PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Malus domestica
AP2 Family
Species TF ID Description
MDP0000121984AP2 family protein
MDP0000122728AP2 family protein
MDP0000125317AP2 family protein
MDP0000133423AP2 family protein
MDP0000137561AP2 family protein
MDP0000142490AP2 family protein
MDP0000163645AP2 family protein
MDP0000166059AP2 family protein
MDP0000175309AP2 family protein
MDP0000181606AP2 family protein
MDP0000182395AP2 family protein
MDP0000186581AP2 family protein
MDP0000187703AP2 family protein
MDP0000190889AP2 family protein
MDP0000200319AP2 family protein
MDP0000206674AP2 family protein
MDP0000206676AP2 family protein
MDP0000211931AP2 family protein
MDP0000228713AP2 family protein
MDP0000231748AP2 family protein
MDP0000246608AP2 family protein
MDP0000277643AP2 family protein
MDP0000281784AP2 family protein
MDP0000287973AP2 family protein
MDP0000297196AP2 family protein
MDP0000297698AP2 family protein
MDP0000318457AP2 family protein
MDP0000801540AP2 family protein
MDP0000824178AP2 family protein
MDP0000871080AP2 family protein
MDP0000188698AP2 family protein
MDP0000201555AP2 family protein
MDP0000320993AP2 family protein
MDP0000286322AP2 family protein
MDP0000314518AP2 family protein
MDP0000803527AP2 family protein
MDP0000281079AP2 family protein
MDP0000285955AP2 family protein
MDP0000130802AP2 family protein
MDP0000296716AP2 family protein
MDP0000161347AP2 family protein
MDP0000204900AP2 family protein
MDP0000814798AP2 family protein
MDP0000248470AP2 family protein
MDP0000182455AP2 family protein
AP2 Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

Genes in the AP2 family have been shown to participate in the regulation of developmental processes, e.g. flower development, spikelet meristem determinacy, leaf epidermal cell identity, and embryo development.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444

Using an in vitro selection procedure, the DNA binding specificity of the two AP2 repeat containing protein ANT was found to be 5'-gCAC(A/G)N(A/T)TcCC(a/g)ANG(c/t)-3'. This consensus site is much longer than sites recognized by proteins containing a single AP2 repeat and neither AP2 repeat of ANT was alone capable of binding to the selected sequences, suggesting that both AP2 repeats make DNA contacts.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102