PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana tabacum
E2F/DP Family
Species TF ID Description
XP_016433353.1E2F/DP family protein
XP_016440715.1E2F/DP family protein
XP_016445600.1E2F/DP family protein
XP_016445601.1E2F/DP family protein
XP_016453463.1E2F/DP family protein
XP_016453464.1E2F/DP family protein
XP_016453465.1E2F/DP family protein
XP_016457927.1E2F/DP family protein
XP_016465902.1E2F/DP family protein
XP_016465903.1E2F/DP family protein
XP_016470703.1E2F/DP family protein
XP_016473683.1E2F/DP family protein
XP_016482505.1E2F/DP family protein
XP_016482506.1E2F/DP family protein
XP_016484172.1E2F/DP family protein
XP_016484236.1E2F/DP family protein
XP_016484298.1E2F/DP family protein
XP_016497357.1E2F/DP family protein
XP_016497987.1E2F/DP family protein
XP_016501039.1E2F/DP family protein
XP_016503156.1E2F/DP family protein
XP_016509350.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710