PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nelumbo nucifera
HD-ZIP Family
Species TF ID Description
NNU_022850-RAHD-ZIP family protein
NNU_000783-RAHD-ZIP family protein
NNU_017478-RAHD-ZIP family protein
NNU_022888-RAHD-ZIP family protein
NNU_001809-RAHD-ZIP family protein
NNU_023122-RAHD-ZIP family protein
NNU_008754-RAHD-ZIP family protein
NNU_000742-RAHD-ZIP family protein
NNU_019208-RAHD-ZIP family protein
NNU_008009-RAHD-ZIP family protein
NNU_013013-RAHD-ZIP family protein
NNU_025009-RAHD-ZIP family protein
NNU_002711-RAHD-ZIP family protein
NNU_000528-RAHD-ZIP family protein
NNU_021027-RAHD-ZIP family protein
NNU_002328-RAHD-ZIP family protein
NNU_026415-RAHD-ZIP family protein
NNU_006466-RAHD-ZIP family protein
NNU_004414-RAHD-ZIP family protein
NNU_000122-RAHD-ZIP family protein
NNU_004445-RAHD-ZIP family protein
NNU_018143-RAHD-ZIP family protein
NNU_024936-RAHD-ZIP family protein
NNU_024149-RAHD-ZIP family protein
NNU_009675-RAHD-ZIP family protein
NNU_012803-RAHD-ZIP family protein
NNU_018738-RAHD-ZIP family protein
NNU_022939-RAHD-ZIP family protein
NNU_003467-RAHD-ZIP family protein
NNU_019425-RAHD-ZIP family protein
NNU_005933-RAHD-ZIP family protein
NNU_014296-RAHD-ZIP family protein
NNU_006794-RAHD-ZIP family protein
NNU_013977-RAHD-ZIP family protein
NNU_014660-RAHD-ZIP family protein
NNU_026148-RAHD-ZIP family protein
NNU_003392-RAHD-ZIP family protein
NNU_020098-RAHD-ZIP family protein
NNU_000302-RAHD-ZIP family protein
NNU_024685-RAHD-ZIP family protein
NNU_021212-RAHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401