PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
bHLH Family
Species TF ID Description
XP_016432594.1bHLH family protein
XP_016432620.1bHLH family protein
XP_016432768.1bHLH family protein
XP_016433537.1bHLH family protein
XP_016433545.1bHLH family protein
XP_016433673.1bHLH family protein
XP_016433676.1bHLH family protein
XP_016433923.1bHLH family protein
XP_016434189.1bHLH family protein
XP_016434190.1bHLH family protein
XP_016434421.1bHLH family protein
XP_016434433.1bHLH family protein
XP_016434460.1bHLH family protein
XP_016435053.1bHLH family protein
XP_016435054.1bHLH family protein
XP_016435055.1bHLH family protein
XP_016435311.1bHLH family protein
XP_016435398.1bHLH family protein
XP_016435399.1bHLH family protein
XP_016435691.1bHLH family protein
XP_016435831.1bHLH family protein
XP_016437313.1bHLH family protein
XP_016437360.1bHLH family protein
XP_016437700.1bHLH family protein
XP_016437770.1bHLH family protein
XP_016438422.1bHLH family protein
XP_016438423.1bHLH family protein
XP_016438424.1bHLH family protein
XP_016438426.1bHLH family protein
XP_016438427.1bHLH family protein
XP_016438666.1bHLH family protein
XP_016439542.1bHLH family protein
XP_016439543.1bHLH family protein
XP_016439647.1bHLH family protein
XP_016439723.1bHLH family protein
XP_016439767.1bHLH family protein
XP_016440060.1bHLH family protein
XP_016440077.1bHLH family protein
XP_016440597.1bHLH family protein
XP_016441121.1bHLH family protein
XP_016441449.1bHLH family protein
XP_016441896.1bHLH family protein
XP_016442231.1bHLH family protein
XP_016442441.1bHLH family protein
XP_016442530.1bHLH family protein
XP_016443360.1bHLH family protein
XP_016443488.1bHLH family protein
XP_016443824.1bHLH family protein
XP_016443890.1bHLH family protein
XP_016443891.1bHLH family protein
XP_016443892.1bHLH family protein
XP_016444111.1bHLH family protein
XP_016444112.1bHLH family protein
XP_016444149.1bHLH family protein
XP_016444178.1bHLH family protein
XP_016444448.1bHLH family protein
XP_016445296.1bHLH family protein
XP_016445445.1bHLH family protein
XP_016446538.1bHLH family protein
XP_016446601.1bHLH family protein
XP_016446700.1bHLH family protein
XP_016447869.1bHLH family protein
XP_016448094.1bHLH family protein
XP_016448128.1bHLH family protein
XP_016448135.1bHLH family protein
XP_016448229.1bHLH family protein
XP_016448530.1bHLH family protein
XP_016448531.1bHLH family protein
XP_016448572.1bHLH family protein
XP_016448870.1bHLH family protein
XP_016449248.1bHLH family protein
XP_016449298.1bHLH family protein
XP_016449299.1bHLH family protein
XP_016449552.1bHLH family protein
XP_016449592.1bHLH family protein
XP_016449593.1bHLH family protein
XP_016449827.1bHLH family protein
XP_016450528.1bHLH family protein
XP_016450667.1bHLH family protein
XP_016450712.1bHLH family protein
XP_016451322.1bHLH family protein
XP_016451818.1bHLH family protein
XP_016452303.1bHLH family protein
XP_016452305.1bHLH family protein
XP_016452552.1bHLH family protein
XP_016452553.1bHLH family protein
XP_016452590.1bHLH family protein
XP_016453059.1bHLH family protein
XP_016453500.1bHLH family protein
XP_016453539.1bHLH family protein
XP_016453648.1bHLH family protein
XP_016453733.1bHLH family protein
XP_016453734.1bHLH family protein
XP_016453786.1bHLH family protein
XP_016453820.1bHLH family protein
XP_016454412.1bHLH family protein
XP_016454613.1bHLH family protein
XP_016454735.1bHLH family protein
XP_016456067.1bHLH family protein
XP_016456084.1bHLH family protein
XP_016456385.1bHLH family protein
XP_016456410.1bHLH family protein
XP_016456456.1bHLH family protein
XP_016456462.1bHLH family protein
XP_016456463.1bHLH family protein
XP_016456567.1bHLH family protein
XP_016456568.1bHLH family protein
