PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana benthamiana
bHLH Family
Species TF ID Description
Niben101Ctg12776g00001.1bHLH family protein
Niben101Ctg15076g00003.1bHLH family protein
Niben101Ctg15612g00002.1bHLH family protein
Niben101Scf00010g05014.1bHLH family protein
Niben101Scf00024g00012.1bHLH family protein
Niben101Scf00047g03012.1bHLH family protein
Niben101Scf00063g01019.1bHLH family protein
Niben101Scf00067g02010.1bHLH family protein
Niben101Scf00069g03001.1bHLH family protein
Niben101Scf00069g08002.1bHLH family protein
Niben101Scf00129g00001.1bHLH family protein
Niben101Scf00153g00020.1bHLH family protein
Niben101Scf00176g00013.1bHLH family protein
Niben101Scf00176g06015.1bHLH family protein
Niben101Scf00182g00001.1bHLH family protein
Niben101Scf00187g02027.1bHLH family protein
Niben101Scf00220g02002.1bHLH family protein
Niben101Scf00228g11012.1bHLH family protein
Niben101Scf00253g01016.1bHLH family protein
Niben101Scf00270g13010.1bHLH family protein
Niben101Scf00276g00010.1bHLH family protein
Niben101Scf00314g02004.1bHLH family protein
Niben101Scf00339g10010.1bHLH family protein
Niben101Scf00351g02003.1bHLH family protein
Niben101Scf00376g01004.1bHLH family protein
Niben101Scf00378g03005.1bHLH family protein
Niben101Scf00383g03006.1bHLH family protein
Niben101Scf00415g00003.1bHLH family protein
Niben101Scf00415g03019.1bHLH family protein
Niben101Scf00419g00023.1bHLH family protein
Niben101Scf00439g04009.1bHLH family protein
Niben101Scf00446g05004.1bHLH family protein
Niben101Scf00530g06018.1bHLH family protein
Niben101Scf00565g00012.1bHLH family protein
Niben101Scf00578g04002.1bHLH family protein
Niben101Scf00590g00007.1bHLH family protein
Niben101Scf00592g00026.1bHLH family protein
Niben101Scf00603g01001.1bHLH family protein
Niben101Scf00639g02005.1bHLH family protein
Niben101Scf00662g05006.1bHLH family protein
Niben101Scf00690g03007.1bHLH family protein
Niben101Scf00691g03015.1bHLH family protein
Niben101Scf00698g02020.1bHLH family protein
Niben101Scf00765g00008.1bHLH family protein
Niben101Scf00821g08003.1bHLH family protein
Niben101Scf00868g07004.1bHLH family protein
Niben101Scf00883g13017.1bHLH family protein
Niben101Scf00893g00004.1bHLH family protein
Niben101Scf00961g01024.1bHLH family protein
Niben101Scf00985g04006.1bHLH family protein
Niben101Scf01006g00001.1bHLH family protein
Niben101Scf01102g05005.1bHLH family protein
Niben101Scf01102g05008.1bHLH family protein
Niben101Scf01139g03005.1bHLH family protein
Niben101Scf01141g00004.1bHLH family protein
Niben101Scf01146g01002.1bHLH family protein
Niben101Scf01147g05011.1bHLH family protein
Niben101Scf01171g08002.1bHLH family protein
Niben101Scf01182g03011.1bHLH family protein
Niben101Scf01200g04003.1bHLH family protein
Niben101Scf01249g02006.1bHLH family protein
Niben101Scf01253g00005.1bHLH family protein
Niben101Scf01255g00001.1bHLH family protein
Niben101Scf01316g05002.1bHLH family protein
Niben101Scf01326g06002.1bHLH family protein
Niben101Scf01350g04013.1bHLH family protein
Niben101Scf01362g02001.1bHLH family protein
Niben101Scf01396g05005.1bHLH family protein
Niben101Scf01411g00012.1bHLH family protein
Niben101Scf01518g00011.1bHLH family protein
Niben101Scf01577g01014.1bHLH family protein
Niben101Scf01585g01002.1bHLH family protein
Niben101Scf01627g03009.1bHLH family protein
Niben101Scf01687g12007.1bHLH family protein
Niben101Scf01700g02004.1bHLH family protein
Niben101Scf01700g03017.1bHLH family protein
Niben101Scf01710g04007.1bHLH family protein
Niben101Scf01717g01007.1bHLH family protein
Niben101Scf01727g05001.1bHLH family protein
Niben101Scf01782g11003.1bHLH family protein
Niben101Scf01785g10012.1bHLH family protein
Niben101Scf01802g02017.1bHLH family protein
Niben101Scf01847g02005.1bHLH family protein
Niben101Scf01903g02006.1bHLH family protein
Niben101Scf01954g02004.1bHLH family protein
Niben101Scf01983g12001.1bHLH family protein
Niben101Scf02004g00019.1bHLH family protein
Niben101Scf02063g03016.1bHLH family protein
Niben101Scf02073g03007.1bHLH family protein
Niben101Scf02073g03008.1bHLH family protein
Niben101Scf02172g04005.1bHLH family protein
