PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Linum usitatissimum
HD-ZIP Family
Species TF ID Description
Lus10037200HD-ZIP family protein
Lus10036730HD-ZIP family protein
Lus10042180HD-ZIP family protein
Lus10012845HD-ZIP family protein
Lus10030493HD-ZIP family protein
Lus10036674HD-ZIP family protein
Lus10040175HD-ZIP family protein
Lus10004377HD-ZIP family protein
Lus10022225HD-ZIP family protein
Lus10016254HD-ZIP family protein
Lus10029293HD-ZIP family protein
Lus10021064HD-ZIP family protein
Lus10033102HD-ZIP family protein
Lus10008795HD-ZIP family protein
Lus10004161HD-ZIP family protein
Lus10007849HD-ZIP family protein
Lus10004759HD-ZIP family protein
Lus10023159HD-ZIP family protein
Lus10036709HD-ZIP family protein
Lus10037218HD-ZIP family protein
Lus10013277HD-ZIP family protein
Lus10030214HD-ZIP family protein
Lus10030800HD-ZIP family protein
Lus10041719HD-ZIP family protein
Lus10004270HD-ZIP family protein
Lus10024031HD-ZIP family protein
Lus10032952HD-ZIP family protein
Lus10011935HD-ZIP family protein
Lus10008641HD-ZIP family protein
Lus10008840HD-ZIP family protein
Lus10011569HD-ZIP family protein
Lus10027633HD-ZIP family protein
Lus10019256HD-ZIP family protein
Lus10035583HD-ZIP family protein
Lus10013103HD-ZIP family protein
Lus10003492HD-ZIP family protein
Lus10005997HD-ZIP family protein
Lus10039644HD-ZIP family protein
Lus10007650HD-ZIP family protein
Lus10027175HD-ZIP family protein
Lus10039667HD-ZIP family protein
Lus10006765HD-ZIP family protein
Lus10020059HD-ZIP family protein
Lus10037554HD-ZIP family protein
Lus10011440HD-ZIP family protein
Lus10011426HD-ZIP family protein
Lus10011616HD-ZIP family protein
Lus10037568HD-ZIP family protein
Lus10031321HD-ZIP family protein
Lus10038449HD-ZIP family protein
Lus10036567HD-ZIP family protein
Lus10027437HD-ZIP family protein
Lus10023357HD-ZIP family protein
Lus10005759HD-ZIP family protein
Lus10041362HD-ZIP family protein
Lus10031892HD-ZIP family protein
Lus10000719HD-ZIP family protein
Lus10021470HD-ZIP family protein
Lus10005758HD-ZIP family protein
Lus10014997HD-ZIP family protein
Lus10025940HD-ZIP family protein
Lus10038877HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401