PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
HD-ZIP Family
Species TF ID Description
XP_016499039.1HD-ZIP family protein
XP_016509870.1HD-ZIP family protein
XP_016480122.1HD-ZIP family protein
XP_016487233.1HD-ZIP family protein
XP_016465587.1HD-ZIP family protein
XP_016455522.1HD-ZIP family protein
XP_016502437.1HD-ZIP family protein
XP_016481469.1HD-ZIP family protein
XP_016464197.1HD-ZIP family protein
XP_016464196.1HD-ZIP family protein
XP_016486992.1HD-ZIP family protein
XP_016515164.1HD-ZIP family protein
XP_016432971.1HD-ZIP family protein
XP_016468581.1HD-ZIP family protein
XP_016468582.1HD-ZIP family protein
XP_016490251.1HD-ZIP family protein
XP_016490250.1HD-ZIP family protein
XP_016461905.1HD-ZIP family protein
XP_016456347.1HD-ZIP family protein
XP_016456346.1HD-ZIP family protein
XP_016473222.1HD-ZIP family protein
XP_016451121.1HD-ZIP family protein
XP_016500042.1HD-ZIP family protein
XP_016451115.1HD-ZIP family protein
XP_016500773.1HD-ZIP family protein
XP_016483921.1HD-ZIP family protein
XP_016493903.1HD-ZIP family protein
XP_016464969.1HD-ZIP family protein
XP_016464966.1HD-ZIP family protein
XP_016501170.1HD-ZIP family protein
XP_016461626.1HD-ZIP family protein
XP_016500102.1HD-ZIP family protein
XP_016496556.1HD-ZIP family protein
XP_016462220.1HD-ZIP family protein
XP_016486665.1HD-ZIP family protein
XP_016496679.1HD-ZIP family protein
XP_016494558.1HD-ZIP family protein
XP_016442143.1HD-ZIP family protein
XP_016460142.1HD-ZIP family protein
XP_016436508.1HD-ZIP family protein
XP_016459121.1HD-ZIP family protein
XP_016447066.1HD-ZIP family protein
XP_016440107.1HD-ZIP family protein
XP_016459122.1HD-ZIP family protein
XP_016489981.1HD-ZIP family protein
XP_016503886.1HD-ZIP family protein
XP_016504931.1HD-ZIP family protein
XP_016433151.1HD-ZIP family protein
XP_016497876.1HD-ZIP family protein
XP_016508631.1HD-ZIP family protein
XP_016445267.1HD-ZIP family protein
XP_016504930.1HD-ZIP family protein
XP_016490887.1HD-ZIP family protein
XP_016455411.1HD-ZIP family protein
XP_016444539.1HD-ZIP family protein
XP_016474071.1HD-ZIP family protein
XP_016441621.1HD-ZIP family protein
XP_016442723.1HD-ZIP family protein
XP_016490907.1HD-ZIP family protein
XP_016491179.1HD-ZIP family protein
XP_016483184.1HD-ZIP family protein
XP_016480425.1HD-ZIP family protein
XP_016440936.1HD-ZIP family protein
XP_016482786.1HD-ZIP family protein
XP_016451193.1HD-ZIP family protein
XP_016513091.1HD-ZIP family protein
XP_016508958.1HD-ZIP family protein
XP_016491526.1HD-ZIP family protein
XP_016461624.1HD-ZIP family protein
XP_016461625.1HD-ZIP family protein
XP_016452182.1HD-ZIP family protein
XP_016442443.1HD-ZIP family protein
XP_016509639.1HD-ZIP family protein
XP_016444534.1HD-ZIP family protein
XP_016500342.1HD-ZIP family protein
XP_016485761.1HD-ZIP family protein
XP_016479504.1HD-ZIP family protein
XP_016476643.1HD-ZIP family protein
XP_016514208.1HD-ZIP family protein
XP_016447582.1HD-ZIP family protein
XP_016440385.1HD-ZIP family protein
XP_016462654.1HD-ZIP family protein
XP_016462655.1HD-ZIP family protein
XP_016462656.1HD-ZIP family protein
XP_016462657.1HD-ZIP family protein
XP_016479155.1HD-ZIP family protein
XP_016479154.1HD-ZIP family protein
XP_016508926.1HD-ZIP family protein
XP_016508927.1HD-ZIP family protein
XP_016458397.1HD-ZIP family protein
XP_016458398.1HD-ZIP family protein
XP_016458399.1HD-ZIP family protein
XP_016458396.1HD-ZIP family protein
XP_016501674.1HD-ZIP family protein
XP_016486479.1HD-ZIP family protein
XP_016486480.1HD-ZIP family protein
XP_016466997.1HD-ZIP family protein
XP_016466998.1HD-ZIP family protein
XP_016466999.1HD-ZIP family protein
XP_016467000.1HD-ZIP family protein
XP_016467001.1HD-ZIP family protein
XP_016510654.1HD-ZIP family protein
XP_016447957.1HD-ZIP family protein
XP_016490208.1HD-ZIP family protein
XP_016465399.1HD-ZIP family protein
XP_016449923.1HD-ZIP family protein
XP_016441515.1HD-ZIP family protein
XP_016512956.1HD-ZIP family protein
XP_016467380.1HD-ZIP family protein
XP_016459078.1HD-ZIP family protein
XP_016459079.1HD-ZIP family protein
XP_016488110.1HD-ZIP family protein
XP_016434103.1HD-ZIP family protein
XP_016434104.1HD-ZIP family protein
XP_016442710.1HD-ZIP family protein
XP_016445173.1HD-ZIP family protein
XP_016479156.1HD-ZIP family protein
XP_016498616.1HD-ZIP family protein
XP_016468230.1HD-ZIP family protein
XP_016434105.1HD-ZIP family protein
XP_016503308.1HD-ZIP family protein
XP_016503307.1HD-ZIP family protein
XP_016501664.1HD-ZIP family protein
XP_016501663.1HD-ZIP family protein
XP_016451582.1HD-ZIP family protein
XP_016468064.1HD-ZIP family protein
XP_016468065.1HD-ZIP family protein
XP_016468062.1HD-ZIP family protein
XP_016468061.1HD-ZIP family protein
XP_016449095.1HD-ZIP family protein
XP_016496403.1HD-ZIP family protein
XP_016441514.1HD-ZIP family protein
XP_016438836.1HD-ZIP family protein
XP_016457239.1HD-ZIP family protein
XP_016457238.1HD-ZIP family protein
XP_016472209.1HD-ZIP family protein
XP_016494823.1HD-ZIP family protein
XP_016504967.1HD-ZIP family protein
XP_016504968.1HD-ZIP family protein
XP_016494822.1HD-ZIP family protein
XP_016450789.1HD-ZIP family protein
XP_016450790.1HD-ZIP family protein
XP_016450791.1HD-ZIP family protein
XP_016493114.1HD-ZIP family protein
XP_016435660.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401