PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Kalanchoe laxiflora
bHLH Family
Species TF ID Description
Kaladp0001s0258.1.pbHLH family protein
Kaladp0001s0259.1.pbHLH family protein
Kaladp0005s0063.1.pbHLH family protein
Kaladp0006s0073.1.pbHLH family protein
Kaladp0006s0073.2.pbHLH family protein
Kaladp0006s0073.3.pbHLH family protein
Kaladp0006s0075.1.pbHLH family protein
Kaladp0006s0075.2.pbHLH family protein
Kaladp0006s0075.3.pbHLH family protein
Kaladp0007s0017.1.pbHLH family protein
Kaladp0008s0717.1.pbHLH family protein
Kaladp0008s0740.1.pbHLH family protein
Kaladp0009s0045.1.pbHLH family protein
Kaladp0010s0032.1.pbHLH family protein
Kaladp0010s0097.1.pbHLH family protein
Kaladp0010s0097.2.pbHLH family protein
Kaladp0011s0189.1.pbHLH family protein
Kaladp0011s0189.2.pbHLH family protein
Kaladp0011s0189.3.pbHLH family protein
Kaladp0011s0189.4.pbHLH family protein
Kaladp0011s0189.5.pbHLH family protein
Kaladp0011s0189.6.pbHLH family protein
Kaladp0012s0014.1.pbHLH family protein
Kaladp0012s0069.1.pbHLH family protein
Kaladp0012s0069.2.pbHLH family protein
Kaladp0012s0069.3.pbHLH family protein
Kaladp0012s0069.4.pbHLH family protein
Kaladp0015s0124.1.pbHLH family protein
Kaladp0015s0124.2.pbHLH family protein
Kaladp0015s0124.3.pbHLH family protein
Kaladp0016s0053.1.pbHLH family protein
Kaladp0016s0057.1.pbHLH family protein
Kaladp0016s0057.2.pbHLH family protein
Kaladp0016s0222.1.pbHLH family protein
Kaladp0016s0222.2.pbHLH family protein
Kaladp0016s0222.3.pbHLH family protein
Kaladp0016s0222.4.pbHLH family protein
Kaladp0016s0222.5.pbHLH family protein
Kaladp0016s0222.6.pbHLH family protein
Kaladp0016s0270.1.pbHLH family protein
Kaladp0016s0314.1.pbHLH family protein
Kaladp0016s0314.2.pbHLH family protein
Kaladp0016s0327.1.pbHLH family protein
Kaladp0018s0069.1.pbHLH family protein
Kaladp0019s0026.1.pbHLH family protein
Kaladp0019s0027.1.pbHLH family protein
Kaladp0019s0028.1.pbHLH family protein
Kaladp0019s0029.1.pbHLH family protein
Kaladp0019s0030.1.pbHLH family protein
Kaladp0019s0032.1.pbHLH family protein
Kaladp0019s0033.1.pbHLH family protein
Kaladp0019s0109.1.pbHLH family protein
Kaladp0020s0108.1.pbHLH family protein
Kaladp0020s0186.1.pbHLH family protein
Kaladp0020s0216.1.pbHLH family protein
Kaladp0020s0216.2.pbHLH family protein
Kaladp0020s0216.3.pbHLH family protein
Kaladp0021s0009.1.pbHLH family protein
Kaladp0021s0009.2.pbHLH family protein
Kaladp0022s0102.1.pbHLH family protein
Kaladp0022s0112.1.pbHLH family protein
Kaladp0023s0090.1.pbHLH family protein
Kaladp0024s0032.1.pbHLH family protein
Kaladp0024s0035.1.pbHLH family protein
Kaladp0024s0184.1.pbHLH family protein
Kaladp0024s0184.2.pbHLH family protein
Kaladp0024s0248.1.pbHLH family protein
Kaladp0024s0569.1.pbHLH family protein
Kaladp0024s0998.1.pbHLH family protein
Kaladp0028s0073.1.pbHLH family protein
Kaladp0030s0005.1.pbHLH family protein
Kaladp0031s0012.1.pbHLH family protein
Kaladp0031s0138.1.pbHLH family protein
Kaladp0033s0213.1.pbHLH family protein
Kaladp0033s0284.1.pbHLH family protein
Kaladp0034s0058.1.pbHLH family protein
Kaladp0034s0177.1.pbHLH family protein
Kaladp0035s0085.1.pbHLH family protein
Kaladp0035s0085.2.pbHLH family protein
Kaladp0035s0085.3.pbHLH family protein
Kaladp0035s0085.4.pbHLH family protein
