PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Malus domestica
WOX Family
Species TF ID Description
MDP0000203666WOX family protein
MDP0000293200WOX family protein
MDP0000239235WOX family protein
MDP0000445859WOX family protein
MDP0000144307WOX family protein
MDP0000219162WOX family protein
MDP0000213910WOX family protein
MDP0000163159WOX family protein
MDP0000580356WOX family protein
MDP0000394158WOX family protein
MDP0000212434WOX family protein
MDP0000600720WOX family protein
MDP0000232004WOX family protein
MDP0000729328WOX family protein
MDP0000524885WOX family protein
MDP0000136426WOX family protein
MDP0000316517WOX family protein
MDP0000304650WOX family protein
MDP0000851699WOX family protein
MDP0000224466WOX family protein
MDP0000250248WOX family protein
MDP0000854437WOX family protein
MDP0000874562WOX family protein
WOX Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401


The WOX genes form a plant-specific subclade of the eukaryotic homeobox transcription factor superfamily, which is characterized by the presence of a conserved DNA-binding homeodomain. The analysis of WOX gene expression and function shows that WOX family members fulfill specialized functions in key developmental processes in plants, such as embryonic patterning, stem-cell maintenance and organ formation. These functions can be related to either promotion of cell division activity and/or prevention of premature cell differentiation.

van der Graaff E, Laux T, Rensing SA.
The WUS homeobox-containing (WOX) protein family.
Genome Biol, 2009. 10(12): p. 248.
PMID: 20067590