PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
WOX Family
Species TF ID Description
XP_016487428.1WOX family protein
XP_016488708.1WOX family protein
XP_016474400.1WOX family protein
XP_016437977.1WOX family protein
XP_016513970.1WOX family protein
XP_016453563.1WOX family protein
XP_016493082.1WOX family protein
XP_016489389.1WOX family protein
XP_016445580.1WOX family protein
XP_016474994.1WOX family protein
XP_016479311.1WOX family protein
XP_016464869.1WOX family protein
XP_016489291.1WOX family protein
XP_016462055.1WOX family protein
XP_016462054.1WOX family protein
XP_016453095.1WOX family protein
XP_016439029.1WOX family protein
XP_016453094.1WOX family protein
XP_016487673.1WOX family protein
XP_016451703.1WOX family protein
XP_016480025.1WOX family protein
XP_016457347.1WOX family protein
XP_016470053.1WOX family protein
XP_016442227.1WOX family protein
XP_016481633.1WOX family protein
XP_016457346.1WOX family protein
XP_016457345.1WOX family protein
XP_016448467.1WOX family protein
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401


The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590