MIKC_MADS family protein
OBART09G15760.2MIKC_MADS family protein
OBART10G16960.1MIKC_MADS family protein
OBART10G16960.2MIKC_MADS family protein
OBART10G16960.3MIKC_MADS family protein
OBART12G05930.1MIKC_MADS family protein
OBART12G05940.1MIKC_MADS family protein
OBART12G05940.2MIKC_MADS family protein
OBART12G05940.3MIKC_MADS family protein
OBART12G13000.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513