PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
MIKC_MADS Family
Species TF ID Description
XP_016432680.1MIKC_MADS family protein
XP_016432681.1MIKC_MADS family protein
XP_016434468.1MIKC_MADS family protein
XP_016434962.1MIKC_MADS family protein
XP_016435497.1MIKC_MADS family protein
XP_016435581.1MIKC_MADS family protein
XP_016435582.1MIKC_MADS family protein
XP_016435583.1MIKC_MADS family protein
XP_016435771.1MIKC_MADS family protein
XP_016435773.1MIKC_MADS family protein
XP_016436043.1MIKC_MADS family protein
XP_016438396.1MIKC_MADS family protein
XP_016438500.1MIKC_MADS family protein
XP_016438501.1MIKC_MADS family protein
XP_016440864.1MIKC_MADS family protein
XP_016441570.1MIKC_MADS family protein
XP_016441576.1MIKC_MADS family protein
XP_016441787.1MIKC_MADS family protein
XP_016441788.1MIKC_MADS family protein
XP_016441789.1MIKC_MADS family protein
XP_016441790.1MIKC_MADS family protein
XP_016442369.1MIKC_MADS family protein
XP_016442370.1MIKC_MADS family protein
XP_016442371.1MIKC_MADS family protein
XP_016442773.1MIKC_MADS family protein
XP_016442774.1MIKC_MADS family protein
XP_016443325.1MIKC_MADS family protein
XP_016443326.1MIKC_MADS family protein
XP_016443327.1MIKC_MADS family protein
XP_016445758.1MIKC_MADS family protein
XP_016445759.1MIKC_MADS family protein
XP_016447081.1MIKC_MADS family protein
XP_016447821.1MIKC_MADS family protein
XP_016447855.1MIKC_MADS family protein
XP_016447856.1MIKC_MADS family protein
XP_016448367.1MIKC_MADS family protein
XP_016448902.1MIKC_MADS family protein
XP_016448958.1MIKC_MADS family protein
XP_016449734.1MIKC_MADS family protein
XP_016449735.1MIKC_MADS family protein
XP_016449736.1MIKC_MADS family protein
XP_016449737.1MIKC_MADS family protein
XP_016449898.1MIKC_MADS family protein
XP_016451215.1MIKC_MADS family protein
XP_016451916.1MIKC_MADS family protein
XP_016451917.1MIKC_MADS family protein
XP_016451918.1MIKC_MADS family protein
XP_016452038.1MIKC_MADS family protein
XP_016452522.1MIKC_MADS family protein
XP_016453350.1MIKC_MADS family protein
XP_016456449.1MIKC_MADS family protein
XP_016456713.1MIKC_MADS family protein
XP_016457481.1MIKC_MADS family protein
XP_016462835.1MIKC_MADS family protein
XP_016462836.1MIKC_MADS family protein
XP_016462837.1MIKC_MADS family protein
XP_016465678.1MIKC_MADS family protein
XP_016465679.1MIKC_MADS family protein
XP_016466963.1MIKC_MADS family protein
XP_016466964.1MIKC_MADS family protein
XP_016466965.1MIKC_MADS family protein
XP_016466966.1MIKC_MADS family protein
XP_016466967.1MIKC_MADS family protein
XP_016468661.1MIKC_MADS family protein
XP_016468720.1MIKC_MADS family protein
XP_016470805.1MIKC_MADS family protein
XP_016470806.1MIKC_MADS family protein
XP_016471057.1MIKC_MADS family protein
XP_016471935.1MIKC_MADS family protein
XP_016475006.1MIKC_MADS family protein
XP_016475007.1MIKC_MADS family protein
XP_016475009.1MIKC_MADS family protein
XP_016475412.1MIKC_MADS family protein
XP_016475426.1MIKC_MADS family protein
XP_016475427.1MIKC_MADS family protein
XP_016475428.1MIKC_MADS family protein
XP_016475429.1MIKC_MADS family protein
XP_016476136.1MIKC_MADS family protein
XP_016476137.1MIKC_MADS family protein
XP_016477068.1MIKC_MADS family protein
XP_016477069.1MIKC_MADS family protein
XP_016477070.1MIKC_MADS family protein
XP_016481629.1MIKC_MADS family protein
XP_016481649.1MIKC_MADS family protein
XP_016482057.1MIKC_MADS family protein
XP_016482872.1MIKC_MADS family protein
XP_016483128.1MIKC_MADS family protein
XP_016485764.1MIKC_MADS family protein
XP_016485773.1MIKC_MADS family protein
XP_016486557.1MIKC_MADS family protein
XP_016486565.1MIKC_MADS family protein
XP_016486878.1MIKC_MADS family protein
XP_016489689.1MIKC_MADS family protein
XP_016489895.1MIKC_MADS family protein
XP_016489897.1MIKC_MADS family protein
XP_016490205.1MIKC_MADS family protein
XP_016490845.1MIKC_MADS family protein
XP_016491418.1MIKC_MADS family protein
XP_016491419.1MIKC_MADS family protein
XP_016491420.1MIKC_MADS family protein
XP_016492047.1MIKC_MADS family protein
XP_016492111.1MIKC_MADS family protein
XP_016492112.1MIKC_MADS family protein
XP_016492113.1MIKC_MADS family protein
XP_016492114.1MIKC_MADS family protein
XP_016492115.1MIKC_MADS family protein
XP_016492116.1MIKC_MADS family protein
XP_016492117.1MIKC_MADS family protein
XP_016492118.1MIKC_MADS family protein
XP_016492493.1MIKC_MADS family protein
XP_016492494.1MIKC_MADS family protein
XP_016493539.1MIKC_MADS family protein
XP_016493540.1MIKC_MADS family protein
XP_016494037.1MIKC_MADS family protein
XP_016494038.1MIKC_MADS family protein
XP_016496095.1MIKC_MADS family protein
XP_016497178.1MIKC_MADS family protein
XP_016497179.1MIKC_MADS family protein
XP_016498123.1MIKC_MADS family protein
XP_016498400.1MIKC_MADS family protein
XP_016498401.1MIKC_MADS family protein
XP_016500311.1MIKC_MADS family protein
XP_016500313.1MIKC_MADS family protein
XP_016500314.1MIKC_MADS family protein
XP_016500618.1MIKC_MADS family protein
XP_016501075.1MIKC_MADS family protein
XP_016502910.1MIKC_MADS family protein
XP_016502911.1MIKC_MADS family protein
XP_016502912.1MIKC_MADS family protein
XP_016503027.1MIKC_MADS family protein
XP_016507439.1MIKC_MADS family protein
XP_016507440.1MIKC_MADS family protein
XP_016507611.1MIKC_MADS family protein
XP_016507612.1MIKC_MADS family protein
XP_016507613.1MIKC_MADS family protein
XP_016507614.1MIKC_MADS family protein
XP_016507615.1MIKC_MADS family protein
XP_016507616.1MIKC_MADS family protein
XP_016508650.1MIKC_MADS family protein
XP_016509299.1MIKC_MADS family protein
XP_016511592.1MIKC_MADS family protein
XP_016512460.1MIKC_MADS family protein
XP_016513593.1MIKC_MADS family protein
XP_016513600.1MIKC_MADS family protein
XP_016513605.1MIKC_MADS family protein
XP_016513611.1MIKC_MADS family protein
XP_016513617.1MIKC_MADS family protein
XP_016513626.1MIKC_MADS family protein
XP_016515329.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513