PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Medicago truncatula
EIL Family
Species TF ID Description
Medtr1g015990.1EIL family protein
Medtr1g024420.1EIL family protein
Medtr2g098450.1EIL family protein
Medtr2g098470.1EIL family protein
Medtr3g010785.1EIL family protein
Medtr3g010790.1EIL family protein
Medtr3g078770.1EIL family protein
Medtr3g087530.1EIL family protein
Medtr5g087790.1EIL family protein
Medtr6g060600.1EIL family protein
Medtr6g460640.1EIL family protein
Medtr7g095580.1EIL family protein
Medtr8g091370.1EIL family protein
EIL Family Introduction

The gaseous phytohormone ethylene regulates various processes related to growth, development, and stress response of higher plants. A largely linear pathway of ethylene signaling was revealed by a number of molecular genetic studies. In the pathway, Ethylene-insensitive3 (EIN3) and EIN3-like (EIL) proteins are the key transcription factors. The EIN3/EIL proteins were shown to regulate expression of the GCC-box-binding transcription factors, ethylene-response factors. It is known that the phenotype of the Arabidopsis thaliana EIN3 (AtEIN3)-deficient mutants, e.g. long seedlings in the presence of ethylene or its precursor, is suppressed by overexpression of Arabidopsis EIL1 (AtEIL1) or EIL2 (AtEIL2), indicating the functional equivalence of these proteins.

In the present study, a region corresponding to the major DBD of the EIN3/EIL transcription factor family, which is the key factor in the ethylene signaling, was identified. The isolated domain exists in a monomeric form and retained the sequence specificity for the DNA binding. The structure determined by NMR spectroscopy consists of five alpha-helices, packing into a novel fold dissimilar to known DBDs. An NMR titration analysis suggested that a region including the key mutation site, ein3-3 site, was shown to be involved in DNA binding.

Yamasaki K, Kigawa T, Inoue M, Yamasaki T, Yabuki T, Aoki M, Seki E, Matsuda T, Tomo Y, Terada T, Shirouzu M, Tanaka A, Seki M, Shinozaki K, Yokoyama S.
Solution structure of the major DNA-binding domain of Arabidopsis thaliana ethylene-insensitive3-like3.
J Mol Biol, 2005. 348(2): p. 253-64.
PMID: 15811366