PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lactuca sativa
WRKY Family
Species TF ID Description
Lsa000484WRKY family protein
Lsa000924WRKY family protein
Lsa000994WRKY family protein
Lsa001256WRKY family protein
Lsa001489WRKY family protein
Lsa002516WRKY family protein
Lsa002907WRKY family protein
Lsa003004WRKY family protein
Lsa003006WRKY family protein
Lsa003338WRKY family protein
Lsa003345WRKY family protein
Lsa003672WRKY family protein
Lsa004000WRKY family protein
Lsa004323WRKY family protein
Lsa005482WRKY family protein
Lsa006127WRKY family protein
Lsa007403WRKY family protein
Lsa008231WRKY family protein
Lsa008493WRKY family protein
Lsa008582WRKY family protein
Lsa009015WRKY family protein
Lsa009402WRKY family protein
Lsa009950WRKY family protein
Lsa010327WRKY family protein
Lsa010352WRKY family protein
Lsa011203WRKY family protein
Lsa011965WRKY family protein
Lsa013490WRKY family protein
Lsa013574WRKY family protein
Lsa013859WRKY family protein
Lsa014522WRKY family protein
Lsa014931WRKY family protein
Lsa015920WRKY family protein
Lsa016297WRKY family protein
Lsa016614WRKY family protein
Lsa016626WRKY family protein
Lsa016951WRKY family protein
Lsa017125WRKY family protein
Lsa017402WRKY family protein
Lsa018230WRKY family protein
Lsa018325WRKY family protein
Lsa019310WRKY family protein
Lsa019486WRKY family protein
Lsa001881WRKY family protein
Lsa010316WRKY family protein
Lsa010913WRKY family protein
Lsa012509WRKY family protein
Lsa013141WRKY family protein
Lsa015699WRKY family protein
Lsa015893WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701