XP_016456569.1bHLH family protein
XP_016456702.1bHLH family protein
XP_016456924.1bHLH family protein
XP_016457174.1bHLH family protein
XP_016457175.1bHLH family protein
XP_016457676.1bHLH family protein
XP_016457771.1bHLH family protein
XP_016457776.1bHLH family protein
XP_016458271.1bHLH family protein
XP_016459007.1bHLH family protein
XP_016459177.1bHLH family protein
XP_016459441.1bHLH family protein
XP_016459442.1bHLH family protein
XP_016459961.1bHLH family protein
XP_016459962.1bHLH family protein
XP_016460036.1bHLH family protein
XP_016460188.1bHLH family protein
XP_016460290.1bHLH family protein
XP_016461012.1bHLH family protein
XP_016461230.1bHLH family protein
XP_016461568.1bHLH family protein
XP_016461574.1bHLH family protein
XP_016461736.1bHLH family protein
XP_016461836.1bHLH family protein
XP_016461897.1bHLH family protein
XP_016462078.1bHLH family protein
XP_016462079.1bHLH family protein
XP_016462125.1bHLH family protein
XP_016462126.1bHLH family protein
XP_016462240.1bHLH family protein
XP_016462318.1bHLH family protein
XP_016462319.1bHLH family protein
XP_016462348.1bHLH family protein
XP_016462422.1bHLH family protein
XP_016462423.1bHLH family protein
XP_016462439.1bHLH family protein
XP_016462596.1bHLH family protein
XP_016463822.1bHLH family protein
XP_016464527.1bHLH family protein
XP_016464627.1bHLH family protein
XP_016464628.1bHLH family protein
XP_016464651.1bHLH family protein
XP_016464652.1bHLH family protein
XP_016464653.1bHLH family protein
XP_016464860.1bHLH family protein
XP_016465220.1bHLH family protein
XP_016465310.1bHLH family protein
XP_016465585.1bHLH family protein
XP_016465880.1bHLH family protein
XP_016465934.1bHLH family protein
XP_016465935.1bHLH family protein
XP_016465936.1bHLH family protein
XP_016466260.1bHLH family protein
XP_016466261.1bHLH family protein
XP_016466262.1bHLH family protein
XP_016466263.1bHLH family protein
XP_016466430.1bHLH family protein
XP_016466432.1bHLH family protein
XP_016466664.1bHLH family protein
XP_016466665.1bHLH family protein
XP_016467241.1bHLH family protein
XP_016468020.1bHLH family protein
XP_016468021.1bHLH family protein
XP_016468176.1bHLH family protein
XP_016468704.1bHLH family protein
XP_016468834.1bHLH family protein
XP_016468835.1bHLH family protein
XP_016469195.1bHLH family protein
XP_016469228.1bHLH family protein
XP_016469253.1bHLH family protein
XP_016469255.1bHLH family protein
XP_016469256.1bHLH family protein
XP_016469257.1bHLH family protein
XP_016469294.1bHLH family protein
XP_016469364.1bHLH family protein
XP_016469426.1bHLH family protein
XP_016469430.1bHLH family protein
XP_016469681.1bHLH family protein
XP_016469768.1bHLH family protein
XP_016469787.1bHLH family protein
XP_016469953.1bHLH family protein
XP_016470015.1bHLH family protein
XP_016470861.1bHLH family protein
XP_016471010.1bHLH family protein
XP_016471011.1bHLH family protein
XP_016471157.1bHLH family protein
XP_016471158.1bHLH family protein
XP_016471159.1bHLH family protein
XP_016471160.1bHLH family protein
XP_016471316.1bHLH family protein
XP_016471375.1bHLH family protein
XP_016471633.1bHLH family protein
XP_016471744.1bHLH family protein
XP_016471803.1bHLH family protein
XP_016471804.1bHLH family protein
XP_016472308.1bHLH family protein
XP_016472309.1bHLH family protein
XP_016473138.1bHLH family protein
XP_016473139.1bHLH family protein
XP_016473140.1bHLH family protein
XP_016473141.1bHLH family protein
XP_016473149.1bHLH family protein
XP_016473150.1bHLH family protein
XP_016473886.1bHLH family protein
XP_016474387.1bHLH family protein
XP_016474389.1bHLH family protein
XP_016474563.1bHLH family protein
XP_016474564.1bHLH family protein
XP_016474565.1bHLH family protein
XP_016474795.1bHLH family protein
