PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana tomentosiformis
M-type_MADS Family
Species TF ID Description
XP_009586738.1M-type_MADS family protein
XP_009587873.1M-type_MADS family protein
XP_009593028.1M-type_MADS family protein
XP_009593754.1M-type_MADS family protein
XP_009593755.1M-type_MADS family protein
XP_009593756.1M-type_MADS family protein
XP_009593757.1M-type_MADS family protein
XP_009593982.1M-type_MADS family protein
XP_009593983.1M-type_MADS family protein
XP_009593984.1M-type_MADS family protein
XP_009595132.1M-type_MADS family protein
XP_009595152.1M-type_MADS family protein
XP_009595185.1M-type_MADS family protein
XP_009596094.1M-type_MADS family protein
XP_009597071.1M-type_MADS family protein
XP_009597191.1M-type_MADS family protein
XP_009597574.1M-type_MADS family protein
XP_009597641.1M-type_MADS family protein
XP_009597802.1M-type_MADS family protein
XP_009598741.1M-type_MADS family protein
XP_009598941.1M-type_MADS family protein
XP_009599004.1M-type_MADS family protein
XP_009599183.1M-type_MADS family protein
XP_009599347.1M-type_MADS family protein
XP_009599348.1M-type_MADS family protein
XP_009599349.1M-type_MADS family protein
XP_009599455.1M-type_MADS family protein
XP_009599507.1M-type_MADS family protein
XP_009600724.1M-type_MADS family protein
XP_009601691.1M-type_MADS family protein
XP_009601694.1M-type_MADS family protein
XP_009601728.1M-type_MADS family protein
XP_009602802.1M-type_MADS family protein
XP_009602824.1M-type_MADS family protein
XP_009603478.1M-type_MADS family protein
XP_009603899.1M-type_MADS family protein
XP_009605702.1M-type_MADS family protein
XP_009607102.1M-type_MADS family protein
XP_009608097.1M-type_MADS family protein
XP_009608098.1M-type_MADS family protein
XP_009609250.1M-type_MADS family protein
XP_009610476.1M-type_MADS family protein
XP_009612339.1M-type_MADS family protein
XP_009612340.1M-type_MADS family protein
XP_009612707.1M-type_MADS family protein
XP_009614179.1M-type_MADS family protein
XP_009615159.1M-type_MADS family protein
XP_009615322.1M-type_MADS family protein
XP_009616563.1M-type_MADS family protein
XP_009616634.1M-type_MADS family protein
XP_009617106.1M-type_MADS family protein
XP_009617259.1M-type_MADS family protein
XP_009617678.1M-type_MADS family protein
XP_009617757.1M-type_MADS family protein
XP_009617758.1M-type_MADS family protein
XP_009618268.1M-type_MADS family protein
XP_009618312.1M-type_MADS family protein
XP_009618313.1M-type_MADS family protein
XP_009618478.1M-type_MADS family protein
XP_009618561.1M-type_MADS family protein
XP_009619329.1M-type_MADS family protein
XP_009620199.1M-type_MADS family protein
XP_009620978.1M-type_MADS family protein
XP_009621249.1M-type_MADS family protein
XP_009621899.1M-type_MADS family protein
XP_009622555.1M-type_MADS family protein
XP_009623377.1M-type_MADS family protein
XP_009623634.1M-type_MADS family protein
XP_009623635.1M-type_MADS family protein
XP_009624741.1M-type_MADS family protein
XP_009624846.1M-type_MADS family protein
XP_009626363.1M-type_MADS family protein
XP_009626530.1M-type_MADS family protein
XP_009626927.1M-type_MADS family protein
XP_009627466.1M-type_MADS family protein
XP_009628464.1M-type_MADS family protein
XP_009628581.1M-type_MADS family protein
XP_009630258.1M-type_MADS family protein
XP_009630259.1M-type_MADS family protein
XP_009630756.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513