PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lactuca sativa
TCP Family
Species TF ID Description
Lsa000616TCP family protein
Lsa000779TCP family protein
Lsa001912TCP family protein
Lsa004945TCP family protein
Lsa006119TCP family protein
Lsa007426TCP family protein
Lsa007512TCP family protein
Lsa007740TCP family protein
Lsa009029TCP family protein
Lsa009151TCP family protein
Lsa011297TCP family protein
Lsa011966TCP family protein
Lsa017726TCP family protein
Lsa018363TCP family protein
Lsa019433TCP family protein
Lsa009777TCP family protein
Lsa014310TCP family protein
TCP Family Introduction

The TCP gene family was first described in 1999, as a small group of plant genes encoding proteins sharing the socalled TCP domain, a 59-amino acid basic helix-loop-helix (bHLH) motif that allows DNA binding and protein-protein interactions. This domain was initially identified in four proteins encoded by apparently unrelated genes, from which the name 'TCP' was derived: teosinte branched1 (tb1) from maize (Zea mays), CYCLOIDEA (CYC) from snapdragon (Antirrhinum majus), and the PROLIFERATING CELL FACTORS 1 and 2 (PCF1 and PCF2) from rice (Oryza sativa). The tb1 gene is a major determinant of strong apical dominance in domesticated maize. CYC is involved in the control of floral bilateral symmetry in Antirrhinum. PCF1 and PCF2 are factors that bind to the promoter of the rice PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) gene, which encodes a protein involved in DNA replication and repair, maintenance of chromatin structure, chromosome segregation and cell-cycle progression.

TCP genes have been found in various plant species, and new roles in plant development have been elucidated. These discoveries emphasize the importance of this plant-specific gene family in the evolution and developmental control of plant form.

Martin-Trillo M, Cubas P.
TCP genes: a family snapshot ten years later.
Trends Plant Sci, 2010. 15(1): p. 31-9.
PMID: 19963426