PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tomentosiformis
HD-ZIP Family
Species TF ID Description
XP_009622827.1HD-ZIP family protein
XP_009593379.1HD-ZIP family protein
XP_009624441.1HD-ZIP family protein
XP_009624442.1HD-ZIP family protein
XP_009598097.1HD-ZIP family protein
XP_009591685.1HD-ZIP family protein
XP_009590186.1HD-ZIP family protein
XP_009604044.1HD-ZIP family protein
XP_009604043.1HD-ZIP family protein
XP_009589459.1HD-ZIP family protein
XP_009631939.1HD-ZIP family protein
XP_009588928.1HD-ZIP family protein
XP_009631938.1HD-ZIP family protein
XP_009617361.1HD-ZIP family protein
XP_009604803.1HD-ZIP family protein
XP_009604802.1HD-ZIP family protein
XP_009604990.1HD-ZIP family protein
XP_009619639.1HD-ZIP family protein
XP_009592889.1HD-ZIP family protein
XP_009610614.1HD-ZIP family protein
XP_009588530.1HD-ZIP family protein
XP_009587238.1HD-ZIP family protein
XP_009588531.1HD-ZIP family protein
XP_009588532.1HD-ZIP family protein
XP_009588533.1HD-ZIP family protein
XP_009588534.1HD-ZIP family protein
XP_009629706.1HD-ZIP family protein
XP_009590483.1HD-ZIP family protein
XP_009590779.1HD-ZIP family protein
XP_009612669.1HD-ZIP family protein
XP_009587939.1HD-ZIP family protein
XP_009594284.1HD-ZIP family protein
XP_009611805.1HD-ZIP family protein
XP_009601707.1HD-ZIP family protein
XP_009605338.1HD-ZIP family protein
XP_009600601.1HD-ZIP family protein
XP_009630679.1HD-ZIP family protein
XP_009611399.1HD-ZIP family protein
XP_009604991.1HD-ZIP family protein
XP_009604988.1HD-ZIP family protein
XP_009604989.1HD-ZIP family protein
XP_009608121.1HD-ZIP family protein
XP_009631116.1HD-ZIP family protein
XP_009591846.1HD-ZIP family protein
XP_009598333.1HD-ZIP family protein
XP_009598326.1HD-ZIP family protein
XP_009605863.1HD-ZIP family protein
XP_009605864.1HD-ZIP family protein
XP_009611249.1HD-ZIP family protein
XP_009611248.1HD-ZIP family protein
XP_009609608.1HD-ZIP family protein
XP_009609609.1HD-ZIP family protein
XP_009609610.1HD-ZIP family protein
XP_009609606.1HD-ZIP family protein
XP_009592773.1HD-ZIP family protein
XP_009592772.1HD-ZIP family protein
XP_009597904.1HD-ZIP family protein
XP_009611638.1HD-ZIP family protein
XP_009611623.1HD-ZIP family protein
XP_009611633.1HD-ZIP family protein
XP_009602857.1HD-ZIP family protein
XP_009602856.1HD-ZIP family protein
XP_009629763.1HD-ZIP family protein
XP_009629762.1HD-ZIP family protein
XP_009629760.1HD-ZIP family protein
XP_009629761.1HD-ZIP family protein
XP_009587298.1HD-ZIP family protein
XP_009600774.1HD-ZIP family protein
XP_009626659.1HD-ZIP family protein
XP_009611250.1HD-ZIP family protein
XP_009606250.1HD-ZIP family protein
XP_009593967.1HD-ZIP family protein
XP_009593968.1HD-ZIP family protein
XP_009612342.1HD-ZIP family protein
XP_009612341.1HD-ZIP family protein
XP_009589494.1HD-ZIP family protein
XP_009606534.1HD-ZIP family protein
XP_009606533.1HD-ZIP family protein
XP_009606532.1HD-ZIP family protein
XP_009624234.1HD-ZIP family protein
XP_009624236.1HD-ZIP family protein
XP_009597691.1HD-ZIP family protein
XP_009597692.1HD-ZIP family protein
XP_009597693.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401