PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Leersia perrieri
HD-ZIP Family
Species TF ID Description
LPERR08G15240.1HD-ZIP family protein
LPERR09G09790.1HD-ZIP family protein
LPERR03G05830.1HD-ZIP family protein
LPERR03G04660.1HD-ZIP family protein
LPERR04G16840.1HD-ZIP family protein
LPERR08G14440.1HD-ZIP family protein
LPERR08G12050.1HD-ZIP family protein
LPERR10G06660.1HD-ZIP family protein
LPERR09G08720.1HD-ZIP family protein
LPERR10G05640.1HD-ZIP family protein
LPERR04G16440.1HD-ZIP family protein
LPERR06G02280.1HD-ZIP family protein
LPERR03G08410.1HD-ZIP family protein
LPERR10G00150.1HD-ZIP family protein
LPERR02G21210.1HD-ZIP family protein
LPERR02G17070.1HD-ZIP family protein
LPERR06G02270.1HD-ZIP family protein
LPERR09G13180.1HD-ZIP family protein
LPERR01G20820.1HD-ZIP family protein
LPERR09G05860.1HD-ZIP family protein
LPERR07G17340.1HD-ZIP family protein
LPERR02G03410.1HD-ZIP family protein
LPERR03G06520.1HD-ZIP family protein
LPERR06G21680.1HD-ZIP family protein
LPERR01G36440.1HD-ZIP family protein
LPERR10G14410.1HD-ZIP family protein
LPERR01G03690.1HD-ZIP family protein
LPERR08G04930.1HD-ZIP family protein
LPERR08G04930.2HD-ZIP family protein
LPERR08G04930.3HD-ZIP family protein
LPERR08G04930.4HD-ZIP family protein
LPERR08G04930.5HD-ZIP family protein
LPERR08G04930.6HD-ZIP family protein
LPERR08G02370.1HD-ZIP family protein
LPERR04G21690.1HD-ZIP family protein
LPERR02G22520.1HD-ZIP family protein
LPERR01G27250.1HD-ZIP family protein
LPERR03G22530.1HD-ZIP family protein
LPERR01G06020.1HD-ZIP family protein
LPERR01G06020.2HD-ZIP family protein
LPERR09G13080.1HD-ZIP family protein
LPERR12G15670.1HD-ZIP family protein
LPERR04G18060.3HD-ZIP family protein
LPERR01G06020.3HD-ZIP family protein
LPERR03G00720.2HD-ZIP family protein
LPERR03G00720.1HD-ZIP family protein
LPERR10G09980.1HD-ZIP family protein
LPERR10G09980.2HD-ZIP family protein
LPERR04G18060.1HD-ZIP family protein
LPERR04G18060.2HD-ZIP family protein
LPERR10G15330.1HD-ZIP family protein
LPERR08G08160.1HD-ZIP family protein
LPERR01G29010.1HD-ZIP family protein
LPERR06G06240.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401