PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Kalanchoe laxiflora
Species TF ID Description
Kaladp0003s0054.1.pMIKC_MADS family protein
Kaladp0008s0767.1.pMIKC_MADS family protein
Kaladp0016s0148.1.pMIKC_MADS family protein
Kaladp0016s0148.2.pMIKC_MADS family protein
Kaladp0017s0022.1.pMIKC_MADS family protein
Kaladp0018s0040.1.pMIKC_MADS family protein
Kaladp0018s0040.2.pMIKC_MADS family protein
Kaladp0018s0040.3.pMIKC_MADS family protein
Kaladp0018s0040.4.pMIKC_MADS family protein
Kaladp0018s0054.1.pMIKC_MADS family protein
Kaladp0018s0054.2.pMIKC_MADS family protein
Kaladp0019s0135.1.pMIKC_MADS family protein
Kaladp0019s0135.2.pMIKC_MADS family protein
Kaladp0019s0135.3.pMIKC_MADS family protein
Kaladp0020s0016.1.pMIKC_MADS family protein
Kaladp0020s0016.2.pMIKC_MADS family protein
Kaladp0022s0049.1.pMIKC_MADS family protein
Kaladp0024s0152.1.pMIKC_MADS family protein
Kaladp0024s0397.1.pMIKC_MADS family protein
Kaladp0024s0460.1.pMIKC_MADS family protein
Kaladp0026s0063.1.pMIKC_MADS family protein
Kaladp0026s0063.2.pMIKC_MADS family protein
Kaladp0026s0109.1.pMIKC_MADS family protein
Kaladp0036s0051.1.pMIKC_MADS family protein
Kaladp0036s0051.2.pMIKC_MADS family protein
Kaladp0036s0051.3.pMIKC_MADS family protein
Kaladp0036s0051.4.pMIKC_MADS family protein
Kaladp0036s0051.5.pMIKC_MADS family protein
Kaladp0040s0190.1.pMIKC_MADS family protein
Kaladp0040s0565.1.pMIKC_MADS family protein
Kaladp0045s0039.1.pMIKC_MADS family protein
Kaladp0048s0067.1.pMIKC_MADS family protein
Kaladp0048s0068.1.pMIKC_MADS family protein
Kaladp0050s0204.1.pMIKC_MADS family protein
Kaladp0050s0204.2.pMIKC_MADS family protein
Kaladp0053s0086.1.pMIKC_MADS family protein
Kaladp0055s0403.1.pMIKC_MADS family protein
Kaladp0055s0403.2.pMIKC_MADS family protein
Kaladp0060s0003.1.pMIKC_MADS family protein
Kaladp0061s0149.1.pMIKC_MADS family protein
Kaladp0062s0180.1.pMIKC_MADS family protein
Kaladp0062s0180.2.pMIKC_MADS family protein
Kaladp0062s0180.4.pMIKC_MADS family protein
Kaladp0062s0180.6.pMIKC_MADS family protein
Kaladp0065s0005.1.pMIKC_MADS family protein
Kaladp0065s0005.2.pMIKC_MADS family protein
Kaladp0067s0150.1.pMIKC_MADS family protein
Kaladp0067s0150.2.pMIKC_MADS family protein
Kaladp0067s0150.3.pMIKC_MADS family protein
Kaladp0067s0150.4.pMIKC_MADS family protein
Kaladp0067s0150.5.pMIKC_MADS family protein
Kaladp0067s0152.10.pMIKC_MADS family protein
Kaladp0067s0152.11.pMIKC_MADS family protein
Kaladp0067s0152.12.pMIKC_MADS family protein
Kaladp0067s0152.1.pMIKC_MADS family protein
Kaladp0067s0152.2.pMIKC_MADS family protein
Kaladp0067s0152.3.pMIKC_MADS family protein
Kaladp0067s0152.4.pMIKC_MADS family protein
Kaladp0067s0152.5.pMIKC_MADS family protein
Kaladp0067s0152.6.pMIKC_MADS family protein
Kaladp0067s0152.8.pMIKC_MADS family protein
Kaladp0067s0152.9.pMIKC_MADS family protein
Kaladp0079s0164.1.pMIKC_MADS family protein
Kaladp0080s0023.1.pMIKC_MADS family protein
Kaladp0080s0023.2.pMIKC_MADS family protein
Kaladp0080s0113.1.pMIKC_MADS family protein
Kaladp0080s0113.2.pMIKC_MADS family protein
Kaladp0080s0113.3.pMIKC_MADS family protein
Kaladp0080s0113.4.pMIKC_MADS family protein
Kaladp0080s0113.5.pMIKC_MADS family protein
Kaladp0080s0113.6.pMIKC_MADS family protein
Kaladp0080s0113.7.pMIKC_MADS family protein
Kaladp0082s0062.1.pMIKC_MADS family protein
Kaladp0082s0062.2.pMIKC_MADS family protein
Kaladp0088s0057.1.pMIKC_MADS family protein
Kaladp0093s0004.1.pMIKC_MADS family protein
Kaladp0093s0005.1.pMIKC_MADS family protein
Kaladp0093s0046.1.pMIKC_MADS family protein
Kaladp0093s0046.2.pMIKC_MADS family protein
Kaladp0093s0046.3.pMIKC_MADS family protein
Kaladp0094s0011.1.pMIKC_MADS family protein
Kaladp0095s0014.1.pMIKC_MADS family protein
Kaladp0095s0014.2.pMIKC_MADS family protein
Kaladp0095s0014.3.pMIKC_MADS family protein
Kaladp0095s0414.1.pMIKC_MADS family protein
Kaladp0095s0414.2.pMIKC_MADS family protein
Kaladp0095s0414.3.pMIKC_MADS family protein
Kaladp0100s0035.1.pMIKC_MADS family protein
Kaladp0100s0035.2.pMIKC_MADS family protein
Kaladp0674s0011.1.pMIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513