PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Malus domestica
BES1 Family
Species TF ID Description
MDP0000127033BES1 family protein
MDP0000130173BES1 family protein
MDP0000146645BES1 family protein
MDP0000152511BES1 family protein
MDP0000157809BES1 family protein
MDP0000161508BES1 family protein
MDP0000190530BES1 family protein
MDP0000203462BES1 family protein
MDP0000206646BES1 family protein
MDP0000212411BES1 family protein
MDP0000218271BES1 family protein
MDP0000223799BES1 family protein
MDP0000232760BES1 family protein
MDP0000233714BES1 family protein
MDP0000262498BES1 family protein
MDP0000270344BES1 family protein
MDP0000276235BES1 family protein
MDP0000282531BES1 family protein
MDP0000289260BES1 family protein
MDP0000301320BES1 family protein
MDP0000306427BES1 family protein
MDP0000344348BES1 family protein
MDP0000410792BES1 family protein
MDP0000504505BES1 family protein
MDP0000529388BES1 family protein
MDP0000647877BES1 family protein
MDP0000742467BES1 family protein
MDP0000748952BES1 family protein
MDP0000908053BES1 family protein
BES1 Family Introduction

Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

Yin Y, Vafeados D, Tao Y, Yoshida S, Asami T, Chory J.
A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.
Cell. 2005 Jan 28;120(2):249-59.
PMID: 15680330