PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana sylvestris
HD-ZIP Family
Species TF ID Description
XP_009777424.1HD-ZIP family protein
XP_009763971.1HD-ZIP family protein
XP_009777009.1HD-ZIP family protein
XP_009786815.1HD-ZIP family protein
XP_009789655.1HD-ZIP family protein
XP_009783878.1HD-ZIP family protein
XP_009775434.1HD-ZIP family protein
XP_009775433.1HD-ZIP family protein
XP_009775432.1HD-ZIP family protein
XP_009773747.1HD-ZIP family protein
XP_009783877.1HD-ZIP family protein
XP_009798791.1HD-ZIP family protein
XP_009798790.1HD-ZIP family protein
XP_009767401.1HD-ZIP family protein
XP_009768030.1HD-ZIP family protein
XP_009766179.1HD-ZIP family protein
XP_009766178.1HD-ZIP family protein
XP_009766177.1HD-ZIP family protein
XP_009794845.1HD-ZIP family protein
XP_009764264.1HD-ZIP family protein
XP_009800807.1HD-ZIP family protein
XP_009766848.1HD-ZIP family protein
XP_009775231.1HD-ZIP family protein
XP_009792428.1HD-ZIP family protein
XP_009788263.1HD-ZIP family protein
XP_009801495.1HD-ZIP family protein
XP_009782170.1HD-ZIP family protein
XP_009803292.1HD-ZIP family protein
XP_009758049.1HD-ZIP family protein
XP_009775418.1HD-ZIP family protein
XP_009798092.1HD-ZIP family protein
XP_009783420.1HD-ZIP family protein
XP_009796334.1HD-ZIP family protein
XP_009802790.1HD-ZIP family protein
XP_009800499.1HD-ZIP family protein
XP_009767818.1HD-ZIP family protein
XP_009788628.1HD-ZIP family protein
XP_009783627.1HD-ZIP family protein
XP_009778899.1HD-ZIP family protein
XP_009796883.1HD-ZIP family protein
XP_009791458.1HD-ZIP family protein
XP_009802441.1HD-ZIP family protein
XP_009794538.1HD-ZIP family protein
XP_009801498.1HD-ZIP family protein
XP_009790281.1HD-ZIP family protein
XP_009790282.1HD-ZIP family protein
XP_009790283.1HD-ZIP family protein
XP_009790284.1HD-ZIP family protein
XP_009793614.1HD-ZIP family protein
XP_009793615.1HD-ZIP family protein
XP_009793618.1HD-ZIP family protein
XP_009778213.1HD-ZIP family protein
XP_009799795.1HD-ZIP family protein
XP_009799796.1HD-ZIP family protein
XP_009799798.1HD-ZIP family protein
XP_009799799.1HD-ZIP family protein
XP_009799800.1HD-ZIP family protein
XP_009766038.1HD-ZIP family protein
XP_009782444.1HD-ZIP family protein
XP_009782443.1HD-ZIP family protein
XP_009771098.1HD-ZIP family protein
XP_009802527.1HD-ZIP family protein
XP_009802525.1HD-ZIP family protein
XP_009802526.1HD-ZIP family protein
XP_009802524.1HD-ZIP family protein
XP_009781184.1HD-ZIP family protein
XP_009786509.1HD-ZIP family protein
XP_009774805.1HD-ZIP family protein
XP_009777912.1HD-ZIP family protein
XP_009777911.1HD-ZIP family protein
XP_009778533.1HD-ZIP family protein
XP_009774404.1HD-ZIP family protein
XP_009774405.1HD-ZIP family protein
XP_009774406.1HD-ZIP family protein
XP_009774402.1HD-ZIP family protein
XP_009774401.1HD-ZIP family protein
XP_009771835.1HD-ZIP family protein
XP_009771833.1HD-ZIP family protein
XP_009786383.1HD-ZIP family protein
XP_009776589.1HD-ZIP family protein
XP_009786380.1HD-ZIP family protein
XP_009786381.1HD-ZIP family protein
XP_009786382.1HD-ZIP family protein
XP_009771801.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401