PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lotus japonicus
bHLH Family
Species TF ID Description
Lj0g3v0034169.1bHLH family protein
Lj0g3v0056309.1bHLH family protein
Lj0g3v0063509.1bHLH family protein
Lj0g3v0069559.1bHLH family protein
Lj0g3v0084249.1bHLH family protein
Lj0g3v0096699.1bHLH family protein
Lj0g3v0099719.1bHLH family protein
Lj0g3v0105629.1bHLH family protein
Lj0g3v0121629.1bHLH family protein
Lj0g3v0123959.1bHLH family protein
Lj0g3v0126899.1bHLH family protein
Lj0g3v0126899.2bHLH family protein
Lj0g3v0131909.1bHLH family protein
Lj0g3v0134409.1bHLH family protein
Lj0g3v0140069.1bHLH family protein
Lj0g3v0141839.1bHLH family protein
Lj0g3v0151119.1bHLH family protein
Lj0g3v0157999.1bHLH family protein
Lj0g3v0167589.1bHLH family protein
Lj0g3v0173869.1bHLH family protein
Lj0g3v0173869.2bHLH family protein
Lj0g3v0177679.1bHLH family protein
Lj0g3v0186939.1bHLH family protein
Lj0g3v0195439.1bHLH family protein
Lj0g3v0202299.1bHLH family protein
Lj0g3v0202329.1bHLH family protein
Lj0g3v0202379.1bHLH family protein
Lj0g3v0202379.2bHLH family protein
Lj0g3v0234069.1bHLH family protein
Lj0g3v0234069.2bHLH family protein
Lj0g3v0276629.1bHLH family protein
Lj0g3v0282189.1bHLH family protein
Lj0g3v0282449.1bHLH family protein
Lj0g3v0283229.1bHLH family protein
Lj0g3v0283609.1bHLH family protein
Lj0g3v0283609.2bHLH family protein
Lj0g3v0283609.3bHLH family protein
Lj0g3v0292969.1bHLH family protein
Lj0g3v0299319.1bHLH family protein
Lj0g3v0305759.1bHLH family protein
Lj0g3v0307149.1bHLH family protein
Lj0g3v0312929.1bHLH family protein
Lj0g3v0318189.1bHLH family protein
Lj0g3v0341529.1bHLH family protein
Lj0g3v0341529.2bHLH family protein
Lj0g3v0343449.1bHLH family protein
Lj0g3v0344429.2bHLH family protein
Lj0g3v0347479.1bHLH family protein
Lj0g3v0359189.2bHLH family protein
Lj1g3v0183020.1bHLH family protein
Lj1g3v0183020.2bHLH family protein
Lj1g3v0426840.1bHLH family protein
Lj1g3v0593350.1bHLH family protein
Lj1g3v0947460.1bHLH family protein
Lj1g3v0947460.2bHLH family protein
Lj1g3v1303700.1bHLH family protein
Lj1g3v1452960.1bHLH family protein
Lj1g3v1464130.1bHLH family protein
Lj1g3v1525930.1bHLH family protein
Lj1g3v1525930.2bHLH family protein
Lj1g3v1651330.1bHLH family protein
Lj1g3v2098310.1bHLH family protein
Lj1g3v2372350.1bHLH family protein
Lj1g3v2883900.1bHLH family protein
Lj1g3v3078240.1bHLH family protein
Lj1g3v3580670.1bHLH family protein
Lj1g3v3904220.1bHLH family protein
Lj1g3v4107000.1bHLH family protein
Lj1g3v4290130.2bHLH family protein
Lj1g3v4302180.1bHLH family protein
Lj1g3v4450440.1bHLH family protein
Lj1g3v4480290.1bHLH family protein
Lj1g3v4480290.2bHLH family protein
Lj1g3v4483600.1bHLH family protein
Lj1g3v4830130.1bHLH family protein
Lj1g3v4954920.1bHLH family protein
Lj2g3v0463790.1bHLH family protein
Lj2g3v0473830.1bHLH family protein
Lj2g3v0813500.1bHLH family protein
Lj2g3v1035930.1bHLH family protein
Lj2g3v1172460.1bHLH family protein
Lj2g3v1193050.1bHLH family protein
Lj2g3v1200030.1bHLH family protein
Lj2g3v1200030.2bHLH family protein
Lj2g3v1278950.1bHLH family protein
Lj2g3v1278950.2bHLH family protein
Lj2g3v1351570.1bHLH family protein
