PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Nicotiana benthamiana
HD-ZIP Family
Species TF ID Description
Niben101Scf24758g01002.1HD-ZIP family protein
Niben101Scf09157g00010.1HD-ZIP family protein
Niben101Scf02990g09005.1HD-ZIP family protein
Niben101Scf03870g01016.1HD-ZIP family protein
Niben101Scf22883g00002.1HD-ZIP family protein
Niben101Scf00189g05003.1HD-ZIP family protein
Niben101Scf06968g00020.1HD-ZIP family protein
Niben101Scf06286g01010.1HD-ZIP family protein
Niben101Scf03021g03026.1HD-ZIP family protein
Niben101Scf01727g03004.1HD-ZIP family protein
Niben101Scf01500g01020.1HD-ZIP family protein
Niben101Scf03398g06007.1HD-ZIP family protein
Niben101Scf15286g00034.1HD-ZIP family protein
Niben101Scf04407g02024.1HD-ZIP family protein
Niben101Scf12874g00009.1HD-ZIP family protein
Niben101Scf01362g03006.1HD-ZIP family protein
Niben101Scf02279g08003.1HD-ZIP family protein
Niben101Scf06923g00002.1HD-ZIP family protein
Niben101Scf05543g01003.1HD-ZIP family protein
Niben101Scf05855g03003.1HD-ZIP family protein
Niben101Scf00474g11008.1HD-ZIP family protein
Niben101Scf30092g00006.1HD-ZIP family protein
Niben101Scf02439g00023.1HD-ZIP family protein
Niben101Scf00425g03034.1HD-ZIP family protein
Niben101Scf02537g21009.1HD-ZIP family protein
Niben101Scf02858g02013.1HD-ZIP family protein
Niben101Scf02793g13016.1HD-ZIP family protein
Niben101Scf05886g00005.1HD-ZIP family protein
Niben101Scf09075g02003.1HD-ZIP family protein
Niben101Scf17122g00007.1HD-ZIP family protein
Niben101Scf09456g00019.1HD-ZIP family protein
Niben101Scf01326g07001.1HD-ZIP family protein
Niben101Scf00272g11024.1HD-ZIP family protein
Niben101Scf10482g01024.1HD-ZIP family protein
Niben101Scf03693g10004.1HD-ZIP family protein
Niben101Scf03072g00004.1HD-ZIP family protein
Niben101Scf09564g00009.1HD-ZIP family protein
Niben101Scf14805g02006.1HD-ZIP family protein
Niben101Scf04240g02010.1HD-ZIP family protein
Niben101Scf02375g06002.1HD-ZIP family protein
Niben101Scf07121g05012.1HD-ZIP family protein
Niben101Scf08473g00002.1HD-ZIP family protein
Niben101Scf02823g01002.1HD-ZIP family protein
Niben101Scf01524g00017.1HD-ZIP family protein
Niben101Scf01953g01012.1HD-ZIP family protein
Niben101Scf00830g03001.1HD-ZIP family protein
Niben101Scf07393g00006.1HD-ZIP family protein
Niben101Scf03169g06008.1HD-ZIP family protein
Niben101Scf02366g04011.1HD-ZIP family protein
Niben101Scf01222g01012.1HD-ZIP family protein
Niben101Scf02563g01008.1HD-ZIP family protein
Niben101Scf00479g03014.1HD-ZIP family protein
Niben101Scf08871g01002.1HD-ZIP family protein
Niben101Scf03894g03006.1HD-ZIP family protein
Niben101Scf02730g01028.1HD-ZIP family protein
Niben101Scf01521g16002.1HD-ZIP family protein
Niben101Scf02287g01001.1HD-ZIP family protein
Niben101Scf06172g03008.1HD-ZIP family protein
Niben101Scf00626g02003.1HD-ZIP family protein
Niben101Scf07790g01007.1HD-ZIP family protein
Niben101Scf00703g00003.1HD-ZIP family protein
Niben101Scf01374g00003.1HD-ZIP family protein
Niben101Scf02541g02001.1HD-ZIP family protein
Niben101Scf00176g11005.1HD-ZIP family protein
Niben101Scf09847g00006.1HD-ZIP family protein
Niben101Scf04372g00012.1HD-ZIP family protein
Niben101Scf01158g03010.1HD-ZIP family protein
Niben101Scf00013g01005.1HD-ZIP family protein
Niben101Scf01611g00004.1HD-ZIP family protein
Niben101Scf02108g00002.1HD-ZIP family protein
Niben101Scf08693g00002.1HD-ZIP family protein
Niben101Scf01571g03004.1HD-ZIP family protein
Niben101Scf05146g05002.1HD-ZIP family protein
Niben101Scf08137g05001.1HD-ZIP family protein
Niben101Scf01374g07001.1HD-ZIP family protein
Niben101Scf07663g04003.1HD-ZIP family protein
Niben101Scf05919g01007.1HD-ZIP family protein
Niben101Scf04096g09005.1HD-ZIP family protein
Niben101Scf05034g04004.1HD-ZIP family protein
Niben101Scf04220g00002.1HD-ZIP family protein
Niben101Scf00679g07004.1HD-ZIP family protein
Niben101Scf02436g03009.1HD-ZIP family protein
Niben101Scf05988g07003.1HD-ZIP family protein
Niben101Scf07851g02001.1HD-ZIP family protein
Niben101Scf01759g04007.1HD-ZIP family protein
Niben101Scf01926g01007.1HD-ZIP family protein
Niben101Scf00978g00001.1HD-ZIP family protein
Niben101Scf02395g04006.1HD-ZIP family protein
Niben101Scf05105g00001.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401