PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Medicago truncatula
FAR1 Family
Species TF ID Description
Medtr0060s0090.1FAR1 family protein
Medtr0137s0040.1FAR1 family protein
Medtr0402s0040.1FAR1 family protein
Medtr0558s0020.1FAR1 family protein
Medtr0604s0020.1FAR1 family protein
Medtr0853s0010.1FAR1 family protein
Medtr0856s0010.1FAR1 family protein
Medtr1281s0010.1FAR1 family protein
Medtr1g008290.1FAR1 family protein
Medtr1g012760.1FAR1 family protein
Medtr1g012760.2FAR1 family protein
Medtr1g013060.1FAR1 family protein
Medtr1g019850.1FAR1 family protein
Medtr1g050985.1FAR1 family protein
Medtr1g052260.1FAR1 family protein
Medtr1g055240.1FAR1 family protein
Medtr1g057920.1FAR1 family protein
Medtr1g059880.1FAR1 family protein
Medtr1g070355.1FAR1 family protein
Medtr1g083640.1FAR1 family protein
Medtr1g091013.1FAR1 family protein
Medtr1g099140.1FAR1 family protein
Medtr2g014100.1FAR1 family protein
Medtr2g039370.1FAR1 family protein
Medtr2g070590.1FAR1 family protein
Medtr2g090505.1FAR1 family protein
Medtr2g098880.1FAR1 family protein
Medtr2g098880.2FAR1 family protein
Medtr2g098880.3FAR1 family protein
Medtr2g098880.4FAR1 family protein
Medtr2g098880.5FAR1 family protein
Medtr2g098920.1FAR1 family protein
Medtr2g099430.1FAR1 family protein
Medtr2g101460.1FAR1 family protein
Medtr2g101460.2FAR1 family protein
Medtr3g005220.1FAR1 family protein
Medtr3g006370.1FAR1 family protein
Medtr3g006370.2FAR1 family protein
Medtr3g008240.1FAR1 family protein
Medtr3g015530.1FAR1 family protein
Medtr3g030230.1FAR1 family protein
Medtr3g067290.1FAR1 family protein
Medtr3g072200.1FAR1 family protein
Medtr3g077875.1FAR1 family protein
Medtr3g087440.1FAR1 family protein
Medtr3g116710.1FAR1 family protein
Medtr3g448650.1FAR1 family protein
Medtr3g450850.1FAR1 family protein
Medtr3g465760.1FAR1 family protein
Medtr4g035820.1FAR1 family protein
Medtr4g040430.1FAR1 family protein
Medtr4g049670.1FAR1 family protein
Medtr4g057975.1FAR1 family protein
Medtr4g067290.1FAR1 family protein
Medtr4g067290.2FAR1 family protein
Medtr4g067290.3FAR1 family protein
Medtr4g067290.4FAR1 family protein
Medtr4g067290.5FAR1 family protein
Medtr4g067290.6FAR1 family protein
Medtr4g067290.7FAR1 family protein
Medtr4g067290.8FAR1 family protein
Medtr4g080290.1FAR1 family protein
Medtr4g102720.1FAR1 family protein
Medtr4g119600.1FAR1 family protein
Medtr5g015480.1FAR1 family protein
Medtr5g031650.1FAR1 family protein
Medtr5g032260.1FAR1 family protein
Medtr5g039760.1FAR1 family protein
Medtr5g070810.1FAR1 family protein
Medtr5g071590.1FAR1 family protein
Medtr5g076070.1FAR1 family protein
Medtr5g079560.1FAR1 family protein
Medtr6g017200.1FAR1 family protein
Medtr6g022080.1FAR1 family protein
Medtr6g051425.1FAR1 family protein
Medtr6g053140.1FAR1 family protein
Medtr6g060410.1FAR1 family protein
Medtr6g075990.1FAR1 family protein
Medtr6g090505.1FAR1 family protein
Medtr7g028855.1FAR1 family protein
Medtr7g031620.1FAR1 family protein
Medtr7g050385.1FAR1 family protein
Medtr7g060350.1FAR1 family protein
Medtr7g061980.1FAR1 family protein
Medtr7g074790.1FAR1 family protein
Medtr7g113010.1FAR1 family protein
Medtr7g446520.1FAR1 family protein
Medtr8g009330.1FAR1 family protein
Medtr8g035530.1FAR1 family protein
Medtr8g038805.1FAR1 family protein
Medtr8g467420.1FAR1 family protein
FAR1 Family Introduction

We show that Arabidopsis FHY3 and FAR1, which encode two proteins related to Mutator-like transposases, act together to modulate phyA signaling by directly activating the transcription of FHY1 and FHL, whose products are essential for light-induced phyA nuclear accumulation and subsequent light responses. FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conserved in Mutator-like transposases. Further, expression of FHY3 and FAR1 is negatively regulated by phyA signaling. We propose that FHY3 and FAR1 represent transcription factors that have been co-opted from an ancient Mutator-like transposase(s) to modulate phyA-signaling homeostasis in higher plants.

We next used a yeast one-hybrid assay to delineate the DNA sequences to which FHY3 and FAR1 bind. GAD-FHY3 or GAD-FAR1 fusion proteins (GAD, GAL4 transcriptional activation domain), but not GAD alone, activated the LacZ reporter genes driven by the FHY1 and FHL promoters. Deletion analysis narrowed down the FHY3/FAR1 binding site to a 39-bp promoter subfragment located on the "a" fragment for both FHY1 and FHL. Notably, these subfragments share a stretch of consensus sequence, 5'-TTCACGCGCC-3'. Mutating the core sequence "CACGCGC" of this motif (m2 and m3 for FHY1, m5 for FHL) abolished the reporter gene activation by both GAD-FHY3 and GAD-FAR1. Mutating the flanking sequences (m1 and m4) did not obviously affect the reporter gene activation by GAD-FAR1, but clearly reduced activation by GAD-FHY3. Thus, "CACGCGC" likely defines a cis-element that confers specific binding for FHY3 and FAR1 and is named FBS for FHY3-FAR1 binding site.

Lin R, Ding L, Casola C, Ripoll DR, Feschotte C, Wang H.
Transposase-derived transcription factors regulate light signaling in Arabidopsis.
Science, 2007. 318(5854): p. 1302-5.
PMID: 18033885