Kaladp0035s0085.5.pbHLH family protein
Kaladp0035s0085.6.pbHLH family protein
Kaladp0035s0085.7.pbHLH family protein
Kaladp0036s0075.1.pbHLH family protein
Kaladp0036s0171.1.pbHLH family protein
Kaladp0036s0171.2.pbHLH family protein
Kaladp0037s0074.1.pbHLH family protein
Kaladp0037s0074.2.pbHLH family protein
Kaladp0037s0074.3.pbHLH family protein
Kaladp0037s0422.1.pbHLH family protein
Kaladp0039s0491.1.pbHLH family protein
Kaladp0039s0491.2.pbHLH family protein
Kaladp0040s0065.1.pbHLH family protein
Kaladp0040s0084.1.pbHLH family protein
Kaladp0040s0084.3.pbHLH family protein
Kaladp0040s0192.1.pbHLH family protein
Kaladp0040s0192.2.pbHLH family protein
Kaladp0040s0192.3.pbHLH family protein
Kaladp0040s0245.1.pbHLH family protein
Kaladp0040s0269.1.pbHLH family protein
Kaladp0040s0366.1.pbHLH family protein
Kaladp0040s0465.1.pbHLH family protein
Kaladp0040s0465.2.pbHLH family protein
Kaladp0040s0499.1.pbHLH family protein
Kaladp0040s0561.1.pbHLH family protein
Kaladp0042s0110.1.pbHLH family protein
Kaladp0042s0292.1.pbHLH family protein
Kaladp0042s0334.1.pbHLH family protein
Kaladp0043s0131.1.pbHLH family protein
Kaladp0043s0238.1.pbHLH family protein
Kaladp0044s0017.1.pbHLH family protein
Kaladp0044s0030.1.pbHLH family protein
Kaladp0045s0236.1.pbHLH family protein
Kaladp0045s0236.2.pbHLH family protein
Kaladp0045s0236.3.pbHLH family protein
Kaladp0045s0236.4.pbHLH family protein
Kaladp0045s0236.5.pbHLH family protein
Kaladp0045s0236.6.pbHLH family protein
Kaladp0046s0154.1.pbHLH family protein
Kaladp0048s0057.1.pbHLH family protein
Kaladp0048s0102.1.pbHLH family protein
Kaladp0048s0102.2.pbHLH family protein
Kaladp0048s0102.3.pbHLH family protein
Kaladp0048s0102.4.pbHLH family protein
Kaladp0048s0102.5.pbHLH family protein
Kaladp0048s0102.6.pbHLH family protein
Kaladp0048s0102.7.pbHLH family protein
Kaladp0048s0102.8.pbHLH family protein
Kaladp0048s0102.9.pbHLH family protein
Kaladp0048s0202.1.pbHLH family protein
Kaladp0048s0335.1.pbHLH family protein
Kaladp0048s0459.1.pbHLH family protein
Kaladp0048s0702.1.pbHLH family protein
Kaladp0048s0702.2.pbHLH family protein
Kaladp0048s0702.3.pbHLH family protein
Kaladp0048s0903.1.pbHLH family protein
Kaladp0048s0903.2.pbHLH family protein
Kaladp0049s0074.1.pbHLH family protein
Kaladp0050s0073.1.pbHLH family protein
Kaladp0050s0073.2.pbHLH family protein
Kaladp0050s0101.1.pbHLH family protein
Kaladp0050s0280.1.pbHLH family protein
Kaladp0053s0294.1.pbHLH family protein
Kaladp0053s0637.1.pbHLH family protein
Kaladp0053s0637.2.pbHLH family protein
Kaladp0053s0637.3.pbHLH family protein
Kaladp0053s0637.4.pbHLH family protein
Kaladp0055s0329.1.pbHLH family protein
Kaladp0057s0097.1.pbHLH family protein
Kaladp0058s0199.1.pbHLH family protein
Kaladp0058s0411.1.pbHLH family protein
Kaladp0059s0026.1.pbHLH family protein
Kaladp0059s0082.1.pbHLH family protein
Kaladp0060s0025.1.pbHLH family protein
Kaladp0060s0169.1.pbHLH family protein
Kaladp0060s0175.1.pbHLH family protein
Kaladp0060s0175.2.pbHLH family protein
Kaladp0060s0493.1.pbHLH family protein
Kaladp0061s0096.1.pbHLH family protein
Kaladp0061s0096.2.pbHLH family protein
Kaladp0061s0141.1.pbHLH family protein
Kaladp0063s0028.1.pbHLH family protein
Kaladp0064s0170.1.pbHLH family protein
