PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lactuca sativa
ERF Family
Species TF ID Description
Lsa000861ERF family protein
Lsa001554ERF family protein
Lsa001947ERF family protein
Lsa002231ERF family protein
Lsa002540ERF family protein
Lsa002648ERF family protein
Lsa003548ERF family protein
Lsa004254ERF family protein
Lsa004485ERF family protein
Lsa004953ERF family protein
Lsa005473ERF family protein
Lsa005488ERF family protein
Lsa005894ERF family protein
Lsa006968ERF family protein
Lsa007022ERF family protein
Lsa007289ERF family protein
Lsa008494ERF family protein
Lsa009109ERF family protein
Lsa009292ERF family protein
Lsa009583ERF family protein
Lsa009896ERF family protein
Lsa010128ERF family protein
Lsa010296ERF family protein
Lsa010402ERF family protein
Lsa010502ERF family protein
Lsa011148ERF family protein
Lsa011779ERF family protein
Lsa012080ERF family protein
Lsa012100ERF family protein
Lsa012776ERF family protein
Lsa013537ERF family protein
Lsa013696ERF family protein
Lsa013915ERF family protein
Lsa014230ERF family protein
Lsa014380ERF family protein
Lsa014713ERF family protein
Lsa014965ERF family protein
Lsa015126ERF family protein
Lsa015173ERF family protein
Lsa015294ERF family protein
Lsa015440ERF family protein
Lsa015602ERF family protein
Lsa015863ERF family protein
Lsa016051ERF family protein
Lsa016140ERF family protein
Lsa016647ERF family protein
Lsa016760ERF family protein
Lsa016955ERF family protein
Lsa017159ERF family protein
Lsa017431ERF family protein
Lsa017510ERF family protein
Lsa017779ERF family protein
Lsa017804ERF family protein
Lsa018083ERF family protein
Lsa018730ERF family protein
Lsa018766ERF family protein
Lsa019237ERF family protein
Lsa019613ERF family protein
Lsa002930ERF family protein
Lsa008196ERF family protein
Lsa013975ERF family protein
Lsa014383ERF family protein
Lsa015049ERF family protein
Lsa017180ERF family protein
Lsa017788ERF family protein
Lsa018342ERF family protein
ERF Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

After finding the tobacco ERFs, many proteins in the ERF family were identified and implicated in many diverse functions in cellular processes, such as hormonal signal transduction, response to biotic and abiotic stresses, regulation of metabolism, and in developmental processes in various plant species.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444


The first class are proteins which bind to ethylene response elements (ERE) or GCC boxes (tobacco EREBPs, Arabidopsis AtEBP and AtERF1-5, and tomato Pti4-6) found in the promoters of ethylene-inducible pathogenesis related genes. The GCC box is an 11 bp sequence (TAAGAGCCGCC) with a core GCCGCC sequence that is required for binding.
The second class includes proteins that bind to the C-repeat or dehydration response element (DRE) in the promoters of genes that are turned on in response to low temperatures and/or water deficit (CBF1, CBF2, CBF3/DREB1A and DREB2A). The C-repeat/DREs contain the core sequence CCGAC.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102