PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Linum usitatissimum
bHLH Family
Species TF ID Description
Lus10000037bHLH family protein
Lus10000208bHLH family protein
Lus10000332bHLH family protein
Lus10000484bHLH family protein
Lus10001066bHLH family protein
Lus10001068bHLH family protein
Lus10001271bHLH family protein
Lus10001885bHLH family protein
Lus10002160bHLH family protein
Lus10002213bHLH family protein
Lus10002337bHLH family protein
Lus10002390bHLH family protein
Lus10002720bHLH family protein
Lus10003172bHLH family protein
Lus10003386bHLH family protein
Lus10003471bHLH family protein
Lus10003488bHLH family protein
Lus10003500bHLH family protein
Lus10003823bHLH family protein
Lus10004315bHLH family protein
Lus10004574bHLH family protein
Lus10004575bHLH family protein
Lus10004630bHLH family protein
Lus10005091bHLH family protein
Lus10005451bHLH family protein
Lus10005710bHLH family protein
Lus10005959bHLH family protein
Lus10005966bHLH family protein
Lus10005999bHLH family protein
Lus10006085bHLH family protein
Lus10006491bHLH family protein
Lus10006587bHLH family protein
Lus10006951bHLH family protein
Lus10007049bHLH family protein
Lus10007101bHLH family protein
Lus10007139bHLH family protein
Lus10007502bHLH family protein
Lus10007613bHLH family protein
Lus10007618bHLH family protein
Lus10007974bHLH family protein
Lus10008626bHLH family protein
Lus10008804bHLH family protein
Lus10008896bHLH family protein
Lus10009034bHLH family protein
Lus10009261bHLH family protein
Lus10009475bHLH family protein
Lus10009673bHLH family protein
Lus10009726bHLH family protein
Lus10009745bHLH family protein
Lus10010101bHLH family protein
Lus10010453bHLH family protein
Lus10010503bHLH family protein
Lus10010638bHLH family protein
Lus10011167bHLH family protein
Lus10011172bHLH family protein
Lus10011307bHLH family protein
Lus10011578bHLH family protein
Lus10011899bHLH family protein
Lus10012457bHLH family protein
Lus10012484bHLH family protein
Lus10012603bHLH family protein
Lus10012670bHLH family protein
Lus10012737bHLH family protein
Lus10012842bHLH family protein
Lus10013052bHLH family protein
Lus10013284bHLH family protein
Lus10013502bHLH family protein
Lus10013874bHLH family protein
Lus10013917bHLH family protein
Lus10014279bHLH family protein
Lus10014300bHLH family protein
Lus10014726bHLH family protein
Lus10014807bHLH family protein
Lus10014938bHLH family protein
Lus10015704bHLH family protein
Lus10015734bHLH family protein
Lus10015902bHLH family protein
Lus10015909bHLH family protein
Lus10016151bHLH family protein
Lus10016680bHLH family protein
Lus10017152bHLH family protein
Lus10017602bHLH family protein
Lus10017634bHLH family protein
Lus10018020bHLH family protein
Lus10018395bHLH family protein
Lus10018400bHLH family protein
Lus10018723bHLH family protein
Lus10018724bHLH family protein
Lus10018761bHLH family protein
Lus10018787bHLH family protein
Lus10019247bHLH family protein
Lus10020069bHLH family protein
Lus10020478bHLH family protein
Lus10020503bHLH family protein
Lus10020727bHLH family protein
Lus10021023bHLH family protein
Lus10021199bHLH family protein
Lus10021416bHLH family protein
Lus10021711bHLH family protein
Lus10021846bHLH family protein
Lus10021876bHLH family protein
Lus10021968bHLH family protein
Lus10022032bHLH family protein
Lus10022186bHLH family protein
Lus10022218bHLH family protein
Lus10022833bHLH family protein
Lus10023428bHLH family protein
Lus10023562bHLH family protein
Lus10023610bHLH family protein
Lus10023669bHLH family protein
Lus10023829bHLH family protein
Lus10024071bHLH family protein
Lus10024233bHLH family protein
Lus10024241bHLH family protein
Lus10024631bHLH family protein
Lus10024811bHLH family protein
Lus10024812bHLH family protein
Lus10024850bHLH family protein
Lus10024871bHLH family protein
Lus10025518bHLH family protein
Lus10025599bHLH family protein
Lus10025987bHLH family protein
Lus10026008bHLH family protein
Lus10026278bHLH family protein
Lus10026589bHLH family protein
Lus10026684bHLH family protein
Lus10026733bHLH family protein
Lus10027064bHLH family protein
Lus10027300bHLH family protein
Lus10027394bHLH family protein
Lus10027395bHLH family protein
Lus10027396bHLH family protein
Lus10028175bHLH family protein
Lus10028456bHLH family protein
Lus10028978bHLH family protein
Lus10029110bHLH family protein
Lus10029460bHLH family protein
Lus10029805bHLH family protein
Lus10029950bHLH family protein
Lus10030243bHLH family protein
Lus10030490bHLH family protein
Lus10030581bHLH family protein
Lus10030609bHLH family protein
Lus10030807bHLH family protein
Lus10030880bHLH family protein
Lus10030908bHLH family protein
Lus10030970bHLH family protein
Lus10031255bHLH family protein
Lus10031675bHLH family protein
Lus10031676bHLH family protein
Lus10031677bHLH family protein
Lus10031826bHLH family protein
Lus10032267bHLH family protein
Lus10032542bHLH family protein
Lus10033120bHLH family protein
Lus10033488bHLH family protein
Lus10033562bHLH family protein
Lus10033592bHLH family protein
Lus10034031bHLH family protein
Lus10034271bHLH family protein
Lus10034358bHLH family protein
Lus10035056bHLH family protein
Lus10036068bHLH family protein
Lus10036286bHLH family protein
Lus10036659bHLH family protein
Lus10036732bHLH family protein
Lus10037198bHLH family protein
Lus10037484bHLH family protein
Lus10038020bHLH family protein
Lus10038306bHLH family protein
Lus10038432bHLH family protein
Lus10038550bHLH family protein
Lus10038823bHLH family protein
Lus10038939bHLH family protein
Lus10039006bHLH family protein
Lus10039328bHLH family protein
Lus10039631bHLH family protein
Lus10039639bHLH family protein
Lus10039640bHLH family protein
Lus10040448bHLH family protein
Lus10040506bHLH family protein
Lus10041148bHLH family protein
Lus10041261bHLH family protein
Lus10041493bHLH family protein
Lus10041592bHLH family protein
Lus10041649bHLH family protein
Lus10041908bHLH family protein
Lus10042017bHLH family protein
Lus10042128bHLH family protein
Lus10042349bHLH family protein
Lus10042395bHLH family protein
Lus10042572bHLH family protein
Lus10042647bHLH family protein
Lus10043076bHLH family protein
Lus10043199bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250