Kaladp0066s0093.1.pbHLH family protein
Kaladp0066s0113.1.pbHLH family protein
Kaladp0066s0113.2.pbHLH family protein
Kaladp0066s0113.3.pbHLH family protein
Kaladp0066s0113.4.pbHLH family protein
Kaladp0067s0079.1.pbHLH family protein
Kaladp0067s0079.2.pbHLH family protein
Kaladp0067s0079.3.pbHLH family protein
Kaladp0067s0079.4.pbHLH family protein
Kaladp0068s0096.2.pbHLH family protein
Kaladp0068s0096.5.pbHLH family protein
Kaladp0068s0096.6.pbHLH family protein
Kaladp0068s0100.1.pbHLH family protein
Kaladp0069s0107.1.pbHLH family protein
Kaladp0071s0013.1.pbHLH family protein
Kaladp0071s0038.1.pbHLH family protein
Kaladp0071s0121.1.pbHLH family protein
Kaladp0071s0191.1.pbHLH family protein
Kaladp0071s0216.1.pbHLH family protein
Kaladp0071s0331.1.pbHLH family protein
Kaladp0071s0331.2.pbHLH family protein
Kaladp0071s0396.1.pbHLH family protein
Kaladp0071s0396.2.pbHLH family protein
Kaladp0076s0003.1.pbHLH family protein
Kaladp0081s0031.1.pbHLH family protein
Kaladp0081s0037.1.pbHLH family protein
Kaladp0081s0037.2.pbHLH family protein
Kaladp0081s0065.1.pbHLH family protein
Kaladp0081s0065.2.pbHLH family protein
Kaladp0081s0067.1.pbHLH family protein
Kaladp0081s0413.1.pbHLH family protein
Kaladp0082s0004.1.pbHLH family protein
Kaladp0082s0162.1.pbHLH family protein
Kaladp0089s0013.1.pbHLH family protein
Kaladp0089s0015.1.pbHLH family protein
Kaladp0089s0015.2.pbHLH family protein
Kaladp0089s0043.1.pbHLH family protein
Kaladp0089s0043.2.pbHLH family protein
Kaladp0089s0043.3.pbHLH family protein
Kaladp0090s0074.1.pbHLH family protein
Kaladp0091s0023.1.pbHLH family protein
Kaladp0091s0034.1.pbHLH family protein
Kaladp0093s0085.1.pbHLH family protein
Kaladp0093s0085.2.pbHLH family protein
Kaladp0093s0093.1.pbHLH family protein
Kaladp0095s0146.1.pbHLH family protein
Kaladp0095s0195.1.pbHLH family protein
Kaladp0095s0555.1.pbHLH family protein
Kaladp0095s0576.1.pbHLH family protein
Kaladp0095s0782.1.pbHLH family protein
Kaladp0096s0093.1.pbHLH family protein
Kaladp0099s0057.1.pbHLH family protein
Kaladp0100s0054.1.pbHLH family protein
Kaladp0101s0080.1.pbHLH family protein
Kaladp0101s0080.2.pbHLH family protein
Kaladp0101s0270.1.pbHLH family protein
Kaladp0110s0002.1.pbHLH family protein
Kaladp0210s0002.1.pbHLH family protein
Kaladp0210s0002.2.pbHLH family protein
Kaladp0210s0002.3.pbHLH family protein
Kaladp0210s0002.4.pbHLH family protein
Kaladp0210s0002.5.pbHLH family protein
Kaladp0337s0008.1.pbHLH family protein
Kaladp0337s0008.2.pbHLH family protein
Kaladp0337s0008.3.pbHLH family protein
Kaladp0476s0019.1.pbHLH family protein
Kaladp0476s0019.2.pbHLH family protein
Kaladp0476s0019.3.pbHLH family protein
Kaladp0476s0019.4.pbHLH family protein
Kaladp0476s0019.5.pbHLH family protein
Kaladp0489s0004.1.pbHLH family protein
Kaladp0550s0043.1.pbHLH family protein
Kaladp0607s0008.1.pbHLH family protein
Kaladp0671s0003.1.pbHLH family protein
Kaladp0671s0004.1.pbHLH family protein
Kaladp0674s0096.1.pbHLH family protein
Kaladp0674s0146.1.pbHLH family protein
Kaladp0747s0001.1.pbHLH family protein
Kaladp0807s0004.1.pbHLH family protein
Kaladp0807s0004.2.pbHLH family protein
Kaladp0995s0007.1.pbHLH family protein
Kaladp1222s0051.1.pbHLH family protein
Kaladp1282s0001.1.pbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250