PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Malus domestica
HD-ZIP Family
Species TF ID Description
MDP0000427227HD-ZIP family protein
MDP0000737672HD-ZIP family protein
MDP0000150465HD-ZIP family protein
MDP0000138651HD-ZIP family protein
MDP0000229611HD-ZIP family protein
MDP0000423596HD-ZIP family protein
MDP0000564897HD-ZIP family protein
MDP0000598064HD-ZIP family protein
MDP0000152629HD-ZIP family protein
MDP0000737128HD-ZIP family protein
MDP0000124827HD-ZIP family protein
MDP0000145401HD-ZIP family protein
MDP0000624784HD-ZIP family protein
MDP0000599845HD-ZIP family protein
MDP0000859459HD-ZIP family protein
MDP0000509120HD-ZIP family protein
MDP0000608923HD-ZIP family protein
MDP0000281698HD-ZIP family protein
MDP0000736852HD-ZIP family protein
MDP0000273608HD-ZIP family protein
MDP0000135540HD-ZIP family protein
MDP0000222305HD-ZIP family protein
MDP0000206752HD-ZIP family protein
MDP0000163095HD-ZIP family protein
MDP0000270937HD-ZIP family protein
MDP0000423445HD-ZIP family protein
MDP0000607777HD-ZIP family protein
MDP0000150088HD-ZIP family protein
MDP0000193877HD-ZIP family protein
MDP0000579882HD-ZIP family protein
MDP0000899816HD-ZIP family protein
MDP0000316497HD-ZIP family protein
MDP0000172744HD-ZIP family protein
MDP0000119544HD-ZIP family protein
MDP0000142091HD-ZIP family protein
MDP0000230511HD-ZIP family protein
MDP0000131454HD-ZIP family protein
MDP0000670432HD-ZIP family protein
MDP0000134241HD-ZIP family protein
MDP0000730994HD-ZIP family protein
MDP0000180963HD-ZIP family protein
MDP0000738604HD-ZIP family protein
MDP0000615948HD-ZIP family protein
MDP0000311522HD-ZIP family protein
MDP0000789571HD-ZIP family protein
MDP0000188716HD-ZIP family protein
MDP0000909160HD-ZIP family protein
MDP0000146339HD-ZIP family protein
MDP0000206914HD-ZIP family protein
MDP0000866008HD-ZIP family protein
MDP0000238771HD-ZIP family protein
MDP0000913269HD-ZIP family protein
MDP0000142893HD-ZIP family protein
MDP0000318514HD-ZIP family protein
MDP0000389745HD-ZIP family protein
MDP0000046392HD-ZIP family protein
MDP0000233235HD-ZIP family protein
MDP0000763731HD-ZIP family protein
MDP0000285637HD-ZIP family protein
MDP0000491277HD-ZIP family protein
MDP0000204639HD-ZIP family protein
MDP0000765473HD-ZIP family protein
MDP0000005879HD-ZIP family protein
MDP0000840574HD-ZIP family protein
MDP0000126553HD-ZIP family protein
MDP0000943529HD-ZIP family protein
MDP0000050082HD-ZIP family protein
MDP0000251484HD-ZIP family protein
MDP0000313059HD-ZIP family protein
MDP0000123097HD-ZIP family protein
MDP0000426630HD-ZIP family protein
MDP0000322550HD-ZIP family protein
MDP0000236500HD-ZIP family protein
MDP0000242861HD-ZIP family protein
MDP0000125184HD-ZIP family protein
MDP0000125182HD-ZIP family protein
MDP0000149252HD-ZIP family protein
MDP0000222975HD-ZIP family protein
MDP0000411393HD-ZIP family protein
MDP0000224218HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401