PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Marchantia polymorpha
bHLH Family
Species TF ID Description
Mapoly0001s0259.1.pbHLH family protein
Mapoly0012s0026.1.pbHLH family protein
Mapoly0012s0202.1.pbHLH family protein
Mapoly0013s0167.1.pbHLH family protein
Mapoly0015s0001.1.pbHLH family protein
Mapoly0015s0003.1.pbHLH family protein
Mapoly0015s0003.2.pbHLH family protein
Mapoly0015s0003.3.pbHLH family protein
Mapoly0015s0003.4.pbHLH family protein
Mapoly0015s0003.5.pbHLH family protein
Mapoly0015s0003.6.pbHLH family protein
Mapoly0016s0110.1.pbHLH family protein
Mapoly0018s0018.1.pbHLH family protein
Mapoly0021s0100.1.pbHLH family protein
Mapoly0021s0101.1.pbHLH family protein
Mapoly0024s0106.1.pbHLH family protein
Mapoly0025s0044.1.pbHLH family protein
Mapoly0025s0044.2.pbHLH family protein
Mapoly0028s0058.1.pbHLH family protein
Mapoly0028s0060.1.pbHLH family protein
Mapoly0028s0062.1.pbHLH family protein
Mapoly0028s0062.2.pbHLH family protein
Mapoly0028s0100.1.pbHLH family protein
Mapoly0028s0101.1.pbHLH family protein
Mapoly0028s0101.2.pbHLH family protein
Mapoly0028s0101.3.pbHLH family protein
Mapoly0028s0101.4.pbHLH family protein
Mapoly0029s0130.1.pbHLH family protein
Mapoly0029s0130.2.pbHLH family protein
Mapoly0029s0135.1.pbHLH family protein
Mapoly0030s0141.1.pbHLH family protein
Mapoly0031s0072.1.pbHLH family protein
Mapoly0031s0074.1.pbHLH family protein
Mapoly0031s0075.1.pbHLH family protein
Mapoly0031s0076.1.pbHLH family protein
Mapoly0031s0161.1.pbHLH family protein
Mapoly0031s0161.2.pbHLH family protein
Mapoly0031s0161.3.pbHLH family protein
Mapoly0034s0053.1.pbHLH family protein
Mapoly0035s0146.1.pbHLH family protein
Mapoly0035s0146.2.pbHLH family protein
Mapoly0035s0146.3.pbHLH family protein
Mapoly0037s0007.1.pbHLH family protein
Mapoly0038s0058.1.pbHLH family protein
Mapoly0039s0003.1.pbHLH family protein
Mapoly0039s0059.10.pbHLH family protein
Mapoly0039s0059.11.pbHLH family protein
Mapoly0039s0059.12.pbHLH family protein
Mapoly0039s0059.13.pbHLH family protein
Mapoly0039s0059.1.pbHLH family protein
Mapoly0039s0059.2.pbHLH family protein
Mapoly0039s0059.3.pbHLH family protein
Mapoly0039s0059.4.pbHLH family protein
Mapoly0039s0059.5.pbHLH family protein
Mapoly0039s0059.6.pbHLH family protein
Mapoly0039s0059.7.pbHLH family protein
Mapoly0039s0059.8.pbHLH family protein
Mapoly0039s0059.9.pbHLH family protein
Mapoly0039s0068.1.pbHLH family protein
Mapoly0040s0112.1.pbHLH family protein
Mapoly0048s0099.1.pbHLH family protein
Mapoly0054s0021.1.pbHLH family protein
Mapoly0055s0052.1.pbHLH family protein
Mapoly0055s0052.2.pbHLH family protein
Mapoly0073s0051.1.pbHLH family protein
Mapoly0091s0008.1.pbHLH family protein
Mapoly0091s0008.2.pbHLH family protein
Mapoly0098s0046.1.pbHLH family protein
Mapoly0100s0033.1.pbHLH family protein
Mapoly0114s0037.1.pbHLH family protein
Mapoly0124s0021.1.pbHLH family protein
Mapoly0126s0029.1.pbHLH family protein
Mapoly0150s0015.1.pbHLH family protein
Mapoly0150s0016.1.pbHLH family protein
Mapoly0174s0004.1.pbHLH family protein
Mapoly0232s0001.1.pbHLH family protein
Mapoly0232s0001.2.pbHLH family protein
Mapoly0232s0001.3.pbHLH family protein
Mapoly0502s0001.1.pbHLH family protein
Mapoly0502s0001.2.pbHLH family protein
MapolyY_B0018.10.pbHLH family protein
MapolyY_B0018.11.pbHLH family protein
MapolyY_B0018.12.pbHLH family protein
MapolyY_B0018.13.pbHLH family protein
MapolyY_B0018.14.pbHLH family protein
MapolyY_B0018.15.pbHLH family protein
MapolyY_B0018.16.pbHLH family protein
MapolyY_B0018.17.pbHLH family protein
MapolyY_B0018.18.pbHLH family protein
MapolyY_B0018.19.pbHLH family protein
MapolyY_B0018.1.pbHLH family protein
MapolyY_B0018.20.pbHLH family protein
MapolyY_B0018.21.pbHLH family protein
MapolyY_B0018.22.pbHLH family protein
MapolyY_B0018.23.pbHLH family protein
MapolyY_B0018.24.pbHLH family protein
MapolyY_B0018.25.pbHLH family protein
MapolyY_B0018.2.pbHLH family protein
MapolyY_B0018.3.pbHLH family protein
MapolyY_B0018.4.pbHLH family protein
MapolyY_B0018.5.pbHLH family protein
MapolyY_B0018.6.pbHLH family protein
MapolyY_B0018.7.pbHLH family protein
MapolyY_B0018.8.pbHLH family protein
MapolyY_B0018.9.pbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250