XP_016475053.1bHLH family protein
XP_016475054.1bHLH family protein
XP_016475055.1bHLH family protein
XP_016475213.1bHLH family protein
XP_016475217.1bHLH family protein
XP_016475478.1bHLH family protein
XP_016475882.1bHLH family protein
XP_016475963.1bHLH family protein
XP_016476167.1bHLH family protein
XP_016476579.1bHLH family protein
XP_016476596.1bHLH family protein
XP_016476813.1bHLH family protein
XP_016477044.1bHLH family protein
XP_016477045.1bHLH family protein
XP_016477426.1bHLH family protein
XP_016477458.1bHLH family protein
XP_016477459.1bHLH family protein
XP_016477727.1bHLH family protein
XP_016477918.1bHLH family protein
XP_016478079.1bHLH family protein
XP_016478334.1bHLH family protein
XP_016478335.1bHLH family protein
XP_016478354.1bHLH family protein
XP_016478979.1bHLH family protein
XP_016478981.1bHLH family protein
XP_016478982.1bHLH family protein
XP_016479216.1bHLH family protein
XP_016479511.1bHLH family protein
XP_016479713.1bHLH family protein
XP_016480020.1bHLH family protein
XP_016480480.1bHLH family protein
XP_016480568.1bHLH family protein
XP_016481151.1bHLH family protein
XP_016481157.1bHLH family protein
XP_016481164.1bHLH family protein
XP_016481169.1bHLH family protein
XP_016481890.1bHLH family protein
XP_016482586.1bHLH family protein
XP_016483015.1bHLH family protein
XP_016483155.1bHLH family protein
XP_016483156.1bHLH family protein
XP_016483157.1bHLH family protein
XP_016483876.1bHLH family protein
XP_016483877.1bHLH family protein
XP_016483878.1bHLH family protein
XP_016483879.1bHLH family protein
XP_016484096.1bHLH family protein
XP_016484240.1bHLH family protein
XP_016484581.1bHLH family protein
XP_016484582.1bHLH family protein
XP_016484583.1bHLH family protein
XP_016484656.1bHLH family protein
XP_016484705.1bHLH family protein
XP_016484862.1bHLH family protein
XP_016484893.1bHLH family protein
XP_016485356.1bHLH family protein
XP_016485602.1bHLH family protein
XP_016486002.1bHLH family protein
XP_016486152.1bHLH family protein
XP_016486370.1bHLH family protein
XP_016486371.1bHLH family protein
XP_016486372.1bHLH family protein
XP_016486373.1bHLH family protein
XP_016487135.1bHLH family protein
XP_016487244.1bHLH family protein
XP_016487434.1bHLH family protein
XP_016487487.1bHLH family protein
XP_016487645.1bHLH family protein
XP_016487716.1bHLH family protein
XP_016487724.1bHLH family protein
XP_016488389.1bHLH family protein
XP_016488390.1bHLH family protein
XP_016488391.1bHLH family protein
XP_016488393.1bHLH family protein
XP_016488551.1bHLH family protein
XP_016488611.1bHLH family protein
XP_016488691.1bHLH family protein
XP_016488746.1bHLH family protein
XP_016488747.1bHLH family protein
XP_016488925.1bHLH family protein
XP_016489052.1bHLH family protein
XP_016489054.1bHLH family protein
XP_016489167.1bHLH family protein
XP_016489168.1bHLH family protein
XP_016489170.1bHLH family protein
XP_016489360.1bHLH family protein
XP_016489361.1bHLH family protein
XP_016489484.1bHLH family protein
XP_016489485.1bHLH family protein
XP_016489486.1bHLH family protein
XP_016489487.1bHLH family protein
XP_016489750.1bHLH family protein
XP_016489873.1bHLH family protein
XP_016489874.1bHLH family protein
XP_016489875.1bHLH family protein
XP_016489877.1bHLH family protein
XP_016490233.1bHLH family protein
XP_016490372.1bHLH family protein
XP_016490472.1bHLH family protein
XP_016490519.1bHLH family protein
XP_016490642.1bHLH family protein
XP_016490786.1bHLH family protein
XP_016490801.1bHLH family protein
XP_016490802.1bHLH family protein
XP_016490803.1bHLH family protein
XP_016490829.1bHLH family protein
XP_016491104.1bHLH family protein
XP_016491406.1bHLH family protein
XP_016491604.1bHLH family protein