Niben101Scf02216g02019.1bHLH family protein
Niben101Scf02239g02007.1bHLH family protein
Niben101Scf02262g02007.1bHLH family protein
Niben101Scf02287g00010.1bHLH family protein
Niben101Scf02289g02009.1bHLH family protein
Niben101Scf02398g00005.1bHLH family protein
Niben101Scf02417g07006.1bHLH family protein
Niben101Scf02417g08001.1bHLH family protein
Niben101Scf02420g07005.1bHLH family protein
Niben101Scf02420g08014.1bHLH family protein
Niben101Scf02440g00004.1bHLH family protein
Niben101Scf02459g08001.1bHLH family protein
Niben101Scf02459g08005.1bHLH family protein
Niben101Scf02509g12006.1bHLH family protein
Niben101Scf02511g04004.1bHLH family protein
Niben101Scf02631g04003.1bHLH family protein
Niben101Scf02681g01005.1bHLH family protein
Niben101Scf02752g10010.1bHLH family protein
Niben101Scf02756g00013.1bHLH family protein
Niben101Scf02757g03009.1bHLH family protein
Niben101Scf02761g01001.1bHLH family protein
Niben101Scf02821g14003.1bHLH family protein
Niben101Scf02821g14006.1bHLH family protein
Niben101Scf02844g03014.1bHLH family protein
Niben101Scf02881g00009.1bHLH family protein
Niben101Scf02915g04003.1bHLH family protein
Niben101Scf02955g01007.1bHLH family protein
Niben101Scf02955g02004.1bHLH family protein
Niben101Scf03000g02009.1bHLH family protein
Niben101Scf03006g10002.1bHLH family protein
Niben101Scf03006g10013.1bHLH family protein
Niben101Scf03047g01004.1bHLH family protein
Niben101Scf03068g04001.1bHLH family protein
Niben101Scf03145g01007.1bHLH family protein
Niben101Scf03191g01013.1bHLH family protein
Niben101Scf03202g09007.1bHLH family protein
Niben101Scf03208g07011.1bHLH family protein
Niben101Scf03309g07006.1bHLH family protein
Niben101Scf03419g01009.1bHLH family protein
Niben101Scf03422g02007.1bHLH family protein
Niben101Scf03455g01009.1bHLH family protein
Niben101Scf03551g01010.1bHLH family protein
Niben101Scf03564g00018.1bHLH family protein
Niben101Scf03577g01023.1bHLH family protein
Niben101Scf03596g00009.1bHLH family protein
Niben101Scf03628g12006.1bHLH family protein
Niben101Scf03670g02006.1bHLH family protein
Niben101Scf03824g02004.1bHLH family protein
Niben101Scf03882g01003.1bHLH family protein
Niben101Scf03894g04001.1bHLH family protein
Niben101Scf03934g05002.1bHLH family protein
Niben101Scf04003g05003.1bHLH family protein
Niben101Scf04007g05007.1bHLH family protein
Niben101Scf04167g02003.1bHLH family protein
Niben101Scf04187g00028.1bHLH family protein
Niben101Scf04206g02010.1bHLH family protein
Niben101Scf04285g03018.1bHLH family protein
Niben101Scf04287g02001.1bHLH family protein
Niben101Scf04290g00010.1bHLH family protein
Niben101Scf04316g02003.1bHLH family protein
Niben101Scf04339g00001.1bHLH family protein
Niben101Scf04386g08002.1bHLH family protein
Niben101Scf04455g01003.1bHLH family protein
Niben101Scf04657g03011.1bHLH family protein
Niben101Scf04657g05006.1bHLH family protein
Niben101Scf04657g06001.1bHLH family protein
Niben101Scf04686g02002.1bHLH family protein
Niben101Scf04690g02006.1bHLH family protein
Niben101Scf04941g01010.1bHLH family protein
Niben101Scf04950g03011.1bHLH family protein
Niben101Scf04967g00009.1bHLH family protein
Niben101Scf04991g00003.1bHLH family protein
Niben101Scf04995g00002.1bHLH family protein
Niben101Scf04995g05002.1bHLH family protein
Niben101Scf05073g02002.1bHLH family protein
Niben101Scf05115g03006.1bHLH family protein
Niben101Scf05175g02005.1bHLH family protein
Niben101Scf05203g01001.1bHLH family protein
Niben101Scf05203g03015.1bHLH family protein
Niben101Scf05371g00004.1bHLH family protein
Niben101Scf05413g05003.1bHLH family protein
Niben101Scf05417g03024.1bHLH family protein
Niben101Scf05483g00007.1bHLH family protein
Niben101Scf05487g01017.1bHLH family protein
Niben101Scf05549g02006.1bHLH family protein
Niben101Scf05713g03006.1bHLH family protein
Niben101Scf05713g04012.1bHLH family protein
Niben101Scf05717g00005.1bHLH family protein
Niben101Scf05912g01009.1bHLH family protein
Niben101Scf05923g05004.1bHLH family protein
Niben101Scf06009g00028.1bHLH family protein
Niben101Scf06030g00002.1bHLH family protein
Niben101Scf06113g00017.1bHLH family protein
