PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana tomentosiformis
NF-YA Family
Species TF ID Description
XP_009592750.1NF-YA family protein
XP_009592751.1NF-YA family protein
XP_009592752.1NF-YA family protein
XP_009592753.1NF-YA family protein
XP_009599539.1NF-YA family protein
XP_009608878.1NF-YA family protein
XP_009608879.1NF-YA family protein
XP_009608880.1NF-YA family protein
XP_009608882.1NF-YA family protein
XP_009608945.1NF-YA family protein
XP_009608946.1NF-YA family protein
XP_009608947.1NF-YA family protein
XP_009613978.1NF-YA family protein
XP_009616281.1NF-YA family protein
XP_009616282.1NF-YA family protein
XP_009616283.1NF-YA family protein
XP_009616284.1NF-YA family protein
XP_009616285.1NF-YA family protein
XP_009616286.1NF-YA family protein
XP_009617196.1NF-YA family protein
XP_009617197.1NF-YA family protein
XP_009617198.1NF-YA family protein
XP_009617199.1NF-YA family protein
XP_009624416.1NF-YA family protein
XP_009624418.1NF-YA family protein
XP_009626580.1NF-YA family protein
XP_009626581.1NF-YA family protein
XP_009626582.1NF-YA family protein
XP_009631340.1NF-YA family protein
XP_009631347.1NF-YA family protein
XP_009631356.1NF-YA family protein
XP_009631363.1NF-YA family protein
XP_009632036.1NF-YA family protein
NF-YA Family Introduction

NF-Y transcription factors are likely found in all eukaryotes and have roles in the regulation of diverse genes (McNabb et al., 1995; Edwards et al., 1998; Maity and de Crombrugghe, 1998; Mantovani, 1999). In mammals, where their biochemistry is well described, the NF-Y transcription factor complex is composed of three unique subunits: NF-YA, NF-YB, and NF-YC. Assembly of the NF-Y heterotrimer in mammals follows a strict, stepwise pattern (Sinha et al., 1995, 1996). Initially, a heterodimer is formed in the cytoplasm between the subunits NF-YB and NF-YC. This dimer then translocates to the nucleus, where the third subunit, NF-YA, is recruited to generate the mature, heterotrimeric NF-Y transcription factor (Frontini et al., 2004; Kahle et al., 2005). Mature NF-Y binds promoters with the core pentamer nucleotide sequence CCAAT, and this can result in either positive or negative transcriptional regulation(Peng and Jahroudi, 2002, 2003; Ceribelli et al., 2008).

NF-YA proteins are characterized by the presence of Gln(Q)- and Ser/Thr(S/T)-rich NH2 termini, a subunit interaction domain (NF-YB/NF-YC interaction), and a DNA-binding domain (Olesen and Guarente, 1990; Maity and de Crombrugghe, 1992; Xing et al., 1993, 1994). The protein interaction and DNA binding domains are well conserved between plant and other eukaryote lineages.

Siefers N, Dang KK, Kumimoto RW, Bynum WE 4th, Tayrose G, Holt BF 3rd.
Tissue-specific expression patterns of Arabidopsis NF-Y transcription factors suggest potential for extensive combinatorial complexity.
Plant Physiol, 2009. 149(2): p. 625-41.
PMID: 19019982