Lj2g3v1451710.1bHLH family protein
Lj2g3v1468080.1bHLH family protein
Lj2g3v1468080.2bHLH family protein
Lj2g3v1468080.3bHLH family protein
Lj2g3v1468530.1bHLH family protein
Lj2g3v1468540.1bHLH family protein
Lj2g3v1471910.1bHLH family protein
Lj2g3v1879750.1bHLH family protein
Lj2g3v1890910.1bHLH family protein
Lj2g3v1984450.1bHLH family protein
Lj2g3v1984550.1bHLH family protein
Lj2g3v1984550.2bHLH family protein
Lj2g3v1984620.1bHLH family protein
Lj2g3v2151670.1bHLH family protein
Lj2g3v2771140.1bHLH family protein
Lj3g3v0028570.1bHLH family protein
Lj3g3v0028580.1bHLH family protein
Lj3g3v0030630.1bHLH family protein
Lj3g3v0290430.1bHLH family protein
Lj3g3v0423730.1bHLH family protein
Lj3g3v0478050.1bHLH family protein
Lj3g3v0741510.1bHLH family protein
Lj3g3v0741510.2bHLH family protein
Lj3g3v0870610.1bHLH family protein
Lj3g3v1113460.1bHLH family protein
Lj3g3v1341620.1bHLH family protein
Lj3g3v1428150.1bHLH family protein
Lj3g3v1545570.1bHLH family protein
Lj3g3v1663540.1bHLH family protein
Lj3g3v1717780.1bHLH family protein
Lj3g3v1717780.2bHLH family protein
Lj3g3v1820800.3bHLH family protein
Lj3g3v2517670.1bHLH family protein
Lj3g3v2718820.1bHLH family protein
Lj3g3v2720020.1bHLH family protein
Lj3g3v2848980.1bHLH family protein
Lj3g3v3033250.2bHLH family protein
Lj3g3v3248370.1bHLH family protein
Lj3g3v3360870.1bHLH family protein
Lj3g3v3530640.1bHLH family protein
Lj3g3v3530640.2bHLH family protein
Lj3g3v3754390.1bHLH family protein
Lj3g3v3754390.2bHLH family protein
Lj4g3v0147800.1bHLH family protein
Lj4g3v0189910.1bHLH family protein
Lj4g3v0423240.1bHLH family protein
Lj4g3v0451060.1bHLH family protein
Lj4g3v0506920.1bHLH family protein
Lj4g3v0513460.2bHLH family protein
Lj4g3v0620080.1bHLH family protein
Lj4g3v0620100.1bHLH family protein
Lj4g3v0620150.1bHLH family protein
Lj4g3v0654660.1bHLH family protein
Lj4g3v1598230.1bHLH family protein
Lj4g3v2371640.1bHLH family protein
Lj4g3v2882120.1bHLH family protein
Lj4g3v2963430.1bHLH family protein
Lj4g3v3099330.1bHLH family protein
Lj5g3v0308790.1bHLH family protein
Lj5g3v0335560.1bHLH family protein
Lj5g3v1015130.1bHLH family protein
Lj5g3v1351980.1bHLH family protein
Lj5g3v1412970.2bHLH family protein
Lj5g3v1428970.1bHLH family protein
Lj5g3v1452280.1bHLH family protein
Lj5g3v1533330.1bHLH family protein
Lj5g3v1788210.1bHLH family protein
Lj5g3v1793440.1bHLH family protein
Lj5g3v1793440.2bHLH family protein
Lj5g3v2030790.1bHLH family protein
Lj5g3v2030790.2bHLH family protein
Lj5g3v2030810.1bHLH family protein
Lj5g3v2030810.2bHLH family protein
Lj5g3v2030840.1bHLH family protein
Lj5g3v2099550.1bHLH family protein
Lj5g3v2112180.1bHLH family protein
Lj5g3v2244610.1bHLH family protein
Lj6g3v0435130.1bHLH family protein
Lj6g3v0468630.1bHLH family protein
Lj6g3v0496230.1bHLH family protein
Lj6g3v0673230.1bHLH family protein
Lj6g3v1078430.1bHLH family protein
Lj6g3v1078430.2bHLH family protein
Lj6g3v1239580.1bHLH family protein
Lj6g3v1329780.1bHLH family protein
Lj6g3v1881430.1bHLH family protein
Lj6g3v2019730.1bHLH family protein
Lj6g3v2132220.1bHLH family protein
Lj6g3v2168640.1bHLH family protein
Lj6g3v2171830.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250