Niben101Scf06172g04004.1bHLH family protein
Niben101Scf06248g01003.1bHLH family protein
Niben101Scf06261g01001.1bHLH family protein
Niben101Scf06286g03008.1bHLH family protein
Niben101Scf06376g01011.1bHLH family protein
Niben101Scf06388g04001.1bHLH family protein
Niben101Scf06514g02019.1bHLH family protein
Niben101Scf06518g02008.1bHLH family protein
Niben101Scf06525g00011.1bHLH family protein
Niben101Scf06589g00008.1bHLH family protein
Niben101Scf06618g00004.1bHLH family protein
Niben101Scf06621g02010.1bHLH family protein
Niben101Scf06623g00012.1bHLH family protein
Niben101Scf06674g05010.1bHLH family protein
Niben101Scf06822g04004.1bHLH family protein
Niben101Scf06850g00011.1bHLH family protein
Niben101Scf06860g00001.1bHLH family protein
Niben101Scf06872g01004.1bHLH family protein
Niben101Scf06872g02002.1bHLH family protein
Niben101Scf06886g01011.1bHLH family protein
Niben101Scf06896g02005.1bHLH family protein
Niben101Scf06939g05008.1bHLH family protein
Niben101Scf07030g08005.1bHLH family protein
Niben101Scf07073g04002.1bHLH family protein
Niben101Scf07278g02005.1bHLH family protein
Niben101Scf07322g00013.1bHLH family protein
Niben101Scf07365g00017.1bHLH family protein
Niben101Scf07437g04013.1bHLH family protein
Niben101Scf07593g03015.1bHLH family protein
Niben101Scf07765g01011.1bHLH family protein
Niben101Scf07829g04011.1bHLH family protein
Niben101Scf07919g00002.1bHLH family protein
Niben101Scf08001g02016.1bHLH family protein
Niben101Scf08006g01028.1bHLH family protein
Niben101Scf08127g01015.1bHLH family protein
Niben101Scf08127g05002.1bHLH family protein
Niben101Scf08298g03010.1bHLH family protein
Niben101Scf08333g00001.1bHLH family protein
Niben101Scf08333g05001.1bHLH family protein
Niben101Scf08350g00003.1bHLH family protein
Niben101Scf08351g04015.1bHLH family protein
Niben101Scf08394g00001.1bHLH family protein
Niben101Scf08447g03007.1bHLH family protein
Niben101Scf08470g06001.1bHLH family protein
Niben101Scf08573g00005.1bHLH family protein
Niben101Scf08672g02003.1bHLH family protein
Niben101Scf08972g02007.1bHLH family protein
Niben101Scf09353g03003.1bHLH family protein
Niben101Scf09368g02010.1bHLH family protein
Niben101Scf09663g00002.1bHLH family protein
Niben101Scf09861g01009.1bHLH family protein
Niben101Scf10031g02004.1bHLH family protein
Niben101Scf10073g00013.1bHLH family protein
Niben101Scf10241g00004.1bHLH family protein
Niben101Scf10566g01003.1bHLH family protein
Niben101Scf10974g01004.1bHLH family protein
Niben101Scf11491g01004.1bHLH family protein
Niben101Scf11531g00002.1bHLH family protein
Niben101Scf11805g02005.1bHLH family protein
Niben101Scf11853g00001.1bHLH family protein
Niben101Scf11884g00019.1bHLH family protein
Niben101Scf12132g00007.1bHLH family protein
Niben101Scf12293g01002.1bHLH family protein
Niben101Scf12852g03016.1bHLH family protein
Niben101Scf13099g00014.1bHLH family protein
Niben101Scf13842g01008.1bHLH family protein
Niben101Scf13886g01021.1bHLH family protein
Niben101Scf13942g00027.1bHLH family protein
Niben101Scf14118g00010.1bHLH family protein
Niben101Scf14179g00003.1bHLH family protein
Niben101Scf14344g00004.1bHLH family protein
Niben101Scf14606g00002.1bHLH family protein
Niben101Scf14843g01001.1bHLH family protein
Niben101Scf15224g00002.1bHLH family protein
Niben101Scf15993g00012.1bHLH family protein
Niben101Scf15993g00013.1bHLH family protein
Niben101Scf16585g02001.1bHLH family protein
Niben101Scf16706g01002.1bHLH family protein
Niben101Scf16888g00007.1bHLH family protein
Niben101Scf16981g02005.1bHLH family protein
Niben101Scf18066g00001.1bHLH family protein
Niben101Scf18418g03002.1bHLH family protein
Niben101Scf18898g00012.1bHLH family protein
Niben101Scf19439g00001.1bHLH family protein
Niben101Scf22360g00006.1bHLH family protein
Niben101Scf23305g01001.1bHLH family protein
Niben101Scf24249g00001.1bHLH family protein
Niben101Scf27908g01002.1bHLH family protein
Niben101Scf32603g00010.1bHLH family protein
Niben101Scf32858g00002.1bHLH family protein
Niben101Scf34081g00018.1bHLH family protein
Niben101Scf34542g00003.1bHLH family protein
Niben101Scf37335g00005.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250