PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Lotus japonicus
HD-ZIP Family
Species TF ID Description
Lj2g3v1014380.1HD-ZIP family protein
Lj2g3v1327450.1HD-ZIP family protein
Lj2g3v1349130.1HD-ZIP family protein
Lj0g3v0168929.1HD-ZIP family protein
Lj4g3v1218330.1HD-ZIP family protein
Lj4g3v1218330.2HD-ZIP family protein
Lj4g3v1614670.1HD-ZIP family protein
Lj2g3v1034880.1HD-ZIP family protein
Lj0g3v0103139.1HD-ZIP family protein
Lj2g3v1989250.1HD-ZIP family protein
Lj3g3v0927080.1HD-ZIP family protein
Lj1g3v4350060.1HD-ZIP family protein
Lj3g3v0515110.1HD-ZIP family protein
Lj2g3v1316330.1HD-ZIP family protein
Lj6g3v1053520.2HD-ZIP family protein
Lj6g3v1053520.1HD-ZIP family protein
Lj2g3v1984020.1HD-ZIP family protein
Lj1g3v1037350.1HD-ZIP family protein
Lj0g3v0279669.1HD-ZIP family protein
Lj1g3v4693000.1HD-ZIP family protein
Lj1g3v4693000.2HD-ZIP family protein
Lj0g3v0072079.1HD-ZIP family protein
Lj0g3v0266959.1HD-ZIP family protein
Lj4g3v2140210.1HD-ZIP family protein
Lj1g3v1782140.1HD-ZIP family protein
Lj6g3v1300850.1HD-ZIP family protein
Lj3g3v0463690.1HD-ZIP family protein
Lj4g3v0633410.1HD-ZIP family protein
Lj3g3v0247270.1HD-ZIP family protein
Lj3g3v1338000.1HD-ZIP family protein
Lj3g3v1338000.2HD-ZIP family protein
Lj0g3v0262429.2HD-ZIP family protein
Lj0g3v0262429.3HD-ZIP family protein
Lj1g3v2611340.1HD-ZIP family protein
Lj0g3v0360389.2HD-ZIP family protein
Lj0g3v0360389.1HD-ZIP family protein
Lj1g3v0052560.1HD-ZIP family protein
Lj3g3v1541360.1HD-ZIP family protein
Lj5g3v2017090.1HD-ZIP family protein
Lj5g3v2017090.2HD-ZIP family protein
Lj6g3v1654310.1HD-ZIP family protein
Lj0g3v0251169.1HD-ZIP family protein
Lj3g3v1074990.2HD-ZIP family protein
Lj3g3v3085530.1HD-ZIP family protein
Lj4g3v2665270.1HD-ZIP family protein
Lj2g3v1509550.1HD-ZIP family protein
Lj0g3v0278949.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401