PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Morus notabilis
bHLH Family
Species TF ID Description
XP_010087126.1bHLH family protein
XP_010087745.1bHLH family protein
XP_010087781.1bHLH family protein
XP_010088933.1bHLH family protein
XP_010089100.1bHLH family protein
XP_010089247.1bHLH family protein
XP_010090062.1bHLH family protein
XP_010090287.1bHLH family protein
XP_010090380.1bHLH family protein
XP_010090392.1bHLH family protein
XP_010090864.1bHLH family protein
XP_010091233.1bHLH family protein
XP_010091436.1bHLH family protein
XP_010091496.1bHLH family protein
XP_010091635.1bHLH family protein
XP_010091656.1bHLH family protein
XP_010091980.1bHLH family protein
XP_010092048.1bHLH family protein
XP_010092057.1bHLH family protein
XP_010092311.1bHLH family protein
XP_010092808.1bHLH family protein
XP_010093193.1bHLH family protein
XP_010093338.1bHLH family protein
XP_010093361.1bHLH family protein
XP_010093397.1bHLH family protein
XP_010093617.1bHLH family protein
XP_010093634.1bHLH family protein
XP_010093880.1bHLH family protein
XP_010093954.1bHLH family protein
XP_010094743.1bHLH family protein
XP_010094912.1bHLH family protein
XP_010095898.1bHLH family protein
XP_010096038.1bHLH family protein
XP_010096378.1bHLH family protein
XP_010096553.1bHLH family protein
XP_010096644.1bHLH family protein
XP_010097031.1bHLH family protein
XP_010097560.1bHLH family protein
XP_010097712.1bHLH family protein
XP_010097860.1bHLH family protein
XP_010098101.1bHLH family protein
XP_010098235.1bHLH family protein
XP_010098521.1bHLH family protein
XP_010098522.1bHLH family protein
XP_010098585.1bHLH family protein
XP_010098698.1bHLH family protein
XP_010098999.1bHLH family protein
XP_010099250.1bHLH family protein
XP_010099295.1bHLH family protein
XP_010099375.1bHLH family protein
XP_010100049.1bHLH family protein
XP_010100069.1bHLH family protein
XP_010100202.1bHLH family protein
XP_010100453.1bHLH family protein
XP_010100638.1bHLH family protein
XP_010100678.1bHLH family protein
XP_010100724.1bHLH family protein
XP_010100794.1bHLH family protein
XP_010101195.1bHLH family protein
XP_010101389.1bHLH family protein
XP_010101635.1bHLH family protein
XP_010102446.1bHLH family protein
XP_010102628.1bHLH family protein
XP_010103039.1bHLH family protein
XP_010103422.1bHLH family protein
XP_010104300.1bHLH family protein
XP_010104558.1bHLH family protein
XP_010105032.1bHLH family protein
XP_010105102.1bHLH family protein
XP_010105103.1bHLH family protein
XP_010105118.1bHLH family protein
XP_010105437.1bHLH family protein
XP_010105461.1bHLH family protein
XP_010106120.1bHLH family protein
XP_010106299.1bHLH family protein
XP_010106642.1bHLH family protein
XP_010106856.1bHLH family protein
XP_010107083.1bHLH family protein
XP_010107141.1bHLH family protein
XP_010107204.1bHLH family protein
XP_010107640.1bHLH family protein
XP_010107648.1bHLH family protein
XP_010107684.1bHLH family protein
XP_010107771.1bHLH family protein
XP_010107919.1bHLH family protein
XP_010108068.1bHLH family protein
XP_010108177.1bHLH family protein
XP_010108529.1bHLH family protein
XP_010108530.1bHLH family protein
XP_010108531.1bHLH family protein
XP_010108742.1bHLH family protein
XP_010108968.1bHLH family protein
XP_010109026.1bHLH family protein
XP_010109064.1bHLH family protein
XP_010109066.1bHLH family protein
XP_010109067.1bHLH family protein
XP_010109419.1bHLH family protein
XP_010109550.1bHLH family protein
XP_010109560.1bHLH family protein
XP_010109673.1bHLH family protein
XP_010110036.1bHLH family protein
XP_010111014.1bHLH family protein
XP_010111430.1bHLH family protein
XP_010111436.1bHLH family protein
XP_010111527.1bHLH family protein
XP_010111528.1bHLH family protein
XP_010111674.1bHLH family protein
XP_010111847.1bHLH family protein
XP_010111848.1bHLH family protein
XP_010111900.1bHLH family protein
XP_010112076.1bHLH family protein
XP_010112171.1bHLH family protein
XP_010112181.1bHLH family protein
XP_010112839.1bHLH family protein
XP_010113177.1bHLH family protein
XP_010113346.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250