XP_016491605.1bHLH family protein
XP_016491701.1bHLH family protein
XP_016492181.1bHLH family protein
XP_016492244.1bHLH family protein
XP_016492779.1bHLH family protein
XP_016492808.1bHLH family protein
XP_016492809.1bHLH family protein
XP_016493130.1bHLH family protein
XP_016493190.1bHLH family protein
XP_016493293.1bHLH family protein
XP_016493370.1bHLH family protein
XP_016493371.1bHLH family protein
XP_016493372.1bHLH family protein
XP_016493741.1bHLH family protein
XP_016493934.1bHLH family protein
XP_016493993.1bHLH family protein
XP_016494316.1bHLH family protein
XP_016495027.1bHLH family protein
XP_016495441.1bHLH family protein
XP_016496563.1bHLH family protein
XP_016496901.1bHLH family protein
XP_016496933.1bHLH family protein
XP_016497099.1bHLH family protein
XP_016497676.1bHLH family protein
XP_016497820.1bHLH family protein
XP_016498399.1bHLH family protein
XP_016498405.1bHLH family protein
XP_016498898.1bHLH family protein
XP_016499262.1bHLH family protein
XP_016499286.1bHLH family protein
XP_016499382.1bHLH family protein
XP_016499457.1bHLH family protein
XP_016499458.1bHLH family protein
XP_016499459.1bHLH family protein
XP_016499664.1bHLH family protein
XP_016500166.1bHLH family protein
XP_016500373.1bHLH family protein
XP_016501993.1bHLH family protein
XP_016502344.1bHLH family protein
XP_016502420.1bHLH family protein
XP_016502614.1bHLH family protein
XP_016502760.1bHLH family protein
XP_016502819.1bHLH family protein
XP_016502822.1bHLH family protein
XP_016503104.1bHLH family protein
XP_016503356.1bHLH family protein
XP_016503357.1bHLH family protein
XP_016504237.1bHLH family protein
XP_016504238.1bHLH family protein
XP_016504239.1bHLH family protein
XP_016504316.1bHLH family protein
XP_016504735.1bHLH family protein
XP_016504736.1bHLH family protein
XP_016504822.1bHLH family protein
XP_016504990.1bHLH family protein
XP_016505506.1bHLH family protein
XP_016505584.1bHLH family protein
XP_016505589.1bHLH family protein
XP_016506308.1bHLH family protein
XP_016506309.1bHLH family protein
XP_016506510.1bHLH family protein
XP_016507239.1bHLH family protein
XP_016507543.1bHLH family protein
XP_016507544.1bHLH family protein
XP_016507553.1bHLH family protein
XP_016507862.1bHLH family protein
XP_016507863.1bHLH family protein
XP_016508031.1bHLH family protein
XP_016508165.1bHLH family protein
XP_016508619.1bHLH family protein
XP_016508620.1bHLH family protein
XP_016508733.1bHLH family protein
XP_016509506.1bHLH family protein
XP_016509563.1bHLH family protein
XP_016510119.1bHLH family protein
XP_016510646.1bHLH family protein
XP_016510647.1bHLH family protein
XP_016510749.1bHLH family protein
XP_016510802.1bHLH family protein
XP_016510911.1bHLH family protein
XP_016511122.1bHLH family protein
XP_016511145.1bHLH family protein
XP_016511682.1bHLH family protein
XP_016511956.1bHLH family protein
XP_016511999.1bHLH family protein
XP_016512542.1bHLH family protein
XP_016512579.1bHLH family protein
XP_016512588.1bHLH family protein
XP_016512863.1bHLH family protein
XP_016512926.1bHLH family protein
XP_016513185.1bHLH family protein
XP_016513364.1bHLH family protein
XP_016513426.1bHLH family protein
XP_016513427.1bHLH family protein
XP_016513428.1bHLH family protein
XP_016513536.1bHLH family protein
XP_016513537.1bHLH family protein
XP_016514051.1bHLH family protein
XP_016514052.1bHLH family protein
XP_016514053.1bHLH family protein
XP_016514446.1bHLH family protein
XP_016515370.1bHLH family protein
XP_016515457.1bHLH family protein
XP_016515458.1bHLH family protein
XP_016515459.1bHLH family protein
XP_016515460.1bHLH family protein
XP_016515462.1bHLH family protein
XP_016515694.1bHLH family protein
XP_016515826.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250