PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tomentosiformis
FAR1 Family
Species TF ID Description
XP_009587945.1FAR1 family protein
XP_009588261.1FAR1 family protein
XP_009591584.1FAR1 family protein
XP_009591935.1FAR1 family protein
XP_009591996.1FAR1 family protein
XP_009594633.1FAR1 family protein
XP_009599705.1FAR1 family protein
XP_009600660.1FAR1 family protein
XP_009600661.1FAR1 family protein
XP_009600662.1FAR1 family protein
XP_009600663.1FAR1 family protein
XP_009600664.1FAR1 family protein
XP_009600665.1FAR1 family protein
XP_009600666.1FAR1 family protein
XP_009600667.1FAR1 family protein
XP_009600668.1FAR1 family protein
XP_009601134.1FAR1 family protein
XP_009601135.1FAR1 family protein
XP_009601136.1FAR1 family protein
XP_009601478.1FAR1 family protein
XP_009601479.1FAR1 family protein
XP_009601480.1FAR1 family protein
XP_009605654.1FAR1 family protein
XP_009605655.1FAR1 family protein
XP_009605656.1FAR1 family protein
XP_009605657.1FAR1 family protein
XP_009605658.1FAR1 family protein
XP_009609279.1FAR1 family protein
XP_009609280.1FAR1 family protein
XP_009609281.1FAR1 family protein
XP_009610340.1FAR1 family protein
XP_009610341.1FAR1 family protein
XP_009610342.1FAR1 family protein
XP_009612458.1FAR1 family protein
XP_009613191.1FAR1 family protein
XP_009613192.1FAR1 family protein
XP_009613193.1FAR1 family protein
XP_009613194.1FAR1 family protein
XP_009613195.1FAR1 family protein
XP_009613196.1FAR1 family protein
XP_009613197.1FAR1 family protein
XP_009613198.1FAR1 family protein
XP_009615170.1FAR1 family protein
XP_009616992.1FAR1 family protein
XP_009616993.1FAR1 family protein
XP_009616995.1FAR1 family protein
XP_009616996.1FAR1 family protein
XP_009616997.1FAR1 family protein
XP_009616998.1FAR1 family protein
XP_009616999.1FAR1 family protein
XP_009618368.1FAR1 family protein
XP_009618369.1FAR1 family protein
XP_009618370.1FAR1 family protein
XP_009618371.1FAR1 family protein
XP_009618372.1FAR1 family protein
XP_009618373.1FAR1 family protein
XP_009618387.1FAR1 family protein
XP_009618573.1FAR1 family protein
XP_009618574.1FAR1 family protein
XP_009618575.1FAR1 family protein
XP_009618576.1FAR1 family protein
XP_009618577.1FAR1 family protein
XP_009618578.1FAR1 family protein
XP_009619707.1FAR1 family protein
XP_009620425.1FAR1 family protein
XP_009620431.1FAR1 family protein
XP_009620541.1FAR1 family protein
XP_009620542.1FAR1 family protein
XP_009620543.1FAR1 family protein
XP_009620544.1FAR1 family protein
XP_009620545.1FAR1 family protein
XP_009620546.1FAR1 family protein
XP_009621047.1FAR1 family protein
XP_009622495.1FAR1 family protein
XP_009622559.1FAR1 family protein
XP_009623109.1FAR1 family protein
XP_009624952.1FAR1 family protein
XP_009624953.1FAR1 family protein
XP_009626414.1FAR1 family protein
XP_009626415.1FAR1 family protein
XP_009626417.1FAR1 family protein
XP_009628426.1FAR1 family protein
XP_009628526.1FAR1 family protein
XP_009631083.1FAR1 family protein
XP_009631084.1FAR1 family protein
XP_009631085.1FAR1 family protein
XP_009631560.1FAR1 family protein
XP_009631561.1FAR1 family protein
XP_009631865.1FAR1 family protein
FAR1 Family Introduction

We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.

We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the "a" fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5'-TTCACGCGCC-3'. Mutating the core sequence "CACGCGC" of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, "CACGCGC" likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.

Lin R, Ding L, Casola C, Ripoll DR, Feschotte C, Wang H.
Transposase-derived transcription factors regulate light signaling in Arabidopsis.
Science, 2007. 318(5854): p. 1302-5.
PMID: 18033885