PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lactuca sativa
ARF Family
Species TF ID Description
Lsa002012ARF family protein
Lsa002056ARF family protein
Lsa003216ARF family protein
Lsa003707ARF family protein
Lsa004567ARF family protein
Lsa004622ARF family protein
Lsa004897ARF family protein
Lsa005365ARF family protein
Lsa006001ARF family protein
Lsa007568ARF family protein
Lsa009914ARF family protein
Lsa010658ARF family protein
Lsa015083ARF family protein
Lsa016595ARF family protein
Lsa016912ARF family protein
Lsa017902ARF family protein
Lsa018688ARF family protein
Lsa019285ARF family protein
Lsa016882ARF family protein
ARF Family Introduction

Auxin response factors (ARF) are transcription factors that regulate the expression of auxin response genes. ARFs bind with specificity to TGTCTC auxin response elements (AuxRE) in promoters of these genes and function in combination with Aux/IAA (auxin/indole acetic acid) repressors, which dimerize with ARF activators in an auxin-regulated manner.

Most ARFs consist of an amino-terminal DNA-binding domain (DBD), a middle region that functions as an activation domain (AD) or repression domain (RD), and a carboxy-terminal dimerization domain (CTD). The ARF DBD is classified as a plant-specific B3-type, but requires additional amino-terminal and carboxy-terminal amino acids for efficient in vitro binding to TGTCTC AuxREs.

The ARF ADs and RDs are located just carboxy-terminal to the DBDs and contain biased amino acid sequences. ARF ADs are enriched in glutamine along with serine and leucine residues, while ARF RDs are enriched in serine, proline, leucine and glycine residues.

Guilfoyle TJ, Hagen G.
Auxin response factors.
Curr Opin Plant Biol, 2007. 10(5): p. 453-60.
PMID: 17900969