PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Nicotiana benthamiana
M-type_MADS Family
Species TF ID Description
Niben101Ctg13673g00002.1M-type_MADS family protein
Niben101Ctg15399g00001.1M-type_MADS family protein
Niben101Scf00063g10005.1M-type_MADS family protein
Niben101Scf00069g12019.1M-type_MADS family protein
Niben101Scf00414g05014.1M-type_MADS family protein
Niben101Scf00472g02011.1M-type_MADS family protein
Niben101Scf00508g10011.1M-type_MADS family protein
Niben101Scf00589g02008.1M-type_MADS family protein
Niben101Scf00627g00003.1M-type_MADS family protein
Niben101Scf00837g03003.1M-type_MADS family protein
Niben101Scf00953g03002.1M-type_MADS family protein
Niben101Scf00953g04018.1M-type_MADS family protein
Niben101Scf00953g04019.1M-type_MADS family protein
Niben101Scf01020g03001.1M-type_MADS family protein
Niben101Scf01124g07001.1M-type_MADS family protein
Niben101Scf01252g01009.1M-type_MADS family protein
Niben101Scf01310g04008.1M-type_MADS family protein
Niben101Scf01310g04011.1M-type_MADS family protein
Niben101Scf01327g01022.1M-type_MADS family protein
Niben101Scf01478g07007.1M-type_MADS family protein
Niben101Scf01711g01003.1M-type_MADS family protein
Niben101Scf01848g02010.1M-type_MADS family protein
Niben101Scf01970g07019.1M-type_MADS family protein
Niben101Scf02060g00010.1M-type_MADS family protein
Niben101Scf02108g02015.1M-type_MADS family protein
Niben101Scf02151g01003.1M-type_MADS family protein
Niben101Scf02151g01004.1M-type_MADS family protein
Niben101Scf02289g05016.1M-type_MADS family protein
Niben101Scf02348g12005.1M-type_MADS family protein
Niben101Scf02543g01002.1M-type_MADS family protein
Niben101Scf02566g02010.1M-type_MADS family protein
Niben101Scf02606g05030.1M-type_MADS family protein
Niben101Scf02740g07006.1M-type_MADS family protein
Niben101Scf02909g03006.1M-type_MADS family protein
Niben101Scf03026g01010.1M-type_MADS family protein
Niben101Scf03048g05006.1M-type_MADS family protein
Niben101Scf03171g01002.1M-type_MADS family protein
Niben101Scf03243g00004.1M-type_MADS family protein
Niben101Scf03488g12001.1M-type_MADS family protein
Niben101Scf03595g01005.1M-type_MADS family protein
Niben101Scf03670g00003.1M-type_MADS family protein
Niben101Scf03671g03023.1M-type_MADS family protein
Niben101Scf04021g02002.1M-type_MADS family protein
Niben101Scf04042g00013.1M-type_MADS family protein
Niben101Scf04053g00001.1M-type_MADS family protein
Niben101Scf04053g00007.1M-type_MADS family protein
Niben101Scf04053g03020.1M-type_MADS family protein
Niben101Scf04074g00008.1M-type_MADS family protein
Niben101Scf04197g01014.1M-type_MADS family protein
Niben101Scf04234g00003.1M-type_MADS family protein
Niben101Scf04396g04001.1M-type_MADS family protein
Niben101Scf04614g07007.1M-type_MADS family protein
Niben101Scf04684g02004.1M-type_MADS family protein
Niben101Scf04690g02040.1M-type_MADS family protein
Niben101Scf04790g01013.1M-type_MADS family protein
Niben101Scf04921g01007.1M-type_MADS family protein
Niben101Scf04934g00005.1M-type_MADS family protein
Niben101Scf04995g09003.1M-type_MADS family protein
Niben101Scf05102g08002.1M-type_MADS family protein
Niben101Scf05483g07003.1M-type_MADS family protein
Niben101Scf05552g06002.1M-type_MADS family protein
Niben101Scf05618g05010.1M-type_MADS family protein
Niben101Scf05620g02002.1M-type_MADS family protein
Niben101Scf05824g08001.1M-type_MADS family protein
Niben101Scf05830g01017.1M-type_MADS family protein
Niben101Scf05962g00001.1M-type_MADS family protein
Niben101Scf05962g00002.1M-type_MADS family protein
Niben101Scf06076g00010.1M-type_MADS family protein
Niben101Scf06094g00010.1M-type_MADS family protein
Niben101Scf06156g01002.1M-type_MADS family protein
Niben101Scf06156g04011.1M-type_MADS family protein
Niben101Scf06517g00007.1M-type_MADS family protein
Niben101Scf06551g00018.1M-type_MADS family protein
Niben101Scf06863g01001.1M-type_MADS family protein
Niben101Scf07034g05008.1M-type_MADS family protein
Niben101Scf07073g00001.1M-type_MADS family protein
Niben101Scf07207g00002.1M-type_MADS family protein
Niben101Scf07207g00003.1M-type_MADS family protein
Niben101Scf07242g05005.1M-type_MADS family protein
Niben101Scf07242g05006.1M-type_MADS family protein
Niben101Scf07508g01008.1M-type_MADS family protein
Niben101Scf07648g01024.1M-type_MADS family protein
Niben101Scf07678g02010.1M-type_MADS family protein
Niben101Scf08039g00019.1M-type_MADS family protein
Niben101Scf08143g03018.1M-type_MADS family protein
Niben101Scf08572g00002.1M-type_MADS family protein
Niben101Scf09234g01005.1M-type_MADS family protein
Niben101Scf09512g04021.1M-type_MADS family protein
Niben101Scf09778g00003.1M-type_MADS family protein
Niben101Scf10287g01013.1M-type_MADS family protein
Niben101Scf13505g02008.1M-type_MADS family protein
Niben101Scf18356g00007.1M-type_MADS family protein
Niben101Scf20949g00001.1M-type_MADS family protein
Niben101Scf27304g00001.1M-type_MADS family protein
Niben101Scf28369g01003.1M-type_MADS family protein
Niben101Scf37475g00001.1M-type_MADS family protein
Niben101Scf37484g00001.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513