PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana benthamiana
ZF-HD Family
Species TF ID Description
Niben101Ctg03622g00002.1ZF-HD family protein
Niben101Ctg14738g00001.1ZF-HD family protein
Niben101Ctg15574g00001.1ZF-HD family protein
Niben101Scf00021g01016.1ZF-HD family protein
Niben101Scf00063g14011.1ZF-HD family protein
Niben101Scf00305g00001.1ZF-HD family protein
Niben101Scf00350g04011.1ZF-HD family protein
Niben101Scf00472g01008.1ZF-HD family protein
Niben101Scf00472g02003.1ZF-HD family protein
Niben101Scf00705g05011.1ZF-HD family protein
Niben101Scf00966g01008.1ZF-HD family protein
Niben101Scf01326g02001.1ZF-HD family protein
Niben101Scf01326g02002.1ZF-HD family protein
Niben101Scf01372g06020.1ZF-HD family protein
Niben101Scf01970g06006.1ZF-HD family protein
Niben101Scf01970g06008.1ZF-HD family protein
Niben101Scf01970g06013.1ZF-HD family protein
Niben101Scf03236g00004.1ZF-HD family protein
Niben101Scf03236g00006.1ZF-HD family protein
Niben101Scf03421g05004.1ZF-HD family protein
Niben101Scf03474g01001.1ZF-HD family protein
Niben101Scf03660g01004.1ZF-HD family protein
Niben101Scf04054g01005.1ZF-HD family protein
Niben101Scf04113g16001.1ZF-HD family protein
Niben101Scf04364g01009.1ZF-HD family protein
Niben101Scf04950g05002.1ZF-HD family protein
Niben101Scf05060g03004.1ZF-HD family protein
Niben101Scf05060g03005.1ZF-HD family protein
Niben101Scf05565g02022.1ZF-HD family protein
Niben101Scf07742g02012.1ZF-HD family protein
Niben101Scf09271g00001.1ZF-HD family protein
Niben101Scf12143g00007.1ZF-HD family protein
Niben101Scf20961g00008.1ZF-HD family protein
Niben101Scf39169g00001.1ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511