PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
M-type_MADS Family
Species TF ID Description
XP_016432357.1M-type_MADS family protein
XP_016433373.1M-type_MADS family protein
XP_016433393.1M-type_MADS family protein
XP_016435742.1M-type_MADS family protein
XP_016436438.1M-type_MADS family protein
XP_016436509.1M-type_MADS family protein
XP_016436586.1M-type_MADS family protein
XP_016436587.1M-type_MADS family protein
XP_016436652.1M-type_MADS family protein
XP_016436758.1M-type_MADS family protein
XP_016437910.1M-type_MADS family protein
XP_016438828.1M-type_MADS family protein
XP_016438865.1M-type_MADS family protein
XP_016439162.1M-type_MADS family protein
XP_016439170.1M-type_MADS family protein
XP_016439637.1M-type_MADS family protein
XP_016439864.1M-type_MADS family protein
XP_016441587.1M-type_MADS family protein
XP_016441869.1M-type_MADS family protein
XP_016441870.1M-type_MADS family protein
XP_016443217.1M-type_MADS family protein
XP_016445090.1M-type_MADS family protein
XP_016445596.1M-type_MADS family protein
XP_016445672.1M-type_MADS family protein
XP_016446115.1M-type_MADS family protein
XP_016446189.1M-type_MADS family protein
XP_016446375.1M-type_MADS family protein
XP_016446656.1M-type_MADS family protein
XP_016446657.1M-type_MADS family protein
XP_016447355.1M-type_MADS family protein
XP_016448087.1M-type_MADS family protein
XP_016448088.1M-type_MADS family protein
XP_016448153.1M-type_MADS family protein
XP_016448458.1M-type_MADS family protein
XP_016448849.1M-type_MADS family protein
XP_016448851.1M-type_MADS family protein
XP_016449992.1M-type_MADS family protein
XP_016450158.1M-type_MADS family protein
XP_016450745.1M-type_MADS family protein
XP_016450746.1M-type_MADS family protein
XP_016450765.1M-type_MADS family protein
XP_016451226.1M-type_MADS family protein
XP_016451248.1M-type_MADS family protein
XP_016453921.1M-type_MADS family protein
XP_016454543.1M-type_MADS family protein
XP_016454544.1M-type_MADS family protein
XP_016454545.1M-type_MADS family protein
XP_016454637.1M-type_MADS family protein
XP_016455412.1M-type_MADS family protein
XP_016456681.1M-type_MADS family protein
XP_016456682.1M-type_MADS family protein
XP_016456942.1M-type_MADS family protein
XP_016457900.1M-type_MADS family protein
XP_016458072.1M-type_MADS family protein
XP_016459664.1M-type_MADS family protein
XP_016462434.1M-type_MADS family protein
XP_016463356.1M-type_MADS family protein
XP_016463686.1M-type_MADS family protein
XP_016463824.1M-type_MADS family protein
XP_016464483.1M-type_MADS family protein
XP_016464596.1M-type_MADS family protein
XP_016464597.1M-type_MADS family protein
XP_016467435.1M-type_MADS family protein
XP_016467597.1M-type_MADS family protein
XP_016468130.1M-type_MADS family protein
XP_016469068.1M-type_MADS family protein
XP_016469158.1M-type_MADS family protein
XP_016469240.1M-type_MADS family protein
XP_016469680.1M-type_MADS family protein
XP_016470580.1M-type_MADS family protein
XP_016473940.1M-type_MADS family protein
XP_016474013.1M-type_MADS family protein
XP_016474530.1M-type_MADS family protein
XP_016474532.1M-type_MADS family protein
XP_016474587.1M-type_MADS family protein
XP_016475225.1M-type_MADS family protein
XP_016475573.1M-type_MADS family protein
XP_016476272.1M-type_MADS family protein
XP_016477217.1M-type_MADS family protein
XP_016478803.1M-type_MADS family protein
XP_016478804.1M-type_MADS family protein
XP_016478805.1M-type_MADS family protein
XP_016479567.1M-type_MADS family protein
XP_016480271.1M-type_MADS family protein
XP_016482432.1M-type_MADS family protein
XP_016482626.1M-type_MADS family protein
XP_016483969.1M-type_MADS family protein
XP_016484146.1M-type_MADS family protein
XP_016484149.1M-type_MADS family protein
XP_016484155.1M-type_MADS family protein
XP_016484163.1M-type_MADS family protein
XP_016484291.1M-type_MADS family protein
XP_016485321.1M-type_MADS family protein
XP_016485691.1M-type_MADS family protein
XP_016487647.1M-type_MADS family protein
XP_016487648.1M-type_MADS family protein
XP_016487649.1M-type_MADS family protein
XP_016488243.1M-type_MADS family protein
XP_016488614.1M-type_MADS family protein
XP_016488644.1M-type_MADS family protein
XP_016488950.1M-type_MADS family protein
XP_016489113.1M-type_MADS family protein
XP_016489728.1M-type_MADS family protein
XP_016489730.1M-type_MADS family protein
XP_016489731.1M-type_MADS family protein
XP_016491827.1M-type_MADS family protein
XP_016491828.1M-type_MADS family protein
XP_016493006.1M-type_MADS family protein
XP_016493223.1M-type_MADS family protein
XP_016493472.1M-type_MADS family protein
XP_016493747.1M-type_MADS family protein
XP_016494312.1M-type_MADS family protein
XP_016494890.1M-type_MADS family protein
XP_016497146.1M-type_MADS family protein
XP_016497501.1M-type_MADS family protein
XP_016497540.1M-type_MADS family protein
XP_016498681.1M-type_MADS family protein
XP_016499254.1M-type_MADS family protein
XP_016499255.1M-type_MADS family protein
XP_016499257.1M-type_MADS family protein
XP_016499258.1M-type_MADS family protein
XP_016499259.1M-type_MADS family protein
XP_016502248.1M-type_MADS family protein
XP_016502647.1M-type_MADS family protein
XP_016503456.1M-type_MADS family protein
XP_016505217.1M-type_MADS family protein
XP_016505803.1M-type_MADS family protein
XP_016506481.1M-type_MADS family protein
XP_016506589.1M-type_MADS family protein
XP_016506626.1M-type_MADS family protein
XP_016506973.1M-type_MADS family protein
XP_016508949.1M-type_MADS family protein
XP_016508956.1M-type_MADS family protein
XP_016509382.1M-type_MADS family protein
XP_016510944.1M-type_MADS family protein
XP_016511813.1M-type_MADS family protein
XP_016513302.1M-type_MADS family protein
XP_016513472.1M-type_MADS family protein
XP_016513680.1M-type_MADS family protein
XP_016514293.1M-type_MADS family protein
XP_016514332.1M-type_MADS family protein
XP_016514484.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513