PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Malus domestica
E2F/DP Family
Species TF ID Description
MDP0000124881E2F/DP family protein
MDP0000150153E2F/DP family protein
MDP0000150467E2F/DP family protein
MDP0000172879E2F/DP family protein
MDP0000187830E2F/DP family protein
MDP0000197904E2F/DP family protein
MDP0000200630E2F/DP family protein
MDP0000232265E2F/DP family protein
MDP0000248838E2F/DP family protein
MDP0000250386E2F/DP family protein
MDP0000258338E2F/DP family protein
MDP0000268258E2F/DP family protein
MDP0000311683E2F/DP family protein
MDP0000316055E2F/DP family protein
MDP0000734535E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710